1J46A

3d solution nmr structure of the wild type hmg-box domain of the human male sex determining factor sry complexed to dna
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
85
structure length
85
Chain Sequence
MQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occurring point mutation.
pubmed doi rcsb
molecule tags Transcription/dna
source organism Homo sapiens
molecule keywords 5'-D(*CP*CP*TP*GP*CP*AP*CP*AP*AP*AP*CP*AP*CP*C)-3'
total genus 20
structure length 85
sequence length 85
ec nomenclature
pdb deposition date 2001-07-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00505 HMG_box HMG (high mobility group) box
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.30.10 Mainly Alpha Orthogonal Bundle DNA Binding (I), subunit A High mobility group box domain 1j46A00
1GT0D 1CKTA 2LY4A 1L8ZA 3NM9A 1AABA 2EQZA 2LEFA 1CG7A 1J3XA 1HMEA 2CO9A 1WZ6A 1HSMA 4EUWA 1K99A 1WGFA 1J47A 1HRZA 1V63A 3TMMA 1J3DA 2CS1A 1L8YA 1NHMA 2LHJA 4A3NA 2GZKA 1NHNA 4Y60C 1J5NA 1I11A 1J3CA 2RTUA 1HSNA 2YULA 2CRJA 2YUKA 1HRYA 2E6OA 4S2QD 1LWMA 1E7JA 1WXLA 2HDZA 3F27D 2D7LA 3TQ6A 1QRVA 2LE4A 1O4XB 1HMFA 4QR9A 2YQIA 2CTOA 1HMAA 1V64A 4NNUA 3U2BC 1J46A 4NODA 3FGHA 2YRQA
chains in the Genus database with same CATH superfamily
1GT0D 1CKTA 2LY4A 1L8ZA 3NM9A 1AABA 2EQZA 2LEFA 1CG7A 1J3XA 1HMEA 2CO9A 1WZ6A 1HSMA 4EUWA 1K99A 1WGFA 1J47A 1HRZA 1V63A 3TMMA 1J3DA 2CS1A 1L8YA 1NHMA 2LHJA 4A3NA 2GZKA 1NHNA 4Y60C 2VSFA 1J5NA 1I11A 1J3CA 2RTUA 1HSNA 2YULA 2CRJA 4A15A 2YUKA 3ABRB 1HRYA 2E6OA 4KQEA 1LWMA 4S2QD 1E7JA 1WXLA 2HDZA 3F27D 2D7LA 3TQ6A 1QRVA 2LE4A 3ABOB 1O4XB 1HMFA 4QR9A 2YQIA 2CTOA 3AO0B 5H8WA 1HMAA 1V64A 4NNUA 3U2BC 1J46A 3ANYB 4NODA 3ABSB 3FGHA 2YRQA
chains in the Genus database with same CATH topology
1GT0D 1CKTA 2LY4A 1L8ZA 3NM9A 1AABA 2EQZA 2LEFA 1CG7A 1J3XA 1HMEA 2CO9A 1WZ6A 1HSMA 4EUWA 1K99A 1WGFA 1J47A 1HRZA 1V63A 3TMMA 1J3DA 2CS1A 1L8YA 1NHMA 2LHJA 4A3NA 2GZKA 1NHNA 4Y60C 1J5NA 1I11A 1J3CA 2RTUA 1HSNA 2YULA 2CRJA 2YUKA 1HRYA 2E6OA 4S2QD 1LWMA 1E7JA 1WXLA 2HDZA 3F27D 2D7LA 3TQ6A 1QRVA 2LE4A 1O4XB 1HMFA 4QR9A 2YQIA 2CTOA 1HMAA 1V64A 4NNUA 3U2BC 1J46A 4NODA 3FGHA 2YRQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GT0 D;  1CKT A;  2LY4 A;  1L8Z A;  3NM9 A;  1AAB A;  2EQZ A;  2LEF A;  1CG7 A;  1J3X A;  1HME A;  2CO9 A;  1WZ6 A;  1HSM A;  4EUW A;  1K99 A;  1WGF A;  1J47 A;  1HRZ A;  1V63 A;  3TMM A;  1J3D A;  2CS1 A;  1L8Y A;  1NHM A;  2LHJ A;  4A3N A;  2GZK A;  1NHN A;  4Y60 C;  1J5N A;  1I11 A;  1J3C A;  2RTU A;  1HSN A;  2YUL A;  2CRJ A;  2YUK A;  1HRY A;  2E6O A;  4S2Q D;  1LWM A;  1E7J A;  1WXL A;  2HDZ A;  3F27 D;  2D7L A;  3TQ6 A;  1QRV A;  2LE4 A;  1O4X B;  1HMF A;  4QR9 A;  2YQI A;  2CTO A;  1HMA A;  1V64 A;  4NNU A;  3U2B C;  1J46 A;  4NOD A;  3FGH A;  2YRQ A; 
#chains in the Genus database with same CATH topology
 1GT0 D;  1CKT A;  2LY4 A;  1L8Z A;  3NM9 A;  1AAB A;  2EQZ A;  2LEF A;  1CG7 A;  1J3X A;  1HME A;  2CO9 A;  1WZ6 A;  1HSM A;  4EUW A;  1K99 A;  1WGF A;  1J47 A;  1HRZ A;  1V63 A;  3TMM A;  1J3D A;  2CS1 A;  1L8Y A;  1NHM A;  2LHJ A;  4A3N A;  2GZK A;  1NHN A;  4Y60 C;  2VSF A;  1J5N A;  1I11 A;  1J3C A;  2RTU A;  1HSN A;  2YUL A;  2CRJ A;  4A15 A;  2YUK A;  3ABR B;  1HRY A;  2E6O A;  4KQE A;  1LWM A;  4S2Q D;  1E7J A;  1WXL A;  2HDZ A;  3F27 D;  2D7L A;  3TQ6 A;  1QRV A;  2LE4 A;  3ABO B;  1O4X B;  1HMF A;  4QR9 A;  2YQI A;  2CTO A;  3AO0 B;  5H8W A;  1HMA A;  1V64 A;  4NNU A;  3U2B C;  1J46 A;  3ANY B;  4NOD A;  3ABS B;  3FGH A;  2YRQ A; 
#chains in the Genus database with same CATH homology
 1GT0 D;  1CKT A;  2LY4 A;  1L8Z A;  3NM9 A;  1AAB A;  2EQZ A;  2LEF A;  1CG7 A;  1J3X A;  1HME A;  2CO9 A;  1WZ6 A;  1HSM A;  4EUW A;  1K99 A;  1WGF A;  1J47 A;  1HRZ A;  1V63 A;  3TMM A;  1J3D A;  2CS1 A;  1L8Y A;  1NHM A;  2LHJ A;  4A3N A;  2GZK A;  1NHN A;  4Y60 C;  1J5N A;  1I11 A;  1J3C A;  2RTU A;  1HSN A;  2YUL A;  2CRJ A;  2YUK A;  1HRY A;  2E6O A;  4S2Q D;  1LWM A;  1E7J A;  1WXL A;  2HDZ A;  3F27 D;  2D7L A;  3TQ6 A;  1QRV A;  2LE4 A;  1O4X B;  1HMF A;  4QR9 A;  2YQI A;  2CTO A;  1HMA A;  1V64 A;  4NNU A;  3U2B C;  1J46 A;  4NOD A;  3FGH A;  2YRQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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