1KPKA

Crystal structure of the clc chloride channel from e. coli
Total Genus 150
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
150
sequence length
450
structure length
450
Chain Sequence
QAARLRRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.
pubmed doi rcsb
molecule tags Membrane protein
source organism Escherichia coli
molecule keywords putative channel transporter
total genus 150
structure length 450
sequence length 450
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 2001-12-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 1kpkA00
2FEEA 1OTTA 4KKAA 4KKBA 2FECA 4FTPA 2HLFA 2H2PA 4KK6A 1KPLA 4KKCA 2HT2A 3EJYA 2EXYA 2HT3A 4KJQA 2FEDA 3EJZA 4KK9A 4ENEA 2HTLA 3DETA 3Q17A 1OTUA 4KJPA 4FG6A 2EXWA 1OTSA 4KK5A 2EZ0A 3ND0A 2R9HA 4KKLA 2H2SA 3ORGA 4KK8A 1KPKA 4LOUA 4MQXA 4KJWA 3NMOA 2HTKA 2HT4A 5HD8A
chains in the Genus database with same CATH superfamily
2FEEA 1OTTA 4KKAA 4KKBA 2FECA 4FTPA 2HLFA 2H2PA 4KK6A 1KPLA 4KKCA 2HT2A 3EJYA 2EXYA 2HT3A 4KJQA 2FEDA 3EJZA 4KK9A 4ENEA 2HTLA 3DETA 3Q17A 1OTUA 4KJPA 4FG6A 2EXWA 1OTSA 4KK5A 2EZ0A 3ND0A 2R9HA 4KKLA 2H2SA 3ORGA 4KK8A 1KPKA 4LOUA 4MQXA 4KJWA 3NMOA 2HTKA 2HT4A 5HD8A
chains in the Genus database with same CATH topology
2FEEA 1OTTA 4KKAA 4KKBA 2FECA 4FTPA 2HLFA 2H2PA 4KK6A 1KPLA 4KKCA 2HT2A 3EJYA 2EXYA 2HT3A 4KJQA 2FEDA 3EJZA 4KK9A 4ENEA 2HTLA 3DETA 3Q17A 1OTUA 4KJPA 4FG6A 2EXWA 1OTSA 4KK5A 2EZ0A 3ND0A 2R9HA 4KKLA 2H2SA 3ORGA 4KK8A 1KPKA 4LOUA 4MQXA 4KJWA 3NMOA 2HTKA 2HT4A 5HD8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FEE A;  1OTT A;  4KKA A;  4KKB A;  2FEC A;  4FTP A;  2HLF A;  2H2P A;  4KK6 A;  1KPL A;  4KKC A;  2HT2 A;  3EJY A;  2EXY A;  2HT3 A;  4KJQ A;  2FED A;  3EJZ A;  4KK9 A;  4ENE A;  2HTL A;  3DET A;  3Q17 A;  1OTU A;  4KJP A;  4FG6 A;  2EXW A;  1OTS A;  4KK5 A;  2EZ0 A;  3ND0 A;  2R9H A;  4KKL A;  2H2S A;  3ORG A;  4KK8 A;  1KPK A;  4LOU A;  4MQX A;  4KJW A;  3NMO A;  2HTK A;  2HT4 A;  5HD8 A; 
#chains in the Genus database with same CATH topology
 2FEE A;  1OTT A;  4KKA A;  4KKB A;  2FEC A;  4FTP A;  2HLF A;  2H2P A;  4KK6 A;  1KPL A;  4KKC A;  2HT2 A;  3EJY A;  2EXY A;  2HT3 A;  4KJQ A;  2FED A;  3EJZ A;  4KK9 A;  4ENE A;  2HTL A;  3DET A;  3Q17 A;  1OTU A;  4KJP A;  4FG6 A;  2EXW A;  1OTS A;  4KK5 A;  2EZ0 A;  3ND0 A;  2R9H A;  4KKL A;  2H2S A;  3ORG A;  4KK8 A;  1KPK A;  4LOU A;  4MQX A;  4KJW A;  3NMO A;  2HTK A;  2HT4 A;  5HD8 A; 
#chains in the Genus database with same CATH homology
 2FEE A;  1OTT A;  4KKA A;  4KKB A;  2FEC A;  4FTP A;  2HLF A;  2H2P A;  4KK6 A;  1KPL A;  4KKC A;  2HT2 A;  3EJY A;  2EXY A;  2HT3 A;  4KJQ A;  2FED A;  3EJZ A;  4KK9 A;  4ENE A;  2HTL A;  3DET A;  3Q17 A;  1OTU A;  4KJP A;  4FG6 A;  2EXW A;  1OTS A;  4KK5 A;  2EZ0 A;  3ND0 A;  2R9H A;  4KKL A;  2H2S A;  3ORG A;  4KK8 A;  1KPK A;  4LOU A;  4MQX A;  4KJW A;  3NMO A;  2HTK A;  2HT4 A;  5HD8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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