2HT4A

Structure of the escherichia coli clc chloride channel y445w mutant and fab complex
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLWSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Membrane protein
molecule keywords H(+)/Cl(-) exchange transporter clcA
publication title Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger.
pubmed doi rcsb
source organism Escherichia coli
total genus 177
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2ht4A00
1KPLA 4KK6A 3ND0A 4KK8A 4ENEA 2EXWA 2HT2A 1OTTA 2H2SA 3ORGA 2H2PA 5HD8A 1KPKA 2R9HA 4LOUA 2EZ0A 4FG6A 4FTPA 4KKBA 2HLFA 1OTUA 2EXYA 2FECA 3Q17A 2FEDA 4MQXA 2HT4A 3NMOA 3EJZA 3DETA 4KJPA 4KKAA 2HTLA 4KK9A 1OTSA 4KK5A 4KJQA 4KKCA 2HT3A 2HTKA 4KJWA 3EJYA 2FEEA 4KKLA
chains in the Genus database with same CATH superfamily
1KPLA 4KK6A 3ND0A 4KK8A 4ENEA 2EXWA 2HT2A 1OTTA 2H2SA 3ORGA 2H2PA 5HD8A 1KPKA 2R9HA 4LOUA 2EZ0A 4FG6A 4FTPA 4KKBA 2HLFA 1OTUA 2EXYA 2FECA 3Q17A 2FEDA 4MQXA 2HT4A 3NMOA 3EJZA 3DETA 4KJPA 4KKAA 2HTLA 4KK9A 1OTSA 4KK5A 4KJQA 4KKCA 2HT3A 2HTKA 4KJWA 3EJYA 2FEEA 4KKLA
chains in the Genus database with same CATH topology
1KPLA 4KK6A 3ND0A 4KK8A 4ENEA 2EXWA 2HT2A 1OTTA 2H2SA 3ORGA 2H2PA 5HD8A 1KPKA 2R9HA 4LOUA 2EZ0A 4FG6A 4FTPA 4KKBA 2HLFA 1OTUA 2EXYA 2FECA 3Q17A 2FEDA 4MQXA 2HT4A 3NMOA 3EJZA 3DETA 4KJPA 4KKAA 2HTLA 4KK9A 1OTSA 4KK5A 4KJQA 4KKCA 2HT3A 2HTKA 4KJWA 3EJYA 2FEEA 4KKLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KPL A;  4KK6 A;  3ND0 A;  4KK8 A;  4ENE A;  2EXW A;  2HT2 A;  1OTT A;  2H2S A;  3ORG A;  2H2P A;  5HD8 A;  1KPK A;  2R9H A;  4LOU A;  2EZ0 A;  4FG6 A;  4FTP A;  4KKB A;  2HLF A;  1OTU A;  2EXY A;  2FEC A;  3Q17 A;  2FED A;  4MQX A;  2HT4 A;  3NMO A;  3EJZ A;  3DET A;  4KJP A;  4KKA A;  2HTL A;  4KK9 A;  1OTS A;  4KK5 A;  4KJQ A;  4KKC A;  2HT3 A;  2HTK A;  4KJW A;  3EJY A;  2FEE A;  4KKL A; 
#chains in the Genus database with same CATH topology
 1KPL A;  4KK6 A;  3ND0 A;  4KK8 A;  4ENE A;  2EXW A;  2HT2 A;  1OTT A;  2H2S A;  3ORG A;  2H2P A;  5HD8 A;  1KPK A;  2R9H A;  4LOU A;  2EZ0 A;  4FG6 A;  4FTP A;  4KKB A;  2HLF A;  1OTU A;  2EXY A;  2FEC A;  3Q17 A;  2FED A;  4MQX A;  2HT4 A;  3NMO A;  3EJZ A;  3DET A;  4KJP A;  4KKA A;  2HTL A;  4KK9 A;  1OTS A;  4KK5 A;  4KJQ A;  4KKC A;  2HT3 A;  2HTK A;  4KJW A;  3EJY A;  2FEE A;  4KKL A; 
#chains in the Genus database with same CATH homology
 1KPL A;  4KK6 A;  3ND0 A;  4KK8 A;  4ENE A;  2EXW A;  2HT2 A;  1OTT A;  2H2S A;  3ORG A;  2H2P A;  5HD8 A;  1KPK A;  2R9H A;  4LOU A;  2EZ0 A;  4FG6 A;  4FTP A;  4KKB A;  2HLF A;  1OTU A;  2EXY A;  2FEC A;  3Q17 A;  2FED A;  4MQX A;  2HT4 A;  3NMO A;  3EJZ A;  3DET A;  4KJP A;  4KKA A;  2HTL A;  4KK9 A;  1OTS A;  4KK5 A;  4KJQ A;  4KKC A;  2HT3 A;  2HTK A;  4KJW A;  3EJY A;  2FEE A;  4KKL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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