2EXYA

Crystal structure of the e148q mutant of ecclc, fab complexed in absence of bound ions
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRQGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Membrane protein
molecule keywords H(+)/Cl(-) exchange transporter clcA
publication title Ion-binding properties of the ClC chloride selectivity filter.
pubmed doi rcsb
source organism Escherichia coli
total genus 157
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2exyA00
4KJQA 4KKCA 2EXYA 2H2PA 2HT4A 4KKAA 2FECA 3Q17A 1OTSA 2HLFA 4KJPA 4KKBA 4LOUA 2HT2A 3ORGA 3NMOA 1KPKA 1OTTA 3EJYA 4FTPA 1OTUA 4MQXA 2EXWA 2HTKA 2FEEA 2HTLA 2H2SA 4KK5A 3EJZA 4ENEA 5HD8A 4KJWA 4KK6A 2FEDA 2EZ0A 4KKLA 4KK9A 2HT3A 4FG6A 4KK8A 3ND0A 1KPLA 2R9HA 3DETA
chains in the Genus database with same CATH superfamily
4KJQA 4KKCA 2EXYA 2H2PA 2HT4A 4KKAA 2FECA 3Q17A 1OTSA 2HLFA 4KJPA 4KKBA 4LOUA 2HT2A 3ORGA 3NMOA 1KPKA 1OTTA 3EJYA 4FTPA 1OTUA 4MQXA 2EXWA 2HTKA 2FEEA 2HTLA 2H2SA 4KK5A 3EJZA 4ENEA 5HD8A 4KJWA 4KK6A 2FEDA 2EZ0A 4KKLA 4KK9A 2HT3A 4FG6A 4KK8A 3ND0A 1KPLA 2R9HA 3DETA
chains in the Genus database with same CATH topology
4KJQA 4KKCA 2EXYA 2H2PA 2HT4A 4KKAA 2FECA 3Q17A 1OTSA 2HLFA 4KJPA 4KKBA 4LOUA 2HT2A 3ORGA 3NMOA 1KPKA 1OTTA 3EJYA 4FTPA 1OTUA 4MQXA 2EXWA 2HTKA 2FEEA 2HTLA 2H2SA 4KK5A 3EJZA 4ENEA 5HD8A 4KJWA 4KK6A 2FEDA 2EZ0A 4KKLA 4KK9A 2HT3A 4FG6A 4KK8A 3ND0A 1KPLA 2R9HA 3DETA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KJQ A;  4KKC A;  2EXY A;  2H2P A;  2HT4 A;  4KKA A;  2FEC A;  3Q17 A;  1OTS A;  2HLF A;  4KJP A;  4KKB A;  4LOU A;  2HT2 A;  3ORG A;  3NMO A;  1KPK A;  1OTT A;  3EJY A;  4FTP A;  1OTU A;  4MQX A;  2EXW A;  2HTK A;  2FEE A;  2HTL A;  2H2S A;  4KK5 A;  3EJZ A;  4ENE A;  5HD8 A;  4KJW A;  4KK6 A;  2FED A;  2EZ0 A;  4KKL A;  4KK9 A;  2HT3 A;  4FG6 A;  4KK8 A;  3ND0 A;  1KPL A;  2R9H A;  3DET A; 
#chains in the Genus database with same CATH topology
 4KJQ A;  4KKC A;  2EXY A;  2H2P A;  2HT4 A;  4KKA A;  2FEC A;  3Q17 A;  1OTS A;  2HLF A;  4KJP A;  4KKB A;  4LOU A;  2HT2 A;  3ORG A;  3NMO A;  1KPK A;  1OTT A;  3EJY A;  4FTP A;  1OTU A;  4MQX A;  2EXW A;  2HTK A;  2FEE A;  2HTL A;  2H2S A;  4KK5 A;  3EJZ A;  4ENE A;  5HD8 A;  4KJW A;  4KK6 A;  2FED A;  2EZ0 A;  4KKL A;  4KK9 A;  2HT3 A;  4FG6 A;  4KK8 A;  3ND0 A;  1KPL A;  2R9H A;  3DET A; 
#chains in the Genus database with same CATH homology
 4KJQ A;  4KKC A;  2EXY A;  2H2P A;  2HT4 A;  4KKA A;  2FEC A;  3Q17 A;  1OTS A;  2HLF A;  4KJP A;  4KKB A;  4LOU A;  2HT2 A;  3ORG A;  3NMO A;  1KPK A;  1OTT A;  3EJY A;  4FTP A;  1OTU A;  4MQX A;  2EXW A;  2HTK A;  2FEE A;  2HTL A;  2H2S A;  4KK5 A;  3EJZ A;  4ENE A;  5HD8 A;  4KJW A;  4KK6 A;  2FED A;  2EZ0 A;  4KKL A;  4KK9 A;  2HT3 A;  4FG6 A;  4KK8 A;  3ND0 A;  1KPL A;  2R9H A;  3DET A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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