4KKCA

Structure of the e148a mutant of clc-ec1 deltanc construct in 20mm bromide
Total Genus 165
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRAGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transport protein
molecule keywords H(+)/Cl(-) exchange transporter ClcA
publication title Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
pubmed doi rcsb
source organism Escherichia coli
total genus 165
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 4kkcA00
2HTLA 4KK6A 3NMOA 1KPLA 2HT3A 4FG6A 2H2SA 4LOUA 3EJZA 4KKCA 2HLFA 4KKLA 1KPKA 3ORGA 2FECA 2HT4A 4KJWA 4KKAA 3ND0A 3EJYA 3DETA 1OTUA 4ENEA 4KKBA 4MQXA 5HD8A 4KK8A 2EXYA 4KK9A 3Q17A 2EZ0A 2H2PA 2HTKA 2EXWA 2FEDA 1OTTA 2HT2A 4KJPA 4KJQA 1OTSA 2FEEA 2R9HA 4FTPA 4KK5A
chains in the Genus database with same CATH superfamily
2HTLA 4KK6A 3NMOA 1KPLA 2HT3A 4FG6A 2H2SA 4LOUA 3EJZA 4KKCA 2HLFA 4KKLA 1KPKA 3ORGA 2FECA 2HT4A 4KJWA 4KKAA 3ND0A 3EJYA 3DETA 1OTUA 4ENEA 4KKBA 4MQXA 5HD8A 4KK8A 2EXYA 4KK9A 3Q17A 2EZ0A 2H2PA 2HTKA 2EXWA 2FEDA 1OTTA 2HT2A 4KJPA 4KJQA 1OTSA 2FEEA 2R9HA 4FTPA 4KK5A
chains in the Genus database with same CATH topology
2HTLA 4KK6A 3NMOA 1KPLA 2HT3A 4FG6A 2H2SA 4LOUA 3EJZA 4KKCA 2HLFA 4KKLA 1KPKA 3ORGA 2FECA 2HT4A 4KJWA 4KKAA 3ND0A 3EJYA 3DETA 1OTUA 4ENEA 4KKBA 4MQXA 5HD8A 4KK8A 2EXYA 4KK9A 3Q17A 2EZ0A 2H2PA 2HTKA 2EXWA 2FEDA 1OTTA 2HT2A 4KJPA 4KJQA 1OTSA 2FEEA 2R9HA 4FTPA 4KK5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HTL A;  4KK6 A;  3NMO A;  1KPL A;  2HT3 A;  4FG6 A;  2H2S A;  4LOU A;  3EJZ A;  4KKC A;  2HLF A;  4KKL A;  1KPK A;  3ORG A;  2FEC A;  2HT4 A;  4KJW A;  4KKA A;  3ND0 A;  3EJY A;  3DET A;  1OTU A;  4ENE A;  4KKB A;  4MQX A;  5HD8 A;  4KK8 A;  2EXY A;  4KK9 A;  3Q17 A;  2EZ0 A;  2H2P A;  2HTK A;  2EXW A;  2FED A;  1OTT A;  2HT2 A;  4KJP A;  4KJQ A;  1OTS A;  2FEE A;  2R9H A;  4FTP A;  4KK5 A; 
#chains in the Genus database with same CATH topology
 2HTL A;  4KK6 A;  3NMO A;  1KPL A;  2HT3 A;  4FG6 A;  2H2S A;  4LOU A;  3EJZ A;  4KKC A;  2HLF A;  4KKL A;  1KPK A;  3ORG A;  2FEC A;  2HT4 A;  4KJW A;  4KKA A;  3ND0 A;  3EJY A;  3DET A;  1OTU A;  4ENE A;  4KKB A;  4MQX A;  5HD8 A;  4KK8 A;  2EXY A;  4KK9 A;  3Q17 A;  2EZ0 A;  2H2P A;  2HTK A;  2EXW A;  2FED A;  1OTT A;  2HT2 A;  4KJP A;  4KJQ A;  1OTS A;  2FEE A;  2R9H A;  4FTP A;  4KK5 A; 
#chains in the Genus database with same CATH homology
 2HTL A;  4KK6 A;  3NMO A;  1KPL A;  2HT3 A;  4FG6 A;  2H2S A;  4LOU A;  3EJZ A;  4KKC A;  2HLF A;  4KKL A;  1KPK A;  3ORG A;  2FEC A;  2HT4 A;  4KJW A;  4KKA A;  3ND0 A;  3EJY A;  3DET A;  1OTU A;  4ENE A;  4KKB A;  4MQX A;  5HD8 A;  4KK8 A;  2EXY A;  4KK9 A;  3Q17 A;  2EZ0 A;  2H2P A;  2HTK A;  2EXW A;  2FED A;  1OTT A;  2HT2 A;  4KJP A;  4KJQ A;  1OTS A;  2FEE A;  2R9H A;  4FTP A;  4KK5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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