1OTUA

Structure of the escherichia coli clc chloride channel e148q mutant and fab complex
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRQGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Gating the Selectivity Filter in ClC Chloride Channels
pubmed doi rcsb
molecule tags Membrane protein
source organism Escherichia coli
molecule keywords Voltage-gated ClC-type chloride channel eriC
total genus 154
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2003-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 1otuA00
2H2PA 3Q17A 2EXYA 2H2SA 4KKAA 4KJWA 4LOUA 4MQXA 5HD8A 2FEEA 4ENEA 2FEDA 2HT4A 2EZ0A 1OTUA 3DETA 4KK6A 4KKLA 4KK5A 3ORGA 4KJPA 4KK9A 1OTTA 4FG6A 1KPLA 4KJQA 4KKBA 3EJZA 2R9HA 2HTLA 4KKCA 1KPKA 2HT2A 2EXWA 2HTKA 3EJYA 2FECA 3NMOA 3ND0A 2HLFA 4FTPA 1OTSA 4KK8A 2HT3A
chains in the Genus database with same CATH superfamily
2H2PA 3Q17A 2EXYA 2H2SA 4KKAA 4KJWA 4LOUA 4MQXA 5HD8A 2FEEA 4ENEA 2FEDA 2HT4A 2EZ0A 1OTUA 3DETA 4KK6A 4KKLA 4KK5A 3ORGA 4KJPA 4KK9A 1OTTA 4FG6A 1KPLA 4KJQA 4KKBA 3EJZA 2R9HA 2HTLA 4KKCA 1KPKA 2HT2A 2EXWA 2HTKA 3EJYA 2FECA 3NMOA 3ND0A 2HLFA 4FTPA 1OTSA 4KK8A 2HT3A
chains in the Genus database with same CATH topology
2H2PA 3Q17A 2EXYA 2H2SA 4KKAA 4KJWA 4LOUA 4MQXA 5HD8A 2FEEA 4ENEA 2FEDA 2HT4A 2EZ0A 1OTUA 3DETA 4KK6A 4KKLA 4KK5A 3ORGA 4KJPA 4KK9A 1OTTA 4FG6A 1KPLA 4KJQA 4KKBA 3EJZA 2R9HA 2HTLA 4KKCA 1KPKA 2HT2A 2EXWA 2HTKA 3EJYA 2FECA 3NMOA 3ND0A 2HLFA 4FTPA 1OTSA 4KK8A 2HT3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H2P A;  3Q17 A;  2EXY A;  2H2S A;  4KKA A;  4KJW A;  4LOU A;  4MQX A;  5HD8 A;  2FEE A;  4ENE A;  2FED A;  2HT4 A;  2EZ0 A;  1OTU A;  3DET A;  4KK6 A;  4KKL A;  4KK5 A;  3ORG A;  4KJP A;  4KK9 A;  1OTT A;  4FG6 A;  1KPL A;  4KJQ A;  4KKB A;  3EJZ A;  2R9H A;  2HTL A;  4KKC A;  1KPK A;  2HT2 A;  2EXW A;  2HTK A;  3EJY A;  2FEC A;  3NMO A;  3ND0 A;  2HLF A;  4FTP A;  1OTS A;  4KK8 A;  2HT3 A; 
#chains in the Genus database with same CATH topology
 2H2P A;  3Q17 A;  2EXY A;  2H2S A;  4KKA A;  4KJW A;  4LOU A;  4MQX A;  5HD8 A;  2FEE A;  4ENE A;  2FED A;  2HT4 A;  2EZ0 A;  1OTU A;  3DET A;  4KK6 A;  4KKL A;  4KK5 A;  3ORG A;  4KJP A;  4KK9 A;  1OTT A;  4FG6 A;  1KPL A;  4KJQ A;  4KKB A;  3EJZ A;  2R9H A;  2HTL A;  4KKC A;  1KPK A;  2HT2 A;  2EXW A;  2HTK A;  3EJY A;  2FEC A;  3NMO A;  3ND0 A;  2HLF A;  4FTP A;  1OTS A;  4KK8 A;  2HT3 A; 
#chains in the Genus database with same CATH homology
 2H2P A;  3Q17 A;  2EXY A;  2H2S A;  4KKA A;  4KJW A;  4LOU A;  4MQX A;  5HD8 A;  2FEE A;  4ENE A;  2FED A;  2HT4 A;  2EZ0 A;  1OTU A;  3DET A;  4KK6 A;  4KKL A;  4KK5 A;  3ORG A;  4KJP A;  4KK9 A;  1OTT A;  4FG6 A;  1KPL A;  4KJQ A;  4KKB A;  3EJZ A;  2R9H A;  2HTL A;  4KKC A;  1KPK A;  2HT2 A;  2EXW A;  2HTK A;  3EJY A;  2FEC A;  3NMO A;  3ND0 A;  2HLF A;  4FTP A;  1OTS A;  4KK8 A;  2HT3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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