1RRI | Genus

Total Genus 30

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	30
sequence length	121
structure length	121
Chain Sequence	MQDTIFLKGMRFYGYHGALSAENEIGQIFKVDVTLKVDLSEAGRTDNVIDTVHYGEVFEEVKSIMEGKAVNLLEHLAERIANRINSQYNRVMETKVRITKENPPIPGHYDGVGIEIVRENK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization. pubmed doi rcsb
molecule keywords	Dihydroneopterin aldolase
molecule tags	Lyase
source organism	Staphylococcus aureus
total genus	30
structure length	121
sequence length	121
ec nomenclature	ec 4.1.2.25: Dihydroneopterin aldolase.
pdb deposition date	2003-12-08

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF02152	FolB	Dihydroneopterin aldolase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP Cyclohydrolase I, domain 2	1rriA00

1RS2A 4F8BA 1N3TA 4AEYA 1IS8A 2NM3A 1A9CA 1N3RA 2NM2A 4GHMA 3RZPA 4FGCA 1WURA 1N3SA 1WPLA 1FBXA 2CG8A 1A8RA 1RRWA 1RSIA 1RS4A 1WM9A 3O1KA 3UXJA 3UXVA 4UQFA 1RRIA 3BP1A 1U68A 4DU6A 1NBUA 1SQLA 3R2EA 3V9OA 1RSDA 3S19A 2O90A 1GTPA 3RJ4A 1DHNA 2DHNA 1WUQA 5FARA 1IS7A 1RRYA 4IQIA 1FB1A 5F3MA 1Z9WA 1NBUB 1B9LA 1NBUC
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1RS2 A;  4F8B A;  1N3T A;  4AEY A;  1IS8 A;  2NM3 A;  1A9C A;  1N3R A;  2NM2 A;  4GHM A;  3RZP A;  4FGC A;  1WUR A;  1N3S A;  1WPL A;  1FBX A;  2CG8 A;  1A8R A;  1RRW A;  1RSI A;  1RS4 A;  1WM9 A;  3O1K A;  3UXJ A;  3UXV A;  4UQF A;  1RRI A;  3BP1 A;  1U68 A;  4DU6 A;  1NBU A;  1SQL A;  3R2E A;  3V9O A;  1RSD A;  3S19 A;  2O90 A;  1GTP A;  3RJ4 A;  1DHN A;  2DHN A;  1WUQ A;  5FAR A;  1IS7 A;  1RRY A;  4IQI A;  1FB1 A;  5F3M A;  1Z9W A;  1NBU B;  1B9L A;  1NBU C; 
#chains in the Genus database with same CATH topology
 1RS2 A;  4F8B A;  1N3T A;  4AEY A;  1IS8 A;  2NM3 A;  1A9C A;  1N3R A;  2NM2 A;  4GHM A;  3RZP A;  4FGC A;  1WUR A;  1N3S A;  1WPL A;  1FBX A;  2CG8 A;  1A8R A;  1RRW A;  1RSI A;  1RS4 A;  1WM9 A;  3O1K A;  3UXJ A;  3UXV A;  4UQF A;  1RRI A;  3BP1 A;  1U68 A;  4DU6 A;  1NBU A;  1SQL A;  3R2E A;  3V9O A;  1RSD A;  3S19 A;  2O90 A;  1GTP A;  3RJ4 A;  1DHN A;  2DHN A;  1WUQ A;  5FAR A;  1IS7 A;  1RRY A;  4IQI A;  1FB1 A;  5F3M A;  1Z9W A;  1NBU B;  1B9L A;  1NBU C; 
#chains in the Genus database with same CATH homology
 1RS2 A;  4F8B A;  1N3T A;  4AEY A;  1IS8 A;  2NM3 A;  1A9C A;  1N3R A;  2NM2 A;  4GHM A;  3RZP A;  4FGC A;  1WUR A;  1N3S A;  1WPL A;  1FBX A;  2CG8 A;  1A8R A;  1RRW A;  1RSI A;  1RS4 A;  1WM9 A;  3O1K A;  3UXJ A;  3UXV A;  4UQF A;  1RRI A;  3BP1 A;  1U68 A;  4DU6 A;  1NBU A;  1SQL A;  3R2E A;  3V9O A;  1RSD A;  3S19 A;  2O90 A;  1GTP A;  3RJ4 A;  1DHN A;  2DHN A;  1WUQ A;  5FAR A;  1IS7 A;  1RRY A;  4IQI A;  1FB1 A;  5F3M A;  1Z9W A;  1NBU B;  1B9L A;  1NBU C;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1RRIA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations