1RS4A

Dhna, 7,8-dihydroneopterin aldolase complexed with 3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-n-(3,5-dichlorobenzyl)-benzamide
Total Genus 30

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
121
structure length
121
Chain Sequence
MQDTIFLKGMRFYGYHGALSAENEIGQIFKVDVTLKVDLSEAGRTDNVIDTVHYGEVFEEVKSIMEGKAVNLLEHLAERIANRINSQYNRVMETKVRITKENPPIPGHYDGVGIEIVRENK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYS2 (27-37)AH1 (20-25)S1 (4-14)S3 (91-100)AH2 (39-45)TI3 (88-91)AH3 (54-66)AH4 (73-87)TIV2 (100-103)S4 (112-119)TI1 (47-50)Updating...
connected with : NaN
publication title Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
pubmed doi rcsb
molecule tags Lyase
source organism Staphylococcus aureus
molecule keywords Dihydroneopterin aldolase
total genus 30
structure length 121
sequence length 121
ec nomenclature ec 4.1.2.25: Dihydroneopterin aldolase.
pdb deposition date 2003-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02152 FolB Dihydroneopterin aldolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP Cyclohydrolase I, domain 2 1rs4A00
3RZPA 3V9OA 1A8RA 1NBUC 1RSIA 1WPLA 5F3MA 1Z9WA 1A9CA 1WM9A 3BP1A 4GHMA 2O90A 1RSDA 1U68A 1WUQA 1RS4A 1SQLA 2CG8A 4DU6A 1NBUA 1RRIA 1WURA 3UXVA 1N3RA 2DHNA 4AEYA 1IS8A 3R2EA 5FARA 3UXJA 1RRWA 1RRYA 4FGCA 1N3SA 4IQIA 1RS2A 1GTPA 4F8BA 1N3TA 2NM2A 3O1KA 4UQFA 3RJ4A 3S19A 1FB1A 1DHNA 1NBUB 1B9LA 1FBXA 2NM3A 1IS7A
chains in the Genus database with same CATH superfamily
3RZPA 3V9OA 1A8RA 1NBUC 1RSIA 1WPLA 5F3MA 1Z9WA 1A9CA 1WM9A 3BP1A 4GHMA 2O90A 1RSDA 1U68A 1WUQA 1RS4A 1SQLA 2CG8A 4DU6A 1NBUA 1RRIA 1WURA 3UXVA 1N3RA 2DHNA 4AEYA 1IS8A 3R2EA 5FARA 3UXJA 1RRWA 1RRYA 4FGCA 1N3SA 4IQIA 1RS2A 1GTPA 4F8BA 1N3TA 2NM2A 3O1KA 4UQFA 3RJ4A 3S19A 1FB1A 1DHNA 1NBUB 1B9LA 1FBXA 2NM3A 1IS7A
chains in the Genus database with same CATH topology
3RZPA 3V9OA 1A8RA 1NBUC 1RSIA 1WPLA 5F3MA 1Z9WA 1A9CA 1WM9A 3BP1A 4GHMA 2O90A 1RSDA 1U68A 1WUQA 1RS4A 1SQLA 2CG8A 4DU6A 1NBUA 1RRIA 1WURA 3UXVA 1N3RA 2DHNA 4AEYA 1IS8A 3R2EA 5FARA 3UXJA 1RRWA 1RRYA 4FGCA 1N3SA 4IQIA 1RS2A 1GTPA 4F8BA 1N3TA 2NM2A 3O1KA 4UQFA 3RJ4A 3S19A 1FB1A 1DHNA 1NBUB 1B9LA 1FBXA 2NM3A 1IS7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RZP A;  3V9O A;  1A8R A;  1NBU C;  1RSI A;  1WPL A;  5F3M A;  1Z9W A;  1A9C A;  1WM9 A;  3BP1 A;  4GHM A;  2O90 A;  1RSD A;  1U68 A;  1WUQ A;  1RS4 A;  1SQL A;  2CG8 A;  4DU6 A;  1NBU A;  1RRI A;  1WUR A;  3UXV A;  1N3R A;  2DHN A;  4AEY A;  1IS8 A;  3R2E A;  5FAR A;  3UXJ A;  1RRW A;  1RRY A;  4FGC A;  1N3S A;  4IQI A;  1RS2 A;  1GTP A;  4F8B A;  1N3T A;  2NM2 A;  3O1K A;  4UQF A;  3RJ4 A;  3S19 A;  1FB1 A;  1DHN A;  1NBU B;  1B9L A;  1FBX A;  2NM3 A;  1IS7 A; 
#chains in the Genus database with same CATH topology
 3RZP A;  3V9O A;  1A8R A;  1NBU C;  1RSI A;  1WPL A;  5F3M A;  1Z9W A;  1A9C A;  1WM9 A;  3BP1 A;  4GHM A;  2O90 A;  1RSD A;  1U68 A;  1WUQ A;  1RS4 A;  1SQL A;  2CG8 A;  4DU6 A;  1NBU A;  1RRI A;  1WUR A;  3UXV A;  1N3R A;  2DHN A;  4AEY A;  1IS8 A;  3R2E A;  5FAR A;  3UXJ A;  1RRW A;  1RRY A;  4FGC A;  1N3S A;  4IQI A;  1RS2 A;  1GTP A;  4F8B A;  1N3T A;  2NM2 A;  3O1K A;  4UQF A;  3RJ4 A;  3S19 A;  1FB1 A;  1DHN A;  1NBU B;  1B9L A;  1FBX A;  2NM3 A;  1IS7 A; 
#chains in the Genus database with same CATH homology
 3RZP A;  3V9O A;  1A8R A;  1NBU C;  1RSI A;  1WPL A;  5F3M A;  1Z9W A;  1A9C A;  1WM9 A;  3BP1 A;  4GHM A;  2O90 A;  1RSD A;  1U68 A;  1WUQ A;  1RS4 A;  1SQL A;  2CG8 A;  4DU6 A;  1NBU A;  1RRI A;  1WUR A;  3UXV A;  1N3R A;  2DHN A;  4AEY A;  1IS8 A;  3R2E A;  5FAR A;  3UXJ A;  1RRW A;  1RRY A;  4FGC A;  1N3S A;  4IQI A;  1RS2 A;  1GTP A;  4F8B A;  1N3T A;  2NM2 A;  3O1K A;  4UQF A;  3RJ4 A;  3S19 A;  1FB1 A;  1DHN A;  1NBU B;  1B9L A;  1FBX A;  2NM3 A;  1IS7 A; 
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similar chains in the pdb database (?% sequence similarity)

 
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