1RSDA

Dhna complex with 3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-n-[2-(2-hydroxymethyl-phenylsulfanyl)-benzyl]-benzamide
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
121
structure length
121
Chain Sequence
MQDTIFLKGMRFYGYHGALSAENEIGQIFKVDVTLKVDLSEAGRTDNVIDTVHYGEVFEEVKSIMEGKAVNLLEHLAERIANRINSQYNRVMETKVRITKENPPIPGHYDGVGIEIVRENK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
source organism Staphylococcus aureus
publication title Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
pubmed doi rcsb
molecule keywords Dihydroneopterin aldolase
total genus 32
structure length 121
sequence length 121
ec nomenclature ec 4.1.2.25: Dihydroneopterin aldolase.
pdb deposition date 2003-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02152 FolB Dihydroneopterin aldolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1130.10 Alpha Beta 2-Layer Sandwich GTP Cyclohydrolase I, domain 2 GTP Cyclohydrolase I, domain 2 1rsdA00
3S19A 1N3SA 1WPLA 1NBUC 1FB1A 1RS2A 1RSDA 1FBXA 1WM9A 3RZPA 4AEYA 5FARA 1GTPA 2NM2A 1RRWA 4FGCA 1IS7A 2DHNA 3V9OA 1U68A 3BP1A 1SQLA 4GHMA 5F3MA 3UXJA 1NBUA 3R2EA 1N3RA 1RS4A 1A8RA 2CG8A 1N3TA 1Z9WA 2NM3A 4IQIA 1RRYA 1IS8A 1WUQA 1DHNA 1RSIA 1NBUB 3UXVA 4DU6A 3O1KA 2O90A 1B9LA 1WURA 1RRIA 4UQFA 4F8BA 1A9CA 3RJ4A
chains in the Genus database with same CATH superfamily
3S19A 1N3SA 1WPLA 1NBUC 1FB1A 1RS2A 1RSDA 1FBXA 1WM9A 3RZPA 4AEYA 5FARA 1GTPA 2NM2A 1RRWA 4FGCA 1IS7A 2DHNA 3V9OA 1U68A 3BP1A 1SQLA 4GHMA 5F3MA 3UXJA 1NBUA 3R2EA 1N3RA 1RS4A 1A8RA 2CG8A 1N3TA 1Z9WA 2NM3A 4IQIA 1RRYA 1IS8A 1WUQA 1DHNA 1RSIA 1NBUB 3UXVA 4DU6A 3O1KA 2O90A 1B9LA 1WURA 1RRIA 4UQFA 4F8BA 1A9CA 3RJ4A
chains in the Genus database with same CATH topology
3S19A 1N3SA 1WPLA 1NBUC 1FB1A 1RS2A 1RSDA 1FBXA 1WM9A 3RZPA 4AEYA 5FARA 1GTPA 2NM2A 1RRWA 4FGCA 1IS7A 2DHNA 3V9OA 1U68A 3BP1A 1SQLA 4GHMA 5F3MA 3UXJA 1NBUA 3R2EA 1N3RA 1RS4A 1A8RA 2CG8A 1N3TA 1Z9WA 2NM3A 4IQIA 1RRYA 1IS8A 1WUQA 1DHNA 1RSIA 1NBUB 3UXVA 4DU6A 3O1KA 2O90A 1B9LA 1WURA 1RRIA 4UQFA 4F8BA 1A9CA 3RJ4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S19 A;  1N3S A;  1WPL A;  1NBU C;  1FB1 A;  1RS2 A;  1RSD A;  1FBX A;  1WM9 A;  3RZP A;  4AEY A;  5FAR A;  1GTP A;  2NM2 A;  1RRW A;  4FGC A;  1IS7 A;  2DHN A;  3V9O A;  1U68 A;  3BP1 A;  1SQL A;  4GHM A;  5F3M A;  3UXJ A;  1NBU A;  3R2E A;  1N3R A;  1RS4 A;  1A8R A;  2CG8 A;  1N3T A;  1Z9W A;  2NM3 A;  4IQI A;  1RRY A;  1IS8 A;  1WUQ A;  1DHN A;  1RSI A;  1NBU B;  3UXV A;  4DU6 A;  3O1K A;  2O90 A;  1B9L A;  1WUR A;  1RRI A;  4UQF A;  4F8B A;  1A9C A;  3RJ4 A; 
#chains in the Genus database with same CATH topology
 3S19 A;  1N3S A;  1WPL A;  1NBU C;  1FB1 A;  1RS2 A;  1RSD A;  1FBX A;  1WM9 A;  3RZP A;  4AEY A;  5FAR A;  1GTP A;  2NM2 A;  1RRW A;  4FGC A;  1IS7 A;  2DHN A;  3V9O A;  1U68 A;  3BP1 A;  1SQL A;  4GHM A;  5F3M A;  3UXJ A;  1NBU A;  3R2E A;  1N3R A;  1RS4 A;  1A8R A;  2CG8 A;  1N3T A;  1Z9W A;  2NM3 A;  4IQI A;  1RRY A;  1IS8 A;  1WUQ A;  1DHN A;  1RSI A;  1NBU B;  3UXV A;  4DU6 A;  3O1K A;  2O90 A;  1B9L A;  1WUR A;  1RRI A;  4UQF A;  4F8B A;  1A9C A;  3RJ4 A; 
#chains in the Genus database with same CATH homology
 3S19 A;  1N3S A;  1WPL A;  1NBU C;  1FB1 A;  1RS2 A;  1RSD A;  1FBX A;  1WM9 A;  3RZP A;  4AEY A;  5FAR A;  1GTP A;  2NM2 A;  1RRW A;  4FGC A;  1IS7 A;  2DHN A;  3V9O A;  1U68 A;  3BP1 A;  1SQL A;  4GHM A;  5F3M A;  3UXJ A;  1NBU A;  3R2E A;  1N3R A;  1RS4 A;  1A8R A;  2CG8 A;  1N3T A;  1Z9W A;  2NM3 A;  4IQI A;  1RRY A;  1IS8 A;  1WUQ A;  1DHN A;  1RSI A;  1NBU B;  3UXV A;  4DU6 A;  3O1K A;  2O90 A;  1B9L A;  1WUR A;  1RRI A;  4UQF A;  4F8B A;  1A9C A;  3RJ4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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