1TX4A

Rho/rhogap/gdp(dot)alf4 complex
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
196
structure length
196
Chain Sequence
PLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNALHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue.
pubmed doi rcsb
molecule keywords P50-RHOGAP
molecule tags Complex(gtpase activatn/proto-oncogene)
source organism Homo sapiens
total genus 72
structure length 196
sequence length 196
ec nomenclature
pdb deposition date 1997-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00620 RhoGAP RhoGAP domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.555.10 Mainly Alpha Orthogonal Bundle Phosphatidylinositol 3-kinase; Chain A Rho GTPase activation protein 1tx4A00
3QISA 5HPYA 2OSAA 1F7CA 1TX4A 5C5SA 1PBWA 1AM4A 2QV2A 5IRCA 3MSXB 5JCPA 2MBGA 1XA6A 2EE5A 3CXLA 1OW3A 3IUGA 1RGPA 2NGRB 3FK2A 3W6RA 1GRNB 2OVJA 3BYIA 3WPQA 5JD0A 3WPSA 2XS6A 5C2JA 3KUQA 2EE4A 3EAPA
chains in the Genus database with same CATH superfamily
3QISA 5HPYA 2OSAA 1F7CA 1TX4A 5C5SA 1PBWA 1AM4A 2QV2A 5IRCA 3MSXB 5JCPA 2MBGA 1XA6A 2EE5A 3CXLA 1OW3A 3IUGA 1RGPA 2NGRB 3FK2A 3W6RA 1GRNB 2OVJA 3BYIA 3WPQA 5JD0A 3WPSA 2XS6A 5C2JA 3KUQA 2EE4A 3EAPA
chains in the Genus database with same CATH topology
3QISA 5HPYA 2OSAA 1F7CA 1TX4A 5C5SA 1PBWA 1AM4A 2QV2A 5IRCA 3MSXB 5JCPA 2MBGA 1XA6A 2EE5A 3CXLA 1OW3A 3IUGA 1RGPA 2NGRB 3FK2A 3W6RA 1GRNB 2OVJA 3BYIA 3WPQA 5JD0A 3WPSA 2XS6A 5C2JA 3KUQA 2EE4A 3EAPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QIS A;  5HPY A;  2OSA A;  1F7C A;  1TX4 A;  5C5S A;  1PBW A;  1AM4 A;  2QV2 A;  5IRC A;  3MSX B;  5JCP A;  2MBG A;  1XA6 A;  2EE5 A;  3CXL A;  1OW3 A;  3IUG A;  1RGP A;  2NGR B;  3FK2 A;  3W6R A;  1GRN B;  2OVJ A;  3BYI A;  3WPQ A;  5JD0 A;  3WPS A;  2XS6 A;  5C2J A;  3KUQ A;  2EE4 A;  3EAP A; 
#chains in the Genus database with same CATH topology
 3QIS A;  5HPY A;  2OSA A;  1F7C A;  1TX4 A;  5C5S A;  1PBW A;  1AM4 A;  2QV2 A;  5IRC A;  3MSX B;  5JCP A;  2MBG A;  1XA6 A;  2EE5 A;  3CXL A;  1OW3 A;  3IUG A;  1RGP A;  2NGR B;  3FK2 A;  3W6R A;  1GRN B;  2OVJ A;  3BYI A;  3WPQ A;  5JD0 A;  3WPS A;  2XS6 A;  5C2J A;  3KUQ A;  2EE4 A;  3EAP A; 
#chains in the Genus database with same CATH homology
 3QIS A;  5HPY A;  2OSA A;  1F7C A;  1TX4 A;  5C5S A;  1PBW A;  1AM4 A;  2QV2 A;  5IRC A;  3MSX B;  5JCP A;  2MBG A;  1XA6 A;  2EE5 A;  3CXL A;  1OW3 A;  3IUG A;  1RGP A;  2NGR B;  3FK2 A;  3W6R A;  1GRN B;  2OVJ A;  3BYI A;  3WPQ A;  5JD0 A;  3WPS A;  2XS6 A;  5C2J A;  3KUQ A;  2EE4 A;  3EAP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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