2BESA

Structure of mycobacterium tuberculosis ribose-5-phosphate isomerase, rpib, rv2465c, in complex with 4-phospho-d-erythronohydroxamic acid.
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
157
structure length
157
Chain Sequence
GMRVYLGADHAGYELKQRIIEHLKQTGHEPIDCGALRYDADDDYPAFCIAAATRTVADPGSLGIVLGGSGNGEQIAANKVPGARCALAWSVQTAALAREHNNAQLIGIGGRMHTVAEALAIVDAFVTTPWSKAQRHQRRIDILAEYERTHEAPPVPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Isomerase
molecule keywords CARBOHYDRATE-PHOSPHATE ISOMERASE
publication title Competitive Inhibitors of Mycobacterium Tuberculosis Ribose-5-Phosphate Isomerase B Reveal New Information About the Reaction Mechanism.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 57
structure length 157
sequence length 157
chains with identical sequence B, C, D, E
ec nomenclature ec 5.3.1.6: Ribose-5-phosphate isomerase.
pdb deposition date 2004-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02502 LacAB_rpiB Ribose/Galactose Isomerase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1400.10 Alpha Beta 3-Layer(aba) Sandwich Ribose 5-phosphate Isomerase B; Chain: A, Sugar-phosphate isomerase, RpiB/LacA/LacB 2besA00
2VVQA 3K7PA 2VVPA 4LFKA 4U8FA 3ONOA 5IFZA 3C5YA 2BETA 4LFLB 3SDWA 3HEEA 4LFMB 3M1PA 4EM8A 3QD5A 3K7OA 4LFNB 3K8CA 1O1XA 4LFLA 2VVOA 4LFMA 3S5PA 2VVRA 4LFNA 1NN4A 3PH3A 3K7SA 4U8EA 3PH4A 2PPWA 3SGWA 4LFKB 1USLA 2BESA 3HE8A
chains in the Genus database with same CATH superfamily
2VVQA 3K7PA 2VVPA 4LFKA 4U8FA 3ONOA 5IFZA 3C5YA 2BETA 4LFLB 3SDWA 3HEEA 4LFMB 3M1PA 4EM8A 3QD5A 3K7OA 4LFNB 3K8CA 1O1XA 4LFLA 2VVOA 4LFMA 3S5PA 2VVRA 4LFNA 1NN4A 3PH3A 3K7SA 4U8EA 3PH4A 2PPWA 3SGWA 4LFKB 1USLA 2BESA 3HE8A
chains in the Genus database with same CATH topology
2VVQA 3K7PA 2VVPA 4LFKA 4U8FA 3ONOA 5IFZA 3C5YA 2BETA 4LFLB 3SDWA 3HEEA 4LFMB 3M1PA 4EM8A 3QD5A 3K7OA 4LFNB 3K8CA 1O1XA 4LFLA 2VVOA 4LFMA 3S5PA 2VVRA 4LFNA 1NN4A 3PH3A 3K7SA 4U8EA 3PH4A 2PPWA 3SGWA 4LFKB 1USLA 2BESA 3HE8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VVQ A;  3K7P A;  2VVP A;  4LFK A;  4U8F A;  3ONO A;  5IFZ A;  3C5Y A;  2BET A;  4LFL B;  3SDW A;  3HEE A;  4LFM B;  3M1P A;  4EM8 A;  3QD5 A;  3K7O A;  4LFN B;  3K8C A;  1O1X A;  4LFL A;  2VVO A;  4LFM A;  3S5P A;  2VVR A;  4LFN A;  1NN4 A;  3PH3 A;  3K7S A;  4U8E A;  3PH4 A;  2PPW A;  3SGW A;  4LFK B;  1USL A;  2BES A;  3HE8 A; 
#chains in the Genus database with same CATH topology
 2VVQ A;  3K7P A;  2VVP A;  4LFK A;  4U8F A;  3ONO A;  5IFZ A;  3C5Y A;  2BET A;  4LFL B;  3SDW A;  3HEE A;  4LFM B;  3M1P A;  4EM8 A;  3QD5 A;  3K7O A;  4LFN B;  3K8C A;  1O1X A;  4LFL A;  2VVO A;  4LFM A;  3S5P A;  2VVR A;  4LFN A;  1NN4 A;  3PH3 A;  3K7S A;  4U8E A;  3PH4 A;  2PPW A;  3SGW A;  4LFK B;  1USL A;  2BES A;  3HE8 A; 
#chains in the Genus database with same CATH homology
 2VVQ A;  3K7P A;  2VVP A;  4LFK A;  4U8F A;  3ONO A;  5IFZ A;  3C5Y A;  2BET A;  4LFL B;  3SDW A;  3HEE A;  4LFM B;  3M1P A;  4EM8 A;  3QD5 A;  3K7O A;  4LFN B;  3K8C A;  1O1X A;  4LFL A;  2VVO A;  4LFM A;  3S5P A;  2VVR A;  4LFN A;  1NN4 A;  3PH3 A;  3K7S A;  4U8E A;  3PH4 A;  2PPW A;  3SGW A;  4LFK B;  1USL A;  2BES A;  3HE8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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