2VVQA

Crystal structure of mycobacterium tuberculosis ribose-5-phosphate isomerase b in complex with the inhibitor 5-deoxy-5-phospho-d- ribonate
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
156
structure length
156
Chain Sequence
GMRVYLGADHAGYELKQRIIEHLKQTGHEPIDCGALRYDADDDYPAFCIAAATRTVADPGSLGIVLGGSGNGEQIAANKVPGARCALAWSVQTAALAREHNNAQLIGIGGRMHTVAEALAIVDAFVTTPWSKAQRHQRRIDILAEYERTHEAPPVP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Isomerase
molecule keywords RIBOSE-5-PHOSPHATE ISOMERASE B
publication title D-Ribose-5-Phosphate Isomerase B from Escherichia Coli is Also a Functional D-Allose-6-Phosphate Isomerase, While the Mycobacterium Tuberculosis Enzyme is not.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 58
structure length 156
sequence length 156
chains with identical sequence B, C, D, E
ec nomenclature ec 5.3.1.6: Ribose-5-phosphate isomerase.
pdb deposition date 2008-06-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02502 LacAB_rpiB Ribose/Galactose Isomerase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1400.10 Alpha Beta 3-Layer(aba) Sandwich Ribose 5-phosphate Isomerase B; Chain: A, Sugar-phosphate isomerase, RpiB/LacA/LacB 2vvqA00
3K7SA 4LFKB 1O1XA 4LFNB 3S5PA 1USLA 4LFKA 4U8FA 3PH4A 3M1PA 4LFNA 3QD5A 4LFLB 4LFMB 2PPWA 1NN4A 2VVPA 2VVOA 2VVRA 3K8CA 3ONOA 2BETA 3SGWA 3K7PA 4U8EA 3HE8A 4LFLA 4LFMA 4EM8A 2VVQA 3HEEA 2BESA 3SDWA 3PH3A 5IFZA 3K7OA 3C5YA
chains in the Genus database with same CATH superfamily
3K7SA 4LFKB 1O1XA 4LFNB 3S5PA 1USLA 4LFKA 4U8FA 3PH4A 3M1PA 4LFNA 3QD5A 4LFLB 4LFMB 2PPWA 1NN4A 2VVPA 2VVOA 2VVRA 3K8CA 3ONOA 2BETA 3SGWA 3K7PA 4U8EA 3HE8A 4LFLA 4LFMA 4EM8A 2VVQA 3HEEA 2BESA 3SDWA 3PH3A 5IFZA 3K7OA 3C5YA
chains in the Genus database with same CATH topology
3K7SA 4LFKB 1O1XA 4LFNB 3S5PA 1USLA 4LFKA 4U8FA 3PH4A 3M1PA 4LFNA 3QD5A 4LFLB 4LFMB 2PPWA 1NN4A 2VVPA 2VVOA 2VVRA 3K8CA 3ONOA 2BETA 3SGWA 3K7PA 4U8EA 3HE8A 4LFLA 4LFMA 4EM8A 2VVQA 3HEEA 2BESA 3SDWA 3PH3A 5IFZA 3K7OA 3C5YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3K7S A;  4LFK B;  1O1X A;  4LFN B;  3S5P A;  1USL A;  4LFK A;  4U8F A;  3PH4 A;  3M1P A;  4LFN A;  3QD5 A;  4LFL B;  4LFM B;  2PPW A;  1NN4 A;  2VVP A;  2VVO A;  2VVR A;  3K8C A;  3ONO A;  2BET A;  3SGW A;  3K7P A;  4U8E A;  3HE8 A;  4LFL A;  4LFM A;  4EM8 A;  2VVQ A;  3HEE A;  2BES A;  3SDW A;  3PH3 A;  5IFZ A;  3K7O A;  3C5Y A; 
#chains in the Genus database with same CATH topology
 3K7S A;  4LFK B;  1O1X A;  4LFN B;  3S5P A;  1USL A;  4LFK A;  4U8F A;  3PH4 A;  3M1P A;  4LFN A;  3QD5 A;  4LFL B;  4LFM B;  2PPW A;  1NN4 A;  2VVP A;  2VVO A;  2VVR A;  3K8C A;  3ONO A;  2BET A;  3SGW A;  3K7P A;  4U8E A;  3HE8 A;  4LFL A;  4LFM A;  4EM8 A;  2VVQ A;  3HEE A;  2BES A;  3SDW A;  3PH3 A;  5IFZ A;  3K7O A;  3C5Y A; 
#chains in the Genus database with same CATH homology
 3K7S A;  4LFK B;  1O1X A;  4LFN B;  3S5P A;  1USL A;  4LFK A;  4U8F A;  3PH4 A;  3M1P A;  4LFN A;  3QD5 A;  4LFL B;  4LFM B;  2PPW A;  1NN4 A;  2VVP A;  2VVO A;  2VVR A;  3K8C A;  3ONO A;  2BET A;  3SGW A;  3K7P A;  4U8E A;  3HE8 A;  4LFL A;  4LFM A;  4EM8 A;  2VVQ A;  3HEE A;  2BES A;  3SDW A;  3PH3 A;  5IFZ A;  3K7O A;  3C5Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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