2EXWA

Crystal structure of a ecclc-fab complex in the absence of bound ions
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ion-binding properties of the ClC chloride selectivity filter.
pubmed doi rcsb
molecule tags Membrane protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter clcA
total genus 164
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2exwA00
2HTKA 3Q17A 2FECA 2FEEA 3DETA 4KJQA 4KJWA 3ORGA 2EZ0A 2HT2A 5HD8A 1OTTA 3ND0A 4KJPA 4KK5A 4KK8A 1OTSA 2H2SA 4KK6A 2HT3A 4LOUA 2EXYA 2EXWA 2HTLA 2FEDA 4MQXA 4FG6A 4KKBA 2H2PA 3EJZA 1OTUA 2HLFA 4KKCA 4FTPA 4ENEA 1KPKA 2R9HA 4KKLA 2HT4A 4KK9A 1KPLA 3NMOA 4KKAA 3EJYA
chains in the Genus database with same CATH superfamily
2HTKA 3Q17A 2FECA 2FEEA 3DETA 4KJQA 4KJWA 3ORGA 2EZ0A 2HT2A 5HD8A 1OTTA 3ND0A 4KJPA 4KK5A 4KK8A 1OTSA 2H2SA 4KK6A 2HT3A 4LOUA 2EXYA 2EXWA 2HTLA 2FEDA 4MQXA 4FG6A 4KKBA 2H2PA 3EJZA 1OTUA 2HLFA 4KKCA 4FTPA 4ENEA 1KPKA 2R9HA 4KKLA 2HT4A 4KK9A 1KPLA 3NMOA 4KKAA 3EJYA
chains in the Genus database with same CATH topology
2HTKA 3Q17A 2FECA 2FEEA 3DETA 4KJQA 4KJWA 3ORGA 2EZ0A 2HT2A 5HD8A 1OTTA 3ND0A 4KJPA 4KK5A 4KK8A 1OTSA 2H2SA 4KK6A 2HT3A 4LOUA 2EXYA 2EXWA 2HTLA 2FEDA 4MQXA 4FG6A 4KKBA 2H2PA 3EJZA 1OTUA 2HLFA 4KKCA 4FTPA 4ENEA 1KPKA 2R9HA 4KKLA 2HT4A 4KK9A 1KPLA 3NMOA 4KKAA 3EJYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HTK A;  3Q17 A;  2FEC A;  2FEE A;  3DET A;  4KJQ A;  4KJW A;  3ORG A;  2EZ0 A;  2HT2 A;  5HD8 A;  1OTT A;  3ND0 A;  4KJP A;  4KK5 A;  4KK8 A;  1OTS A;  2H2S A;  4KK6 A;  2HT3 A;  4LOU A;  2EXY A;  2EXW A;  2HTL A;  2FED A;  4MQX A;  4FG6 A;  4KKB A;  2H2P A;  3EJZ A;  1OTU A;  2HLF A;  4KKC A;  4FTP A;  4ENE A;  1KPK A;  2R9H A;  4KKL A;  2HT4 A;  4KK9 A;  1KPL A;  3NMO A;  4KKA A;  3EJY A; 
#chains in the Genus database with same CATH topology
 2HTK A;  3Q17 A;  2FEC A;  2FEE A;  3DET A;  4KJQ A;  4KJW A;  3ORG A;  2EZ0 A;  2HT2 A;  5HD8 A;  1OTT A;  3ND0 A;  4KJP A;  4KK5 A;  4KK8 A;  1OTS A;  2H2S A;  4KK6 A;  2HT3 A;  4LOU A;  2EXY A;  2EXW A;  2HTL A;  2FED A;  4MQX A;  4FG6 A;  4KKB A;  2H2P A;  3EJZ A;  1OTU A;  2HLF A;  4KKC A;  4FTP A;  4ENE A;  1KPK A;  2R9H A;  4KKL A;  2HT4 A;  4KK9 A;  1KPL A;  3NMO A;  4KKA A;  3EJY A; 
#chains in the Genus database with same CATH homology
 2HTK A;  3Q17 A;  2FEC A;  2FEE A;  3DET A;  4KJQ A;  4KJW A;  3ORG A;  2EZ0 A;  2HT2 A;  5HD8 A;  1OTT A;  3ND0 A;  4KJP A;  4KK5 A;  4KK8 A;  1OTS A;  2H2S A;  4KK6 A;  2HT3 A;  4LOU A;  2EXY A;  2EXW A;  2HTL A;  2FED A;  4MQX A;  4FG6 A;  4KKB A;  2H2P A;  3EJZ A;  1OTU A;  2HLF A;  4KKC A;  4FTP A;  4ENE A;  1KPK A;  2R9H A;  4KKL A;  2HT4 A;  4KK9 A;  1KPL A;  3NMO A;  4KKA A;  3EJY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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