2EXYA

Crystal structure of the e148q mutant of ecclc, fab complexed in absence of bound ions
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRQGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ion-binding properties of the ClC chloride selectivity filter.
pubmed doi rcsb
molecule keywords H(+)/Cl(-) exchange transporter clcA
molecule tags Membrane protein
source organism Escherichia coli
total genus 157
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2exyA00
4MQXA 2EXWA 4KK9A 4KK5A 2EZ0A 4KK6A 4KJPA 3EJYA 1OTTA 2FEEA 4FTPA 4KJQA 2HTLA 4ENEA 4KKCA 4LOUA 2FECA 4KK8A 2FEDA 1OTSA 5HD8A 3ORGA 3Q17A 2HLFA 4KKBA 2H2SA 2HT2A 2HT3A 4KKLA 3EJZA 1KPLA 2R9HA 3DETA 2HTKA 2EXYA 3ND0A 1OTUA 2H2PA 1KPKA 4KKAA 4KJWA 4FG6A 3NMOA 2HT4A
chains in the Genus database with same CATH superfamily
4MQXA 2EXWA 4KK9A 4KK5A 2EZ0A 4KK6A 4KJPA 3EJYA 1OTTA 2FEEA 4FTPA 4KJQA 2HTLA 4ENEA 4KKCA 4LOUA 2FECA 4KK8A 2FEDA 1OTSA 5HD8A 3ORGA 3Q17A 2HLFA 4KKBA 2H2SA 2HT2A 2HT3A 4KKLA 3EJZA 1KPLA 2R9HA 3DETA 2HTKA 2EXYA 3ND0A 1OTUA 2H2PA 1KPKA 4KKAA 4KJWA 4FG6A 3NMOA 2HT4A
chains in the Genus database with same CATH topology
4MQXA 2EXWA 4KK9A 4KK5A 2EZ0A 4KK6A 4KJPA 3EJYA 1OTTA 2FEEA 4FTPA 4KJQA 2HTLA 4ENEA 4KKCA 4LOUA 2FECA 4KK8A 2FEDA 1OTSA 5HD8A 3ORGA 3Q17A 2HLFA 4KKBA 2H2SA 2HT2A 2HT3A 4KKLA 3EJZA 1KPLA 2R9HA 3DETA 2HTKA 2EXYA 3ND0A 1OTUA 2H2PA 1KPKA 4KKAA 4KJWA 4FG6A 3NMOA 2HT4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MQX A;  2EXW A;  4KK9 A;  4KK5 A;  2EZ0 A;  4KK6 A;  4KJP A;  3EJY A;  1OTT A;  2FEE A;  4FTP A;  4KJQ A;  2HTL A;  4ENE A;  4KKC A;  4LOU A;  2FEC A;  4KK8 A;  2FED A;  1OTS A;  5HD8 A;  3ORG A;  3Q17 A;  2HLF A;  4KKB A;  2H2S A;  2HT2 A;  2HT3 A;  4KKL A;  3EJZ A;  1KPL A;  2R9H A;  3DET A;  2HTK A;  2EXY A;  3ND0 A;  1OTU A;  2H2P A;  1KPK A;  4KKA A;  4KJW A;  4FG6 A;  3NMO A;  2HT4 A; 
#chains in the Genus database with same CATH topology
 4MQX A;  2EXW A;  4KK9 A;  4KK5 A;  2EZ0 A;  4KK6 A;  4KJP A;  3EJY A;  1OTT A;  2FEE A;  4FTP A;  4KJQ A;  2HTL A;  4ENE A;  4KKC A;  4LOU A;  2FEC A;  4KK8 A;  2FED A;  1OTS A;  5HD8 A;  3ORG A;  3Q17 A;  2HLF A;  4KKB A;  2H2S A;  2HT2 A;  2HT3 A;  4KKL A;  3EJZ A;  1KPL A;  2R9H A;  3DET A;  2HTK A;  2EXY A;  3ND0 A;  1OTU A;  2H2P A;  1KPK A;  4KKA A;  4KJW A;  4FG6 A;  3NMO A;  2HT4 A; 
#chains in the Genus database with same CATH homology
 4MQX A;  2EXW A;  4KK9 A;  4KK5 A;  2EZ0 A;  4KK6 A;  4KJP A;  3EJY A;  1OTT A;  2FEE A;  4FTP A;  4KJQ A;  2HTL A;  4ENE A;  4KKC A;  4LOU A;  2FEC A;  4KK8 A;  2FED A;  1OTS A;  5HD8 A;  3ORG A;  3Q17 A;  2HLF A;  4KKB A;  2H2S A;  2HT2 A;  2HT3 A;  4KKL A;  3EJZ A;  1KPL A;  2R9H A;  3DET A;  2HTK A;  2EXY A;  3ND0 A;  1OTU A;  2H2P A;  1KPK A;  4KKA A;  4KJW A;  4FG6 A;  3NMO A;  2HT4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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