2EXYA

Crystal structure of the e148q mutant of ecclc, fab complexed in absence of bound ions
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRQGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ion-binding properties of the ClC chloride selectivity filter.
pubmed doi rcsb
molecule tags Membrane protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter clcA
total genus 157
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2exyA00
5HD8A 2HT3A 2EXYA 1KPKA 2HTKA 4ENEA 3NMOA 1OTSA 1KPLA 2EXWA 2HTLA 4KKCA 4KKAA 3ORGA 3EJZA 3Q17A 1OTTA 2R9HA 2H2SA 2HLFA 2FEDA 4KK8A 4FTPA 4KK6A 2FEEA 4FG6A 4KK9A 3ND0A 3EJYA 1OTUA 2EZ0A 2HT4A 4LOUA 4KJPA 4KKBA 2FECA 4KJQA 4KK5A 4MQXA 2H2PA 4KJWA 3DETA 2HT2A 4KKLA
chains in the Genus database with same CATH superfamily
5HD8A 2HT3A 2EXYA 1KPKA 2HTKA 4ENEA 3NMOA 1OTSA 1KPLA 2EXWA 2HTLA 4KKCA 4KKAA 3ORGA 3EJZA 3Q17A 1OTTA 2R9HA 2H2SA 2HLFA 2FEDA 4KK8A 4FTPA 4KK6A 2FEEA 4FG6A 4KK9A 3ND0A 3EJYA 1OTUA 2EZ0A 2HT4A 4LOUA 4KJPA 4KKBA 2FECA 4KJQA 4KK5A 4MQXA 2H2PA 4KJWA 3DETA 2HT2A 4KKLA
chains in the Genus database with same CATH topology
5HD8A 2HT3A 2EXYA 1KPKA 2HTKA 4ENEA 3NMOA 1OTSA 1KPLA 2EXWA 2HTLA 4KKCA 4KKAA 3ORGA 3EJZA 3Q17A 1OTTA 2R9HA 2H2SA 2HLFA 2FEDA 4KK8A 4FTPA 4KK6A 2FEEA 4FG6A 4KK9A 3ND0A 3EJYA 1OTUA 2EZ0A 2HT4A 4LOUA 4KJPA 4KKBA 2FECA 4KJQA 4KK5A 4MQXA 2H2PA 4KJWA 3DETA 2HT2A 4KKLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HD8 A;  2HT3 A;  2EXY A;  1KPK A;  2HTK A;  4ENE A;  3NMO A;  1OTS A;  1KPL A;  2EXW A;  2HTL A;  4KKC A;  4KKA A;  3ORG A;  3EJZ A;  3Q17 A;  1OTT A;  2R9H A;  2H2S A;  2HLF A;  2FED A;  4KK8 A;  4FTP A;  4KK6 A;  2FEE A;  4FG6 A;  4KK9 A;  3ND0 A;  3EJY A;  1OTU A;  2EZ0 A;  2HT4 A;  4LOU A;  4KJP A;  4KKB A;  2FEC A;  4KJQ A;  4KK5 A;  4MQX A;  2H2P A;  4KJW A;  3DET A;  2HT2 A;  4KKL A; 
#chains in the Genus database with same CATH topology
 5HD8 A;  2HT3 A;  2EXY A;  1KPK A;  2HTK A;  4ENE A;  3NMO A;  1OTS A;  1KPL A;  2EXW A;  2HTL A;  4KKC A;  4KKA A;  3ORG A;  3EJZ A;  3Q17 A;  1OTT A;  2R9H A;  2H2S A;  2HLF A;  2FED A;  4KK8 A;  4FTP A;  4KK6 A;  2FEE A;  4FG6 A;  4KK9 A;  3ND0 A;  3EJY A;  1OTU A;  2EZ0 A;  2HT4 A;  4LOU A;  4KJP A;  4KKB A;  2FEC A;  4KJQ A;  4KK5 A;  4MQX A;  2H2P A;  4KJW A;  3DET A;  2HT2 A;  4KKL A; 
#chains in the Genus database with same CATH homology
 5HD8 A;  2HT3 A;  2EXY A;  1KPK A;  2HTK A;  4ENE A;  3NMO A;  1OTS A;  1KPL A;  2EXW A;  2HTL A;  4KKC A;  4KKA A;  3ORG A;  3EJZ A;  3Q17 A;  1OTT A;  2R9H A;  2H2S A;  2HLF A;  2FED A;  4KK8 A;  4FTP A;  4KK6 A;  2FEE A;  4FG6 A;  4KK9 A;  3ND0 A;  3EJY A;  1OTU A;  2EZ0 A;  2HT4 A;  4LOU A;  4KJP A;  4KKB A;  2FEC A;  4KJQ A;  4KK5 A;  4MQX A;  2H2P A;  4KJW A;  3DET A;  2HT2 A;  4KKL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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