2EZ0A

Crystal structure of the s107a/e148q/y445a mutant of ecclc, in complex with a fab fragment
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGAGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRQGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLASAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ion-binding properties of the ClC chloride selectivity filter.
pubmed doi rcsb
molecule tags Membrane protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter clcA
total genus 155
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-11-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2ez0A00
2HT3A 1OTTA 1OTSA 4KKAA 1KPKA 4KK6A 3Q17A 4KJQA 4KKBA 4KK5A 2EXWA 2EZ0A 3ND0A 2HT2A 3DETA 2R9HA 2FEDA 3EJZA 1KPLA 4MQXA 4FTPA 4FG6A 2FECA 5HD8A 2HT4A 2HTLA 1OTUA 2H2SA 2HLFA 2HTKA 4KJPA 4KJWA 2H2PA 4KK9A 4KK8A 3EJYA 2EXYA 3ORGA 4KKCA 4LOUA 4ENEA 4KKLA 2FEEA 3NMOA
chains in the Genus database with same CATH superfamily
2HT3A 1OTTA 1OTSA 4KKAA 1KPKA 4KK6A 3Q17A 4KJQA 4KKBA 4KK5A 2EXWA 2EZ0A 3ND0A 2HT2A 3DETA 2R9HA 2FEDA 3EJZA 1KPLA 4MQXA 4FTPA 4FG6A 2FECA 5HD8A 2HT4A 2HTLA 1OTUA 2H2SA 2HLFA 2HTKA 4KJPA 4KJWA 2H2PA 4KK9A 4KK8A 3EJYA 2EXYA 3ORGA 4KKCA 4LOUA 4ENEA 4KKLA 2FEEA 3NMOA
chains in the Genus database with same CATH topology
2HT3A 1OTTA 1OTSA 4KKAA 1KPKA 4KK6A 3Q17A 4KJQA 4KKBA 4KK5A 2EXWA 2EZ0A 3ND0A 2HT2A 3DETA 2R9HA 2FEDA 3EJZA 1KPLA 4MQXA 4FTPA 4FG6A 2FECA 5HD8A 2HT4A 2HTLA 1OTUA 2H2SA 2HLFA 2HTKA 4KJPA 4KJWA 2H2PA 4KK9A 4KK8A 3EJYA 2EXYA 3ORGA 4KKCA 4LOUA 4ENEA 4KKLA 2FEEA 3NMOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HT3 A;  1OTT A;  1OTS A;  4KKA A;  1KPK A;  4KK6 A;  3Q17 A;  4KJQ A;  4KKB A;  4KK5 A;  2EXW A;  2EZ0 A;  3ND0 A;  2HT2 A;  3DET A;  2R9H A;  2FED A;  3EJZ A;  1KPL A;  4MQX A;  4FTP A;  4FG6 A;  2FEC A;  5HD8 A;  2HT4 A;  2HTL A;  1OTU A;  2H2S A;  2HLF A;  2HTK A;  4KJP A;  4KJW A;  2H2P A;  4KK9 A;  4KK8 A;  3EJY A;  2EXY A;  3ORG A;  4KKC A;  4LOU A;  4ENE A;  4KKL A;  2FEE A;  3NMO A; 
#chains in the Genus database with same CATH topology
 2HT3 A;  1OTT A;  1OTS A;  4KKA A;  1KPK A;  4KK6 A;  3Q17 A;  4KJQ A;  4KKB A;  4KK5 A;  2EXW A;  2EZ0 A;  3ND0 A;  2HT2 A;  3DET A;  2R9H A;  2FED A;  3EJZ A;  1KPL A;  4MQX A;  4FTP A;  4FG6 A;  2FEC A;  5HD8 A;  2HT4 A;  2HTL A;  1OTU A;  2H2S A;  2HLF A;  2HTK A;  4KJP A;  4KJW A;  2H2P A;  4KK9 A;  4KK8 A;  3EJY A;  2EXY A;  3ORG A;  4KKC A;  4LOU A;  4ENE A;  4KKL A;  2FEE A;  3NMO A; 
#chains in the Genus database with same CATH homology
 2HT3 A;  1OTT A;  1OTS A;  4KKA A;  1KPK A;  4KK6 A;  3Q17 A;  4KJQ A;  4KKB A;  4KK5 A;  2EXW A;  2EZ0 A;  3ND0 A;  2HT2 A;  3DET A;  2R9H A;  2FED A;  3EJZ A;  1KPL A;  4MQX A;  4FTP A;  4FG6 A;  2FEC A;  5HD8 A;  2HT4 A;  2HTL A;  1OTU A;  2H2S A;  2HLF A;  2HTK A;  4KJP A;  4KJW A;  2H2P A;  4KK9 A;  4KK8 A;  3EJY A;  2EXY A;  3ORG A;  4KKC A;  4LOU A;  4ENE A;  4KKL A;  2FEE A;  3NMO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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