2HLFA

Structure of the escherichis coli clc chloride channel y445e mutant and fab complex
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLESAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger
pubmed doi rcsb
molecule tags Proton transport,membrane protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter clcA
total genus 170
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-07-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2hlfA00
3ORGA 4LOUA 1KPLA 5HD8A 2FEDA 4KK6A 4ENEA 2FEEA 2EZ0A 2HTLA 2HLFA 1OTSA 2HT3A 3EJYA 3NMOA 1OTTA 2H2SA 4KK5A 1OTUA 2HT4A 1KPKA 4KKAA 4KKCA 4KK9A 4FG6A 2FECA 4KJQA 3ND0A 2EXYA 4KJWA 3Q17A 2HTKA 3DETA 3EJZA 4KJPA 4KKBA 4KKLA 2H2PA 4KK8A 2HT2A 2EXWA 2R9HA 4MQXA 4FTPA
chains in the Genus database with same CATH superfamily
3ORGA 4LOUA 1KPLA 5HD8A 2FEDA 4KK6A 4ENEA 2FEEA 2EZ0A 2HTLA 2HLFA 1OTSA 2HT3A 3EJYA 3NMOA 1OTTA 2H2SA 4KK5A 1OTUA 2HT4A 1KPKA 4KKAA 4KKCA 4KK9A 4FG6A 2FECA 4KJQA 3ND0A 2EXYA 4KJWA 3Q17A 2HTKA 3DETA 3EJZA 4KJPA 4KKBA 4KKLA 2H2PA 4KK8A 2HT2A 2EXWA 2R9HA 4MQXA 4FTPA
chains in the Genus database with same CATH topology
3ORGA 4LOUA 1KPLA 5HD8A 2FEDA 4KK6A 4ENEA 2FEEA 2EZ0A 2HTLA 2HLFA 1OTSA 2HT3A 3EJYA 3NMOA 1OTTA 2H2SA 4KK5A 1OTUA 2HT4A 1KPKA 4KKAA 4KKCA 4KK9A 4FG6A 2FECA 4KJQA 3ND0A 2EXYA 4KJWA 3Q17A 2HTKA 3DETA 3EJZA 4KJPA 4KKBA 4KKLA 2H2PA 4KK8A 2HT2A 2EXWA 2R9HA 4MQXA 4FTPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ORG A;  4LOU A;  1KPL A;  5HD8 A;  2FED A;  4KK6 A;  4ENE A;  2FEE A;  2EZ0 A;  2HTL A;  2HLF A;  1OTS A;  2HT3 A;  3EJY A;  3NMO A;  1OTT A;  2H2S A;  4KK5 A;  1OTU A;  2HT4 A;  1KPK A;  4KKA A;  4KKC A;  4KK9 A;  4FG6 A;  2FEC A;  4KJQ A;  3ND0 A;  2EXY A;  4KJW A;  3Q17 A;  2HTK A;  3DET A;  3EJZ A;  4KJP A;  4KKB A;  4KKL A;  2H2P A;  4KK8 A;  2HT2 A;  2EXW A;  2R9H A;  4MQX A;  4FTP A; 
#chains in the Genus database with same CATH topology
 3ORG A;  4LOU A;  1KPL A;  5HD8 A;  2FED A;  4KK6 A;  4ENE A;  2FEE A;  2EZ0 A;  2HTL A;  2HLF A;  1OTS A;  2HT3 A;  3EJY A;  3NMO A;  1OTT A;  2H2S A;  4KK5 A;  1OTU A;  2HT4 A;  1KPK A;  4KKA A;  4KKC A;  4KK9 A;  4FG6 A;  2FEC A;  4KJQ A;  3ND0 A;  2EXY A;  4KJW A;  3Q17 A;  2HTK A;  3DET A;  3EJZ A;  4KJP A;  4KKB A;  4KKL A;  2H2P A;  4KK8 A;  2HT2 A;  2EXW A;  2R9H A;  4MQX A;  4FTP A; 
#chains in the Genus database with same CATH homology
 3ORG A;  4LOU A;  1KPL A;  5HD8 A;  2FED A;  4KK6 A;  4ENE A;  2FEE A;  2EZ0 A;  2HTL A;  2HLF A;  1OTS A;  2HT3 A;  3EJY A;  3NMO A;  1OTT A;  2H2S A;  4KK5 A;  1OTU A;  2HT4 A;  1KPK A;  4KKA A;  4KKC A;  4KK9 A;  4FG6 A;  2FEC A;  4KJQ A;  3ND0 A;  2EXY A;  4KJW A;  3Q17 A;  2HTK A;  3DET A;  3EJZ A;  4KJP A;  4KKB A;  4KKL A;  2H2P A;  4KK8 A;  2HT2 A;  2EXW A;  2R9H A;  4MQX A;  4FTP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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