2HT2A

Structure of the escherichia coli clc chloride channel y445h mutant and fab complex
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLHSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger.
pubmed doi rcsb
molecule tags Membrane protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter clcA
total genus 167
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2ht2A00
2R9HA 1OTTA 4KKBA 1KPLA 3EJZA 3ND0A 4ENEA 4KJQA 3ORGA 2H2SA 4KJWA 1OTSA 2EXYA 2H2PA 2HT4A 4KK9A 2HT3A 2HLFA 4MQXA 4KJPA 4KKAA 3Q17A 4FTPA 1OTUA 2FEEA 2FEDA 4KKCA 2HTLA 1KPKA 2EZ0A 2HTKA 3DETA 3EJYA 4KKLA 4KK5A 2HT2A 2EXWA 5HD8A 3NMOA 4KK6A 4FG6A 4LOUA 4KK8A 2FECA
chains in the Genus database with same CATH superfamily
2R9HA 1OTTA 4KKBA 1KPLA 3EJZA 3ND0A 4ENEA 4KJQA 3ORGA 2H2SA 4KJWA 1OTSA 2EXYA 2H2PA 2HT4A 4KK9A 2HT3A 2HLFA 4MQXA 4KJPA 4KKAA 3Q17A 4FTPA 1OTUA 2FEEA 2FEDA 4KKCA 2HTLA 1KPKA 2EZ0A 2HTKA 3DETA 3EJYA 4KKLA 4KK5A 2HT2A 2EXWA 5HD8A 3NMOA 4KK6A 4FG6A 4LOUA 4KK8A 2FECA
chains in the Genus database with same CATH topology
2R9HA 1OTTA 4KKBA 1KPLA 3EJZA 3ND0A 4ENEA 4KJQA 3ORGA 2H2SA 4KJWA 1OTSA 2EXYA 2H2PA 2HT4A 4KK9A 2HT3A 2HLFA 4MQXA 4KJPA 4KKAA 3Q17A 4FTPA 1OTUA 2FEEA 2FEDA 4KKCA 2HTLA 1KPKA 2EZ0A 2HTKA 3DETA 3EJYA 4KKLA 4KK5A 2HT2A 2EXWA 5HD8A 3NMOA 4KK6A 4FG6A 4LOUA 4KK8A 2FECA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2R9H A;  1OTT A;  4KKB A;  1KPL A;  3EJZ A;  3ND0 A;  4ENE A;  4KJQ A;  3ORG A;  2H2S A;  4KJW A;  1OTS A;  2EXY A;  2H2P A;  2HT4 A;  4KK9 A;  2HT3 A;  2HLF A;  4MQX A;  4KJP A;  4KKA A;  3Q17 A;  4FTP A;  1OTU A;  2FEE A;  2FED A;  4KKC A;  2HTL A;  1KPK A;  2EZ0 A;  2HTK A;  3DET A;  3EJY A;  4KKL A;  4KK5 A;  2HT2 A;  2EXW A;  5HD8 A;  3NMO A;  4KK6 A;  4FG6 A;  4LOU A;  4KK8 A;  2FEC A; 
#chains in the Genus database with same CATH topology
 2R9H A;  1OTT A;  4KKB A;  1KPL A;  3EJZ A;  3ND0 A;  4ENE A;  4KJQ A;  3ORG A;  2H2S A;  4KJW A;  1OTS A;  2EXY A;  2H2P A;  2HT4 A;  4KK9 A;  2HT3 A;  2HLF A;  4MQX A;  4KJP A;  4KKA A;  3Q17 A;  4FTP A;  1OTU A;  2FEE A;  2FED A;  4KKC A;  2HTL A;  1KPK A;  2EZ0 A;  2HTK A;  3DET A;  3EJY A;  4KKL A;  4KK5 A;  2HT2 A;  2EXW A;  5HD8 A;  3NMO A;  4KK6 A;  4FG6 A;  4LOU A;  4KK8 A;  2FEC A; 
#chains in the Genus database with same CATH homology
 2R9H A;  1OTT A;  4KKB A;  1KPL A;  3EJZ A;  3ND0 A;  4ENE A;  4KJQ A;  3ORG A;  2H2S A;  4KJW A;  1OTS A;  2EXY A;  2H2P A;  2HT4 A;  4KK9 A;  2HT3 A;  2HLF A;  4MQX A;  4KJP A;  4KKA A;  3Q17 A;  4FTP A;  1OTU A;  2FEE A;  2FED A;  4KKC A;  2HTL A;  1KPK A;  2EZ0 A;  2HTK A;  3DET A;  3EJY A;  4KKL A;  4KK5 A;  2HT2 A;  2EXW A;  5HD8 A;  3NMO A;  4KK6 A;  4FG6 A;  4LOU A;  4KK8 A;  2FEC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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