2HTKA

Structure of the escherichia coli clc chloride channel y445a mutant and fab complex
Total Genus 166
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
166
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLASAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synergism between halide binding and proton transport in a CLC-type exchanger
pubmed doi rcsb
molecule tags Membrane protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter clcA
total genus 166
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-07-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2htkA00
2HT3A 1OTUA 1KPLA 2EXYA 4KJQA 4KJWA 2EXWA 3EJYA 4KKCA 1OTSA 3EJZA 4LOUA 3DETA 2HTLA 1OTTA 3NMOA 2HT2A 4KKAA 4MQXA 2H2SA 4KJPA 2HLFA 4KK8A 4ENEA 4KK6A 4FTPA 4KKLA 2HTKA 3Q17A 2FECA 2EZ0A 2H2PA 1KPKA 4FG6A 4KKBA 2FEEA 2HT4A 4KK9A 4KK5A 2FEDA 3ND0A 5HD8A 2R9HA 3ORGA
chains in the Genus database with same CATH superfamily
2HT3A 1OTUA 1KPLA 2EXYA 4KJQA 4KJWA 2EXWA 3EJYA 4KKCA 1OTSA 3EJZA 4LOUA 3DETA 2HTLA 1OTTA 3NMOA 2HT2A 4KKAA 4MQXA 2H2SA 4KJPA 2HLFA 4KK8A 4ENEA 4KK6A 4FTPA 4KKLA 2HTKA 3Q17A 2FECA 2EZ0A 2H2PA 1KPKA 4FG6A 4KKBA 2FEEA 2HT4A 4KK9A 4KK5A 2FEDA 3ND0A 5HD8A 2R9HA 3ORGA
chains in the Genus database with same CATH topology
2HT3A 1OTUA 1KPLA 2EXYA 4KJQA 4KJWA 2EXWA 3EJYA 4KKCA 1OTSA 3EJZA 4LOUA 3DETA 2HTLA 1OTTA 3NMOA 2HT2A 4KKAA 4MQXA 2H2SA 4KJPA 2HLFA 4KK8A 4ENEA 4KK6A 4FTPA 4KKLA 2HTKA 3Q17A 2FECA 2EZ0A 2H2PA 1KPKA 4FG6A 4KKBA 2FEEA 2HT4A 4KK9A 4KK5A 2FEDA 3ND0A 5HD8A 2R9HA 3ORGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HT3 A;  1OTU A;  1KPL A;  2EXY A;  4KJQ A;  4KJW A;  2EXW A;  3EJY A;  4KKC A;  1OTS A;  3EJZ A;  4LOU A;  3DET A;  2HTL A;  1OTT A;  3NMO A;  2HT2 A;  4KKA A;  4MQX A;  2H2S A;  4KJP A;  2HLF A;  4KK8 A;  4ENE A;  4KK6 A;  4FTP A;  4KKL A;  2HTK A;  3Q17 A;  2FEC A;  2EZ0 A;  2H2P A;  1KPK A;  4FG6 A;  4KKB A;  2FEE A;  2HT4 A;  4KK9 A;  4KK5 A;  2FED A;  3ND0 A;  5HD8 A;  2R9H A;  3ORG A; 
#chains in the Genus database with same CATH topology
 2HT3 A;  1OTU A;  1KPL A;  2EXY A;  4KJQ A;  4KJW A;  2EXW A;  3EJY A;  4KKC A;  1OTS A;  3EJZ A;  4LOU A;  3DET A;  2HTL A;  1OTT A;  3NMO A;  2HT2 A;  4KKA A;  4MQX A;  2H2S A;  4KJP A;  2HLF A;  4KK8 A;  4ENE A;  4KK6 A;  4FTP A;  4KKL A;  2HTK A;  3Q17 A;  2FEC A;  2EZ0 A;  2H2P A;  1KPK A;  4FG6 A;  4KKB A;  2FEE A;  2HT4 A;  4KK9 A;  4KK5 A;  2FED A;  3ND0 A;  5HD8 A;  2R9H A;  3ORG A; 
#chains in the Genus database with same CATH homology
 2HT3 A;  1OTU A;  1KPL A;  2EXY A;  4KJQ A;  4KJW A;  2EXW A;  3EJY A;  4KKC A;  1OTS A;  3EJZ A;  4LOU A;  3DET A;  2HTL A;  1OTT A;  3NMO A;  2HT2 A;  4KKA A;  4MQX A;  2H2S A;  4KJP A;  2HLF A;  4KK8 A;  4ENE A;  4KK6 A;  4FTP A;  4KKL A;  2HTK A;  3Q17 A;  2FEC A;  2EZ0 A;  2H2P A;  1KPK A;  4FG6 A;  4KKB A;  2FEE A;  2HT4 A;  4KK9 A;  4KK5 A;  2FED A;  3ND0 A;  5HD8 A;  2R9H A;  3ORG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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