2LEFA

Lef1 hmg domain (from mouse), complexed with dna (15bp), nmr, 12 structures
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
86
structure length
86
Chain Sequence
MHIKKPLNAFMLYMKEMRANVVAESTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for DNA bending by the architectural transcription factor LEF-1.
pubmed doi rcsb
molecule tags Gene regulation/dna
source organism Mus musculus
molecule keywords DNA (5'-D(*CP*AP*CP*CP*CP*TP*TP*TP*GP*AP*AP*GP*CP*TP*C)-3')
total genus 30
structure length 86
sequence length 86
ec nomenclature
pdb deposition date 1998-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00505 HMG_box HMG (high mobility group) box
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.30.10 Mainly Alpha Orthogonal Bundle DNA Binding (I), subunit A High mobility group box domain 2lefA00
2EQZA 1HSMA 1WZ6A 1AABA 1CG7A 1K99A 4Y60C 1NHNA 1WGFA 4NODA 4QR9A 1LWMA 2LHJA 1J3CA 3F27D 1J46A 2LY4A 3FGHA 2LE4A 2YULA 3U2BC 2CRJA 2D7LA 2YQIA 2RTUA 1E7JA 1V64A 1WXLA 1HMEA 1HSNA 2CO9A 2HDZA 2GZKA 1HMFA 1GT0D 1J3DA 1V63A 4EUWA 1HRZA 2CS1A 1J47A 3TMMA 2E6OA 1CKTA 1QRVA 2YRQA 3NM9A 1J3XA 1L8ZA 1O4XB 2CTOA 2LEFA 1L8YA 1HMAA 1NHMA 2YUKA 4A3NA 1HRYA 1I11A 4NNUA 4S2QD 3TQ6A 1J5NA
chains in the Genus database with same CATH superfamily
2EQZA 1HSMA 4KQEA 1WZ6A 1AABA 1CG7A 3ABRB 4Y60C 1NHNA 1WGFA 2VSFA 4NODA 1K99A 4QR9A 1LWMA 2LHJA 3ABOB 1J3CA 3F27D 5H8WA 1J46A 2LY4A 3FGHA 2LE4A 2YULA 3U2BC 2CRJA 2D7LA 2YQIA 4A15A 2RTUA 3ABSB 1E7JA 1V64A 1WXLA 1HMEA 1HSNA 2CO9A 2HDZA 2GZKA 1HMFA 1GT0D 1J3DA 1V63A 4EUWA 1HRZA 2CS1A 1J47A 3TMMA 2E6OA 1CKTA 1QRVA 2YRQA 3NM9A 1J3XA 1L8ZA 1O4XB 2CTOA 2LEFA 1L8YA 1HMAA 1NHMA 2YUKA 4A3NA 1HRYA 1I11A 4NNUA 3AO0B 4S2QD 3ANYB 3TQ6A 1J5NA
chains in the Genus database with same CATH topology
2EQZA 1HSMA 1WZ6A 1AABA 1CG7A 1K99A 4Y60C 1NHNA 1WGFA 4NODA 4QR9A 1LWMA 2LHJA 1J3CA 3F27D 1J46A 2LY4A 3FGHA 2LE4A 2YULA 3U2BC 2CRJA 2D7LA 2YQIA 2RTUA 1E7JA 1V64A 1WXLA 1HMEA 1HSNA 2CO9A 2HDZA 2GZKA 1HMFA 1GT0D 1J3DA 1V63A 4EUWA 1HRZA 2CS1A 1J47A 3TMMA 2E6OA 1CKTA 1QRVA 2YRQA 3NM9A 1J3XA 1L8ZA 1O4XB 2CTOA 2LEFA 1L8YA 1HMAA 1NHMA 2YUKA 4A3NA 1HRYA 1I11A 4NNUA 4S2QD 3TQ6A 1J5NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EQZ A;  1HSM A;  1WZ6 A;  1AAB A;  1CG7 A;  1K99 A;  4Y60 C;  1NHN A;  1WGF A;  4NOD A;  4QR9 A;  1LWM A;  2LHJ A;  1J3C A;  3F27 D;  1J46 A;  2LY4 A;  3FGH A;  2LE4 A;  2YUL A;  3U2B C;  2CRJ A;  2D7L A;  2YQI A;  2RTU A;  1E7J A;  1V64 A;  1WXL A;  1HME A;  1HSN A;  2CO9 A;  2HDZ A;  2GZK A;  1HMF A;  1GT0 D;  1J3D A;  1V63 A;  4EUW A;  1HRZ A;  2CS1 A;  1J47 A;  3TMM A;  2E6O A;  1CKT A;  1QRV A;  2YRQ A;  3NM9 A;  1J3X A;  1L8Z A;  1O4X B;  2CTO A;  2LEF A;  1L8Y A;  1HMA A;  1NHM A;  2YUK A;  4A3N A;  1HRY A;  1I11 A;  4NNU A;  4S2Q D;  3TQ6 A;  1J5N A; 
#chains in the Genus database with same CATH topology
 2EQZ A;  1HSM A;  4KQE A;  1WZ6 A;  1AAB A;  1CG7 A;  3ABR B;  4Y60 C;  1NHN A;  1WGF A;  2VSF A;  4NOD A;  1K99 A;  4QR9 A;  1LWM A;  2LHJ A;  3ABO B;  1J3C A;  3F27 D;  5H8W A;  1J46 A;  2LY4 A;  3FGH A;  2LE4 A;  2YUL A;  3U2B C;  2CRJ A;  2D7L A;  2YQI A;  4A15 A;  2RTU A;  3ABS B;  1E7J A;  1V64 A;  1WXL A;  1HME A;  1HSN A;  2CO9 A;  2HDZ A;  2GZK A;  1HMF A;  1GT0 D;  1J3D A;  1V63 A;  4EUW A;  1HRZ A;  2CS1 A;  1J47 A;  3TMM A;  2E6O A;  1CKT A;  1QRV A;  2YRQ A;  3NM9 A;  1J3X A;  1L8Z A;  1O4X B;  2CTO A;  2LEF A;  1L8Y A;  1HMA A;  1NHM A;  2YUK A;  4A3N A;  1HRY A;  1I11 A;  4NNU A;  3AO0 B;  4S2Q D;  3ANY B;  3TQ6 A;  1J5N A; 
#chains in the Genus database with same CATH homology
 2EQZ A;  1HSM A;  1WZ6 A;  1AAB A;  1CG7 A;  1K99 A;  4Y60 C;  1NHN A;  1WGF A;  4NOD A;  4QR9 A;  1LWM A;  2LHJ A;  1J3C A;  3F27 D;  1J46 A;  2LY4 A;  3FGH A;  2LE4 A;  2YUL A;  3U2B C;  2CRJ A;  2D7L A;  2YQI A;  2RTU A;  1E7J A;  1V64 A;  1WXL A;  1HME A;  1HSN A;  2CO9 A;  2HDZ A;  2GZK A;  1HMF A;  1GT0 D;  1J3D A;  1V63 A;  4EUW A;  1HRZ A;  2CS1 A;  1J47 A;  3TMM A;  2E6O A;  1CKT A;  1QRV A;  2YRQ A;  3NM9 A;  1J3X A;  1L8Z A;  1O4X B;  2CTO A;  2LEF A;  1L8Y A;  1HMA A;  1NHM A;  2YUK A;  4A3N A;  1HRY A;  1I11 A;  4NNU A;  4S2Q D;  3TQ6 A;  1J5N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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