2NGRB

Transition state complex for gtp hydrolysis by cdc42: comparisons of the high resolution structures for cdc42 bound to the active and catalytically compromised forms of the cdc42-gap.
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
196
structure length
196
Chain Sequence
LPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFARSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP.
pubmed doi rcsb
molecule keywords PROTEIN (GTP BINDING PROTEIN (G25K))
molecule tags Hydrolase
source organism Homo sapiens
total genus 71
structure length 196
sequence length 196
ec nomenclature
pdb deposition date 1998-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00620 RhoGAP RhoGAP domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.555.10 Mainly Alpha Orthogonal Bundle Phosphatidylinositol 3-kinase; Chain A Rho GTPase activation protein 2ngrB00
2EE5A 5JD0A 1AM4A 3EAPA 5C5SA 3IUGA 3WPSA 3KUQA 1OW3A 2XS6A 2OSAA 1PBWA 2MBGA 2NGRB 3QISA 5C2JA 5JCPA 5IRCA 1F7CA 2EE4A 1XA6A 2QV2A 3FK2A 3MSXB 1GRNB 1TX4A 3W6RA 2OVJA 5HPYA 1RGPA 3CXLA 3WPQA 3BYIA
chains in the Genus database with same CATH superfamily
2EE5A 5JD0A 1AM4A 3EAPA 5C5SA 3IUGA 3WPSA 3KUQA 1OW3A 2XS6A 2OSAA 1PBWA 2MBGA 2NGRB 3QISA 5C2JA 5JCPA 5IRCA 1F7CA 2EE4A 1XA6A 2QV2A 3FK2A 3MSXB 1GRNB 1TX4A 3W6RA 2OVJA 5HPYA 1RGPA 3CXLA 3WPQA 3BYIA
chains in the Genus database with same CATH topology
2EE5A 5JD0A 1AM4A 3EAPA 5C5SA 3IUGA 3WPSA 3KUQA 1OW3A 2XS6A 2OSAA 1PBWA 2MBGA 2NGRB 3QISA 5C2JA 5JCPA 5IRCA 1F7CA 2EE4A 1XA6A 2QV2A 3FK2A 3MSXB 1GRNB 1TX4A 3W6RA 2OVJA 5HPYA 1RGPA 3CXLA 3WPQA 3BYIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EE5 A;  5JD0 A;  1AM4 A;  3EAP A;  5C5S A;  3IUG A;  3WPS A;  3KUQ A;  1OW3 A;  2XS6 A;  2OSA A;  1PBW A;  2MBG A;  2NGR B;  3QIS A;  5C2J A;  5JCP A;  5IRC A;  1F7C A;  2EE4 A;  1XA6 A;  2QV2 A;  3FK2 A;  3MSX B;  1GRN B;  1TX4 A;  3W6R A;  2OVJ A;  5HPY A;  1RGP A;  3CXL A;  3WPQ A;  3BYI A; 
#chains in the Genus database with same CATH topology
 2EE5 A;  5JD0 A;  1AM4 A;  3EAP A;  5C5S A;  3IUG A;  3WPS A;  3KUQ A;  1OW3 A;  2XS6 A;  2OSA A;  1PBW A;  2MBG A;  2NGR B;  3QIS A;  5C2J A;  5JCP A;  5IRC A;  1F7C A;  2EE4 A;  1XA6 A;  2QV2 A;  3FK2 A;  3MSX B;  1GRN B;  1TX4 A;  3W6R A;  2OVJ A;  5HPY A;  1RGP A;  3CXL A;  3WPQ A;  3BYI A; 
#chains in the Genus database with same CATH homology
 2EE5 A;  5JD0 A;  1AM4 A;  3EAP A;  5C5S A;  3IUG A;  3WPS A;  3KUQ A;  1OW3 A;  2XS6 A;  2OSA A;  1PBW A;  2MBG A;  2NGR B;  3QIS A;  5C2J A;  5JCP A;  5IRC A;  1F7C A;  2EE4 A;  1XA6 A;  2QV2 A;  3FK2 A;  3MSX B;  1GRN B;  1TX4 A;  3W6R A;  2OVJ A;  5HPY A;  1RGP A;  3CXL A;  3WPQ A;  3BYI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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