2XS6 | Genus

Total Genus 54

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	54
sequence length	186
structure length	166
Chain Sequence	LTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALGPAVRALGATFGPLLLRPSPDFPALLVEKLLQEHLEE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	The Structure and Catalytic Mechanism of Human Sphingomyelin Phosphodiesterase Like 3A - an Acid Sphingomyelinase Homolog with a Novel Nucleotide Hydrolase Activity. pubmed doi rcsb
molecule keywords	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
molecule tags	Transferase
source organism	Homo sapiens
total genus	54
structure length	166
sequence length	186
ec nomenclature
pdb deposition date	2010-09-24

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00620	RhoGAP	RhoGAP domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.555.10	Mainly Alpha	Orthogonal Bundle	Phosphatidylinositol 3-kinase; Chain A	Rho GTPase activation protein	2xs6A00

3QISA 5C5SA 5JD0A 3WPQA 1OW3A 5IRCA 5HPYA 2OSAA 2NGRB 2MBGA 5C2JA 3KUQA 2EE4A 3W6RA 3CXLA 3IUGA 3MSXB 3EAPA 1GRNB 1XA6A 1PBWA 1TX4A 5JCPA 3WPSA 2QV2A 3FK2A 3BYIA 1RGPA 2EE5A 2OVJA 2XS6A 1AM4A 1F7CA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 3QIS A;  5C5S A;  5JD0 A;  3WPQ A;  1OW3 A;  5IRC A;  5HPY A;  2OSA A;  2NGR B;  2MBG A;  5C2J A;  3KUQ A;  2EE4 A;  3W6R A;  3CXL A;  3IUG A;  3MSX B;  3EAP A;  1GRN B;  1XA6 A;  1PBW A;  1TX4 A;  5JCP A;  3WPS A;  2QV2 A;  3FK2 A;  3BYI A;  1RGP A;  2EE5 A;  2OVJ A;  2XS6 A;  1AM4 A;  1F7C A; 
#chains in the Genus database with same CATH topology
 3QIS A;  5C5S A;  5JD0 A;  3WPQ A;  1OW3 A;  5IRC A;  5HPY A;  2OSA A;  2NGR B;  2MBG A;  5C2J A;  3KUQ A;  2EE4 A;  3W6R A;  3CXL A;  3IUG A;  3MSX B;  3EAP A;  1GRN B;  1XA6 A;  1PBW A;  1TX4 A;  5JCP A;  3WPS A;  2QV2 A;  3FK2 A;  3BYI A;  1RGP A;  2EE5 A;  2OVJ A;  2XS6 A;  1AM4 A;  1F7C A; 
#chains in the Genus database with same CATH homology
 3QIS A;  5C5S A;  5JD0 A;  3WPQ A;  1OW3 A;  5IRC A;  5HPY A;  2OSA A;  2NGR B;  2MBG A;  5C2J A;  3KUQ A;  2EE4 A;  3W6R A;  3CXL A;  3IUG A;  3MSX B;  3EAP A;  1GRN B;  1XA6 A;  1PBW A;  1TX4 A;  5JCP A;  3WPS A;  2QV2 A;  3FK2 A;  3BYI A;  1RGP A;  2EE5 A;  2OVJ A;  2XS6 A;  1AM4 A;  1F7C A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2XS6A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations