3DETA

Structure of the e148a, y445a doubly ungated mutant of e.coli clc_ec1, cl-/h+ antiporter
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRAGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLASAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger
pubmed doi rcsb
molecule tags Membrane protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter clcA
total genus 178
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2008-06-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 3detA00
4KJQA 1OTUA 3ORGA 2EXWA 1KPKA 3DETA 2HTKA 2FEEA 4FG6A 4KKLA 2EZ0A 4KK8A 5HD8A 4KK6A 2HT3A 2HT4A 2HTLA 1OTSA 3Q17A 3NMOA 3EJZA 2H2SA 4KJWA 4MQXA 4KKAA 4KJPA 2H2PA 4ENEA 3ND0A 2FEDA 2R9HA 1OTTA 3EJYA 4LOUA 4KKCA 4KKBA 4FTPA 1KPLA 2HLFA 2EXYA 2FECA 4KK5A 2HT2A 4KK9A
chains in the Genus database with same CATH superfamily
4KJQA 1OTUA 3ORGA 2EXWA 1KPKA 3DETA 2HTKA 2FEEA 4FG6A 4KKLA 2EZ0A 4KK8A 5HD8A 4KK6A 2HT3A 2HT4A 2HTLA 1OTSA 3Q17A 3NMOA 3EJZA 2H2SA 4KJWA 4MQXA 4KKAA 4KJPA 2H2PA 4ENEA 3ND0A 2FEDA 2R9HA 1OTTA 3EJYA 4LOUA 4KKCA 4KKBA 4FTPA 1KPLA 2HLFA 2EXYA 2FECA 4KK5A 2HT2A 4KK9A
chains in the Genus database with same CATH topology
4KJQA 1OTUA 3ORGA 2EXWA 1KPKA 3DETA 2HTKA 2FEEA 4FG6A 4KKLA 2EZ0A 4KK8A 5HD8A 4KK6A 2HT3A 2HT4A 2HTLA 1OTSA 3Q17A 3NMOA 3EJZA 2H2SA 4KJWA 4MQXA 4KKAA 4KJPA 2H2PA 4ENEA 3ND0A 2FEDA 2R9HA 1OTTA 3EJYA 4LOUA 4KKCA 4KKBA 4FTPA 1KPLA 2HLFA 2EXYA 2FECA 4KK5A 2HT2A 4KK9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KJQ A;  1OTU A;  3ORG A;  2EXW A;  1KPK A;  3DET A;  2HTK A;  2FEE A;  4FG6 A;  4KKL A;  2EZ0 A;  4KK8 A;  5HD8 A;  4KK6 A;  2HT3 A;  2HT4 A;  2HTL A;  1OTS A;  3Q17 A;  3NMO A;  3EJZ A;  2H2S A;  4KJW A;  4MQX A;  4KKA A;  4KJP A;  2H2P A;  4ENE A;  3ND0 A;  2FED A;  2R9H A;  1OTT A;  3EJY A;  4LOU A;  4KKC A;  4KKB A;  4FTP A;  1KPL A;  2HLF A;  2EXY A;  2FEC A;  4KK5 A;  2HT2 A;  4KK9 A; 
#chains in the Genus database with same CATH topology
 4KJQ A;  1OTU A;  3ORG A;  2EXW A;  1KPK A;  3DET A;  2HTK A;  2FEE A;  4FG6 A;  4KKL A;  2EZ0 A;  4KK8 A;  5HD8 A;  4KK6 A;  2HT3 A;  2HT4 A;  2HTL A;  1OTS A;  3Q17 A;  3NMO A;  3EJZ A;  2H2S A;  4KJW A;  4MQX A;  4KKA A;  4KJP A;  2H2P A;  4ENE A;  3ND0 A;  2FED A;  2R9H A;  1OTT A;  3EJY A;  4LOU A;  4KKC A;  4KKB A;  4FTP A;  1KPL A;  2HLF A;  2EXY A;  2FEC A;  4KK5 A;  2HT2 A;  4KK9 A; 
#chains in the Genus database with same CATH homology
 4KJQ A;  1OTU A;  3ORG A;  2EXW A;  1KPK A;  3DET A;  2HTK A;  2FEE A;  4FG6 A;  4KKL A;  2EZ0 A;  4KK8 A;  5HD8 A;  4KK6 A;  2HT3 A;  2HT4 A;  2HTL A;  1OTS A;  3Q17 A;  3NMO A;  3EJZ A;  2H2S A;  4KJW A;  4MQX A;  4KKA A;  4KJP A;  2H2P A;  4ENE A;  3ND0 A;  2FED A;  2R9H A;  1OTT A;  3EJY A;  4LOU A;  4KKC A;  4KKB A;  4FTP A;  1KPL A;  2HLF A;  2EXY A;  2FEC A;  4KK5 A;  2HT2 A;  4KK9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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