4FQNA

Crystal structure of the ccm2 c-terminal harmonin homology domain (hhd)
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
95
structure length
95
Chain Sequence
GSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus.
pubmed doi rcsb
molecule keywords Malcavernin
molecule tags Protein binding
source organism Homo sapiens
total genus 39
structure length 95
sequence length 95
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-06-25
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1160.20 Mainly Alpha Up-down Bundle Paired amphipathic helix 2 (pah2 repeat) Paired amphipathic helix 2 (pah2 repeat) 4fqnA00
2KBRA 4FQNA 3K1RA 4Y5OA 4YKCA 5F3XA 4YL6A 2KBQA 4YKDA 2LSRA
chains in the Genus database with same CATH superfamily
2KBRA 2RMSA 1G1EB 2LSRA 1S5RB 2CZYA 4FQNA 3K1RA 2CR7A 2LD7B 2KBQA 1S5QB 1PD7A 4Y5OA 5F3XA 2RMRA 2L9SB 2F05A 4YKCA 4YL6A 4YKDA 1E91A
chains in the Genus database with same CATH topology
2KBRA 4FQNA 3K1RA 4Y5OA 4YKCA 5F3XA 4YL6A 2KBQA 4YKDA 2LSRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KBR A;  4FQN A;  3K1R A;  4Y5O A;  4YKC A;  5F3X A;  4YL6 A;  2KBQ A;  4YKD A;  2LSR A; 
#chains in the Genus database with same CATH topology
 2KBR A;  2RMS A;  1G1E B;  2LSR A;  1S5R B;  2CZY A;  4FQN A;  3K1R A;  2CR7 A;  2LD7 B;  2KBQ A;  1S5Q B;  1PD7 A;  4Y5O A;  5F3X A;  2RMR A;  2L9S B;  2F05 A;  4YKC A;  4YL6 A;  4YKD A;  1E91 A; 
#chains in the Genus database with same CATH homology
 2KBR A;  4FQN A;  3K1R A;  4Y5O A;  4YKC A;  5F3X A;  4YL6 A;  2KBQ A;  4YKD A;  2LSR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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