4FQNA

Crystal structure of the ccm2 c-terminal harmonin homology domain (hhd)
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
95
structure length
95
Chain Sequence
GSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Malcavernin
total genus 39
structure length 95
sequence length 95
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-06-25
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1160.20 Mainly Alpha Up-down Bundle Paired amphipathic helix 2 (pah2 repeat) Paired amphipathic helix 2 (pah2 repeat) 4fqnA00
2KBQA 4Y5OA 4YKDA 3K1RA 4YL6A 2LSRA 2KBRA 4YKCA 5F3XA 4FQNA
chains in the Genus database with same CATH superfamily
2KBQA 2F05A 3K1RA 2RMSA 1E91A 2L9SB 1PD7A 1S5QB 1G1EB 4FQNA 4Y5OA 4YL6A 2KBRA 4YKCA 5F3XA 4YKDA 2CZYA 2LSRA 2LD7B 2RMRA 1S5RB 2CR7A
chains in the Genus database with same CATH topology
2KBQA 4Y5OA 4YKDA 3K1RA 4YL6A 2LSRA 2KBRA 4YKCA 5F3XA 4FQNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KBQ A;  4Y5O A;  4YKD A;  3K1R A;  4YL6 A;  2LSR A;  2KBR A;  4YKC A;  5F3X A;  4FQN A; 
#chains in the Genus database with same CATH topology
 2KBQ A;  2F05 A;  3K1R A;  2RMS A;  1E91 A;  2L9S B;  1PD7 A;  1S5Q B;  1G1E B;  4FQN A;  4Y5O A;  4YL6 A;  2KBR A;  4YKC A;  5F3X A;  4YKD A;  2CZY A;  2LSR A;  2LD7 B;  2RMR A;  1S5R B;  2CR7 A; 
#chains in the Genus database with same CATH homology
 2KBQ A;  4Y5O A;  4YKD A;  3K1R A;  4YL6 A;  2LSR A;  2KBR A;  4YKC A;  5F3X A;  4FQN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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