4KJWA

Structure of the clc-ec1 deltanc construct in 100mm fluoride and 20mm bromide
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
pubmed doi rcsb
molecule tags Transport protein, membrane protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter ClcA
total genus 178
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 4kjwA00
2EZ0A 2FEDA 2H2PA 1KPLA 4LOUA 1OTUA 4FTPA 3ND0A 2HTKA 1OTSA 2H2SA 1OTTA 5HD8A 4KK5A 2EXYA 2EXWA 4KJPA 3EJZA 4ENEA 4KKAA 2HT2A 2HLFA 1KPKA 4FG6A 2HT3A 4MQXA 4KK8A 4KKBA 4KKCA 3ORGA 2FEEA 3Q17A 2HTLA 4KK9A 3DETA 4KJQA 2R9HA 3NMOA 4KK6A 4KKLA 2FECA 3EJYA 4KJWA 2HT4A
chains in the Genus database with same CATH superfamily
2EZ0A 2FEDA 2H2PA 1KPLA 4LOUA 1OTUA 4FTPA 3ND0A 2HTKA 1OTSA 2H2SA 1OTTA 5HD8A 4KK5A 2EXYA 2EXWA 4KJPA 3EJZA 4ENEA 4KKAA 2HT2A 2HLFA 1KPKA 4FG6A 2HT3A 4MQXA 4KK8A 4KKBA 4KKCA 3ORGA 2FEEA 3Q17A 2HTLA 4KK9A 3DETA 4KJQA 2R9HA 3NMOA 4KK6A 4KKLA 2FECA 3EJYA 4KJWA 2HT4A
chains in the Genus database with same CATH topology
2EZ0A 2FEDA 2H2PA 1KPLA 4LOUA 1OTUA 4FTPA 3ND0A 2HTKA 1OTSA 2H2SA 1OTTA 5HD8A 4KK5A 2EXYA 2EXWA 4KJPA 3EJZA 4ENEA 4KKAA 2HT2A 2HLFA 1KPKA 4FG6A 2HT3A 4MQXA 4KK8A 4KKBA 4KKCA 3ORGA 2FEEA 3Q17A 2HTLA 4KK9A 3DETA 4KJQA 2R9HA 3NMOA 4KK6A 4KKLA 2FECA 3EJYA 4KJWA 2HT4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EZ0 A;  2FED A;  2H2P A;  1KPL A;  4LOU A;  1OTU A;  4FTP A;  3ND0 A;  2HTK A;  1OTS A;  2H2S A;  1OTT A;  5HD8 A;  4KK5 A;  2EXY A;  2EXW A;  4KJP A;  3EJZ A;  4ENE A;  4KKA A;  2HT2 A;  2HLF A;  1KPK A;  4FG6 A;  2HT3 A;  4MQX A;  4KK8 A;  4KKB A;  4KKC A;  3ORG A;  2FEE A;  3Q17 A;  2HTL A;  4KK9 A;  3DET A;  4KJQ A;  2R9H A;  3NMO A;  4KK6 A;  4KKL A;  2FEC A;  3EJY A;  4KJW A;  2HT4 A; 
#chains in the Genus database with same CATH topology
 2EZ0 A;  2FED A;  2H2P A;  1KPL A;  4LOU A;  1OTU A;  4FTP A;  3ND0 A;  2HTK A;  1OTS A;  2H2S A;  1OTT A;  5HD8 A;  4KK5 A;  2EXY A;  2EXW A;  4KJP A;  3EJZ A;  4ENE A;  4KKA A;  2HT2 A;  2HLF A;  1KPK A;  4FG6 A;  2HT3 A;  4MQX A;  4KK8 A;  4KKB A;  4KKC A;  3ORG A;  2FEE A;  3Q17 A;  2HTL A;  4KK9 A;  3DET A;  4KJQ A;  2R9H A;  3NMO A;  4KK6 A;  4KKL A;  2FEC A;  3EJY A;  4KJW A;  2HT4 A; 
#chains in the Genus database with same CATH homology
 2EZ0 A;  2FED A;  2H2P A;  1KPL A;  4LOU A;  1OTU A;  4FTP A;  3ND0 A;  2HTK A;  1OTS A;  2H2S A;  1OTT A;  5HD8 A;  4KK5 A;  2EXY A;  2EXW A;  4KJP A;  3EJZ A;  4ENE A;  4KKA A;  2HT2 A;  2HLF A;  1KPK A;  4FG6 A;  2HT3 A;  4MQX A;  4KK8 A;  4KKB A;  4KKC A;  3ORG A;  2FEE A;  3Q17 A;  2HTL A;  4KK9 A;  3DET A;  4KJQ A;  2R9H A;  3NMO A;  4KK6 A;  4KKL A;  2FEC A;  3EJY A;  4KJW A;  2HT4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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