4KK8A

Structure of the e148q mutant of clc-ec1 deltanc construct in 100mm fluoride
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
sequence length
442
structure length
442
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRQGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
pubmed doi rcsb
molecule tags Transport protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter ClcA
total genus 176
structure length 442
sequence length 442
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 4kk8A00
2HT3A 3NMOA 3EJZA 4LOUA 2FEEA 4FG6A 4KKLA 1KPLA 5HD8A 3ORGA 2HLFA 2EZ0A 1OTTA 2FEDA 4KJQA 2EXWA 3Q17A 2HT4A 4KKAA 2R9HA 1OTUA 4KK8A 4KKBA 2HTLA 4MQXA 4KK9A 4KK5A 4KJPA 1KPKA 3ND0A 2HTKA 2FECA 3DETA 4KJWA 2H2SA 3EJYA 4ENEA 1OTSA 2H2PA 4KKCA 4KK6A 4FTPA 2HT2A 2EXYA
chains in the Genus database with same CATH superfamily
2HT3A 3NMOA 3EJZA 4LOUA 2FEEA 4FG6A 4KKLA 1KPLA 5HD8A 3ORGA 2HLFA 2EZ0A 1OTTA 2FEDA 4KJQA 2EXWA 3Q17A 2HT4A 4KKAA 2R9HA 1OTUA 4KK8A 4KKBA 2HTLA 4MQXA 4KK9A 4KK5A 4KJPA 1KPKA 3ND0A 2HTKA 2FECA 3DETA 4KJWA 2H2SA 3EJYA 4ENEA 1OTSA 2H2PA 4KKCA 4KK6A 4FTPA 2HT2A 2EXYA
chains in the Genus database with same CATH topology
2HT3A 3NMOA 3EJZA 4LOUA 2FEEA 4FG6A 4KKLA 1KPLA 5HD8A 3ORGA 2HLFA 2EZ0A 1OTTA 2FEDA 4KJQA 2EXWA 3Q17A 2HT4A 4KKAA 2R9HA 1OTUA 4KK8A 4KKBA 2HTLA 4MQXA 4KK9A 4KK5A 4KJPA 1KPKA 3ND0A 2HTKA 2FECA 3DETA 4KJWA 2H2SA 3EJYA 4ENEA 1OTSA 2H2PA 4KKCA 4KK6A 4FTPA 2HT2A 2EXYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HT3 A;  3NMO A;  3EJZ A;  4LOU A;  2FEE A;  4FG6 A;  4KKL A;  1KPL A;  5HD8 A;  3ORG A;  2HLF A;  2EZ0 A;  1OTT A;  2FED A;  4KJQ A;  2EXW A;  3Q17 A;  2HT4 A;  4KKA A;  2R9H A;  1OTU A;  4KK8 A;  4KKB A;  2HTL A;  4MQX A;  4KK9 A;  4KK5 A;  4KJP A;  1KPK A;  3ND0 A;  2HTK A;  2FEC A;  3DET A;  4KJW A;  2H2S A;  3EJY A;  4ENE A;  1OTS A;  2H2P A;  4KKC A;  4KK6 A;  4FTP A;  2HT2 A;  2EXY A; 
#chains in the Genus database with same CATH topology
 2HT3 A;  3NMO A;  3EJZ A;  4LOU A;  2FEE A;  4FG6 A;  4KKL A;  1KPL A;  5HD8 A;  3ORG A;  2HLF A;  2EZ0 A;  1OTT A;  2FED A;  4KJQ A;  2EXW A;  3Q17 A;  2HT4 A;  4KKA A;  2R9H A;  1OTU A;  4KK8 A;  4KKB A;  2HTL A;  4MQX A;  4KK9 A;  4KK5 A;  4KJP A;  1KPK A;  3ND0 A;  2HTK A;  2FEC A;  3DET A;  4KJW A;  2H2S A;  3EJY A;  4ENE A;  1OTS A;  2H2P A;  4KKC A;  4KK6 A;  4FTP A;  2HT2 A;  2EXY A; 
#chains in the Genus database with same CATH homology
 2HT3 A;  3NMO A;  3EJZ A;  4LOU A;  2FEE A;  4FG6 A;  4KKL A;  1KPL A;  5HD8 A;  3ORG A;  2HLF A;  2EZ0 A;  1OTT A;  2FED A;  4KJQ A;  2EXW A;  3Q17 A;  2HT4 A;  4KKA A;  2R9H A;  1OTU A;  4KK8 A;  4KKB A;  2HTL A;  4MQX A;  4KK9 A;  4KK5 A;  4KJP A;  1KPK A;  3ND0 A;  2HTK A;  2FEC A;  3DET A;  4KJW A;  2H2S A;  3EJY A;  4ENE A;  1OTS A;  2H2P A;  4KKC A;  4KK6 A;  4FTP A;  2HT2 A;  2EXY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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