4KK8A

Structure of the e148q mutant of clc-ec1 deltanc construct in 100mm fluoride
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
sequence length
442
structure length
442
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRQGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
pubmed doi rcsb
molecule keywords H(+)/Cl(-) exchange transporter ClcA
molecule tags Transport protein
source organism Escherichia coli
total genus 176
structure length 442
sequence length 442
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 4kk8A00
2HLFA 3EJZA 4KKLA 4KJPA 4KJQA 1KPLA 2EXWA 3ND0A 4KK6A 2EXYA 4LOUA 3NMOA 3Q17A 4FTPA 2FEEA 4KK9A 4KK5A 4KK8A 4KKAA 1OTUA 2FEDA 2HT2A 4KKCA 2FECA 2EZ0A 5HD8A 2HT4A 1KPKA 2HTLA 3DETA 4ENEA 4MQXA 2HTKA 1OTTA 2H2PA 3EJYA 2R9HA 1OTSA 3ORGA 4KKBA 2HT3A 4FG6A 4KJWA 2H2SA
chains in the Genus database with same CATH superfamily
2HLFA 3EJZA 4KKLA 4KJPA 4KJQA 1KPLA 2EXWA 3ND0A 4KK6A 2EXYA 4LOUA 3NMOA 3Q17A 4FTPA 2FEEA 4KK9A 4KK5A 4KK8A 4KKAA 1OTUA 2FEDA 2HT2A 4KKCA 2FECA 2EZ0A 5HD8A 2HT4A 1KPKA 2HTLA 3DETA 4ENEA 4MQXA 2HTKA 1OTTA 2H2PA 3EJYA 2R9HA 1OTSA 3ORGA 4KKBA 2HT3A 4FG6A 4KJWA 2H2SA
chains in the Genus database with same CATH topology
2HLFA 3EJZA 4KKLA 4KJPA 4KJQA 1KPLA 2EXWA 3ND0A 4KK6A 2EXYA 4LOUA 3NMOA 3Q17A 4FTPA 2FEEA 4KK9A 4KK5A 4KK8A 4KKAA 1OTUA 2FEDA 2HT2A 4KKCA 2FECA 2EZ0A 5HD8A 2HT4A 1KPKA 2HTLA 3DETA 4ENEA 4MQXA 2HTKA 1OTTA 2H2PA 3EJYA 2R9HA 1OTSA 3ORGA 4KKBA 2HT3A 4FG6A 4KJWA 2H2SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HLF A;  3EJZ A;  4KKL A;  4KJP A;  4KJQ A;  1KPL A;  2EXW A;  3ND0 A;  4KK6 A;  2EXY A;  4LOU A;  3NMO A;  3Q17 A;  4FTP A;  2FEE A;  4KK9 A;  4KK5 A;  4KK8 A;  4KKA A;  1OTU A;  2FED A;  2HT2 A;  4KKC A;  2FEC A;  2EZ0 A;  5HD8 A;  2HT4 A;  1KPK A;  2HTL A;  3DET A;  4ENE A;  4MQX A;  2HTK A;  1OTT A;  2H2P A;  3EJY A;  2R9H A;  1OTS A;  3ORG A;  4KKB A;  2HT3 A;  4FG6 A;  4KJW A;  2H2S A; 
#chains in the Genus database with same CATH topology
 2HLF A;  3EJZ A;  4KKL A;  4KJP A;  4KJQ A;  1KPL A;  2EXW A;  3ND0 A;  4KK6 A;  2EXY A;  4LOU A;  3NMO A;  3Q17 A;  4FTP A;  2FEE A;  4KK9 A;  4KK5 A;  4KK8 A;  4KKA A;  1OTU A;  2FED A;  2HT2 A;  4KKC A;  2FEC A;  2EZ0 A;  5HD8 A;  2HT4 A;  1KPK A;  2HTL A;  3DET A;  4ENE A;  4MQX A;  2HTK A;  1OTT A;  2H2P A;  3EJY A;  2R9H A;  1OTS A;  3ORG A;  4KKB A;  2HT3 A;  4FG6 A;  4KJW A;  2H2S A; 
#chains in the Genus database with same CATH homology
 2HLF A;  3EJZ A;  4KKL A;  4KJP A;  4KJQ A;  1KPL A;  2EXW A;  3ND0 A;  4KK6 A;  2EXY A;  4LOU A;  3NMO A;  3Q17 A;  4FTP A;  2FEE A;  4KK9 A;  4KK5 A;  4KK8 A;  4KKA A;  1OTU A;  2FED A;  2HT2 A;  4KKC A;  2FEC A;  2EZ0 A;  5HD8 A;  2HT4 A;  1KPK A;  2HTL A;  3DET A;  4ENE A;  4MQX A;  2HTK A;  1OTT A;  2H2P A;  3EJY A;  2R9H A;  1OTS A;  3ORG A;  4KKB A;  2HT3 A;  4FG6 A;  4KJW A;  2H2S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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