4KKAA

Structure of the e148a mutant of clc-ec1 deltanc construct in 100mm fluoride and 20mm bromide
Total Genus 174
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
443
structure length
443
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRAGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
pubmed doi rcsb
molecule tags Transport protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter ClcA
total genus 174
structure length 443
sequence length 443
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 4kkaA00
5HD8A 2HT2A 4KJPA 2HLFA 4FTPA 4LOUA 4MQXA 3Q17A 2FEDA 2FECA 4ENEA 1OTSA 3ND0A 2H2PA 4KK6A 2HTKA 1OTUA 2FEEA 4KK9A 3EJZA 3DETA 4KK8A 3EJYA 4KK5A 2EXYA 4KJQA 2HTLA 4KKAA 4KJWA 2R9HA 3ORGA 4FG6A 1KPLA 4KKCA 2H2SA 2EXWA 2HT3A 2HT4A 4KKBA 2EZ0A 1OTTA 3NMOA 4KKLA 1KPKA
chains in the Genus database with same CATH superfamily
5HD8A 2HT2A 4KJPA 2HLFA 4FTPA 4LOUA 4MQXA 3Q17A 2FEDA 2FECA 4ENEA 1OTSA 3ND0A 2H2PA 4KK6A 2HTKA 1OTUA 2FEEA 4KK9A 3EJZA 3DETA 4KK8A 3EJYA 4KK5A 2EXYA 4KJQA 2HTLA 4KKAA 4KJWA 2R9HA 3ORGA 4FG6A 1KPLA 4KKCA 2H2SA 2EXWA 2HT3A 2HT4A 4KKBA 2EZ0A 1OTTA 3NMOA 4KKLA 1KPKA
chains in the Genus database with same CATH topology
5HD8A 2HT2A 4KJPA 2HLFA 4FTPA 4LOUA 4MQXA 3Q17A 2FEDA 2FECA 4ENEA 1OTSA 3ND0A 2H2PA 4KK6A 2HTKA 1OTUA 2FEEA 4KK9A 3EJZA 3DETA 4KK8A 3EJYA 4KK5A 2EXYA 4KJQA 2HTLA 4KKAA 4KJWA 2R9HA 3ORGA 4FG6A 1KPLA 4KKCA 2H2SA 2EXWA 2HT3A 2HT4A 4KKBA 2EZ0A 1OTTA 3NMOA 4KKLA 1KPKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HD8 A;  2HT2 A;  4KJP A;  2HLF A;  4FTP A;  4LOU A;  4MQX A;  3Q17 A;  2FED A;  2FEC A;  4ENE A;  1OTS A;  3ND0 A;  2H2P A;  4KK6 A;  2HTK A;  1OTU A;  2FEE A;  4KK9 A;  3EJZ A;  3DET A;  4KK8 A;  3EJY A;  4KK5 A;  2EXY A;  4KJQ A;  2HTL A;  4KKA A;  4KJW A;  2R9H A;  3ORG A;  4FG6 A;  1KPL A;  4KKC A;  2H2S A;  2EXW A;  2HT3 A;  2HT4 A;  4KKB A;  2EZ0 A;  1OTT A;  3NMO A;  4KKL A;  1KPK A; 
#chains in the Genus database with same CATH topology
 5HD8 A;  2HT2 A;  4KJP A;  2HLF A;  4FTP A;  4LOU A;  4MQX A;  3Q17 A;  2FED A;  2FEC A;  4ENE A;  1OTS A;  3ND0 A;  2H2P A;  4KK6 A;  2HTK A;  1OTU A;  2FEE A;  4KK9 A;  3EJZ A;  3DET A;  4KK8 A;  3EJY A;  4KK5 A;  2EXY A;  4KJQ A;  2HTL A;  4KKA A;  4KJW A;  2R9H A;  3ORG A;  4FG6 A;  1KPL A;  4KKC A;  2H2S A;  2EXW A;  2HT3 A;  2HT4 A;  4KKB A;  2EZ0 A;  1OTT A;  3NMO A;  4KKL A;  1KPK A; 
#chains in the Genus database with same CATH homology
 5HD8 A;  2HT2 A;  4KJP A;  2HLF A;  4FTP A;  4LOU A;  4MQX A;  3Q17 A;  2FED A;  2FEC A;  4ENE A;  1OTS A;  3ND0 A;  2H2P A;  4KK6 A;  2HTK A;  1OTU A;  2FEE A;  4KK9 A;  3EJZ A;  3DET A;  4KK8 A;  3EJY A;  4KK5 A;  2EXY A;  4KJQ A;  2HTL A;  4KKA A;  4KJW A;  2R9H A;  3ORG A;  4FG6 A;  1KPL A;  4KKC A;  2H2S A;  2EXW A;  2HT3 A;  2HT4 A;  4KKB A;  2EZ0 A;  1OTT A;  3NMO A;  4KKL A;  1KPK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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