4KKLA

Structure of the e148a mutant of clc-ec1 delta nc construct in 100mm fluoride
Total Genus 177
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRAGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
pubmed doi rcsb
molecule tags Tranport protein, membrane protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter ClcA
total genus 177
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 4kklA00
2FECA 4FG6A 2HLFA 4FTPA 4KK8A 3DETA 1KPLA 3EJZA 4KKLA 2EXWA 4KK9A 2HT2A 2FEDA 2HTKA 2EZ0A 4KK5A 2HT4A 4ENEA 4KKBA 3Q17A 4KJQA 1OTTA 4LOUA 2FEEA 3NMOA 2R9HA 4KKCA 2EXYA 2HT3A 3ORGA 4KJPA 3EJYA 4KK6A 1OTSA 4MQXA 5HD8A 2H2SA 1OTUA 3ND0A 4KKAA 2H2PA 1KPKA 4KJWA 2HTLA
chains in the Genus database with same CATH superfamily
2FECA 4FG6A 2HLFA 4FTPA 4KK8A 3DETA 1KPLA 3EJZA 4KKLA 2EXWA 4KK9A 2HT2A 2FEDA 2HTKA 2EZ0A 4KK5A 2HT4A 4ENEA 4KKBA 3Q17A 4KJQA 1OTTA 4LOUA 2FEEA 3NMOA 2R9HA 4KKCA 2EXYA 2HT3A 3ORGA 4KJPA 3EJYA 4KK6A 1OTSA 4MQXA 5HD8A 2H2SA 1OTUA 3ND0A 4KKAA 2H2PA 1KPKA 4KJWA 2HTLA
chains in the Genus database with same CATH topology
2FECA 4FG6A 2HLFA 4FTPA 4KK8A 3DETA 1KPLA 3EJZA 4KKLA 2EXWA 4KK9A 2HT2A 2FEDA 2HTKA 2EZ0A 4KK5A 2HT4A 4ENEA 4KKBA 3Q17A 4KJQA 1OTTA 4LOUA 2FEEA 3NMOA 2R9HA 4KKCA 2EXYA 2HT3A 3ORGA 4KJPA 3EJYA 4KK6A 1OTSA 4MQXA 5HD8A 2H2SA 1OTUA 3ND0A 4KKAA 2H2PA 1KPKA 4KJWA 2HTLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FEC A;  4FG6 A;  2HLF A;  4FTP A;  4KK8 A;  3DET A;  1KPL A;  3EJZ A;  4KKL A;  2EXW A;  4KK9 A;  2HT2 A;  2FED A;  2HTK A;  2EZ0 A;  4KK5 A;  2HT4 A;  4ENE A;  4KKB A;  3Q17 A;  4KJQ A;  1OTT A;  4LOU A;  2FEE A;  3NMO A;  2R9H A;  4KKC A;  2EXY A;  2HT3 A;  3ORG A;  4KJP A;  3EJY A;  4KK6 A;  1OTS A;  4MQX A;  5HD8 A;  2H2S A;  1OTU A;  3ND0 A;  4KKA A;  2H2P A;  1KPK A;  4KJW A;  2HTL A; 
#chains in the Genus database with same CATH topology
 2FEC A;  4FG6 A;  2HLF A;  4FTP A;  4KK8 A;  3DET A;  1KPL A;  3EJZ A;  4KKL A;  2EXW A;  4KK9 A;  2HT2 A;  2FED A;  2HTK A;  2EZ0 A;  4KK5 A;  2HT4 A;  4ENE A;  4KKB A;  3Q17 A;  4KJQ A;  1OTT A;  4LOU A;  2FEE A;  3NMO A;  2R9H A;  4KKC A;  2EXY A;  2HT3 A;  3ORG A;  4KJP A;  3EJY A;  4KK6 A;  1OTS A;  4MQX A;  5HD8 A;  2H2S A;  1OTU A;  3ND0 A;  4KKA A;  2H2P A;  1KPK A;  4KJW A;  2HTL A; 
#chains in the Genus database with same CATH homology
 2FEC A;  4FG6 A;  2HLF A;  4FTP A;  4KK8 A;  3DET A;  1KPL A;  3EJZ A;  4KKL A;  2EXW A;  4KK9 A;  2HT2 A;  2FED A;  2HTK A;  2EZ0 A;  4KK5 A;  2HT4 A;  4ENE A;  4KKB A;  3Q17 A;  4KJQ A;  1OTT A;  4LOU A;  2FEE A;  3NMO A;  2R9H A;  4KKC A;  2EXY A;  2HT3 A;  3ORG A;  4KJP A;  3EJY A;  4KK6 A;  1OTS A;  4MQX A;  5HD8 A;  2H2S A;  1OTU A;  3ND0 A;  4KKA A;  2H2P A;  1KPK A;  4KJW A;  2HTL A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...