4KKLA

Structure of the e148a mutant of clc-ec1 delta nc construct in 100mm fluoride
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRAGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
pubmed doi rcsb
molecule keywords H(+)/Cl(-) exchange transporter ClcA
molecule tags Tranport protein, membrane protein
source organism Escherichia coli
total genus 177
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 4kklA00
4KJWA 4KKLA 2EZ0A 3DETA 1KPLA 3ORGA 3ND0A 4LOUA 4KK9A 2FECA 2HT4A 4KK6A 4ENEA 4KKAA 1OTUA 1OTSA 4KKCA 2HLFA 4FG6A 2HT3A 4KJQA 2EXYA 2R9HA 2H2PA 4KJPA 3NMOA 2FEDA 2EXWA 2HTKA 4KK8A 3EJYA 5HD8A 3Q17A 4KK5A 1OTTA 4FTPA 3EJZA 4KKBA 4MQXA 2HT2A 1KPKA 2HTLA 2H2SA 2FEEA
chains in the Genus database with same CATH superfamily
4KJWA 4KKLA 2EZ0A 3DETA 1KPLA 3ORGA 3ND0A 4LOUA 4KK9A 2FECA 2HT4A 4KK6A 4ENEA 4KKAA 1OTUA 1OTSA 4KKCA 2HLFA 4FG6A 2HT3A 4KJQA 2EXYA 2R9HA 2H2PA 4KJPA 3NMOA 2FEDA 2EXWA 2HTKA 4KK8A 3EJYA 5HD8A 3Q17A 4KK5A 1OTTA 4FTPA 3EJZA 4KKBA 4MQXA 2HT2A 1KPKA 2HTLA 2H2SA 2FEEA
chains in the Genus database with same CATH topology
4KJWA 4KKLA 2EZ0A 3DETA 1KPLA 3ORGA 3ND0A 4LOUA 4KK9A 2FECA 2HT4A 4KK6A 4ENEA 4KKAA 1OTUA 1OTSA 4KKCA 2HLFA 4FG6A 2HT3A 4KJQA 2EXYA 2R9HA 2H2PA 4KJPA 3NMOA 2FEDA 2EXWA 2HTKA 4KK8A 3EJYA 5HD8A 3Q17A 4KK5A 1OTTA 4FTPA 3EJZA 4KKBA 4MQXA 2HT2A 1KPKA 2HTLA 2H2SA 2FEEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KJW A;  4KKL A;  2EZ0 A;  3DET A;  1KPL A;  3ORG A;  3ND0 A;  4LOU A;  4KK9 A;  2FEC A;  2HT4 A;  4KK6 A;  4ENE A;  4KKA A;  1OTU A;  1OTS A;  4KKC A;  2HLF A;  4FG6 A;  2HT3 A;  4KJQ A;  2EXY A;  2R9H A;  2H2P A;  4KJP A;  3NMO A;  2FED A;  2EXW A;  2HTK A;  4KK8 A;  3EJY A;  5HD8 A;  3Q17 A;  4KK5 A;  1OTT A;  4FTP A;  3EJZ A;  4KKB A;  4MQX A;  2HT2 A;  1KPK A;  2HTL A;  2H2S A;  2FEE A; 
#chains in the Genus database with same CATH topology
 4KJW A;  4KKL A;  2EZ0 A;  3DET A;  1KPL A;  3ORG A;  3ND0 A;  4LOU A;  4KK9 A;  2FEC A;  2HT4 A;  4KK6 A;  4ENE A;  4KKA A;  1OTU A;  1OTS A;  4KKC A;  2HLF A;  4FG6 A;  2HT3 A;  4KJQ A;  2EXY A;  2R9H A;  2H2P A;  4KJP A;  3NMO A;  2FED A;  2EXW A;  2HTK A;  4KK8 A;  3EJY A;  5HD8 A;  3Q17 A;  4KK5 A;  1OTT A;  4FTP A;  3EJZ A;  4KKB A;  4MQX A;  2HT2 A;  1KPK A;  2HTL A;  2H2S A;  2FEE A; 
#chains in the Genus database with same CATH homology
 4KJW A;  4KKL A;  2EZ0 A;  3DET A;  1KPL A;  3ORG A;  3ND0 A;  4LOU A;  4KK9 A;  2FEC A;  2HT4 A;  4KK6 A;  4ENE A;  4KKA A;  1OTU A;  1OTS A;  4KKC A;  2HLF A;  4FG6 A;  2HT3 A;  4KJQ A;  2EXY A;  2R9H A;  2H2P A;  4KJP A;  3NMO A;  2FED A;  2EXW A;  2HTK A;  4KK8 A;  3EJY A;  5HD8 A;  3Q17 A;  4KK5 A;  1OTT A;  4FTP A;  3EJZ A;  4KKB A;  4MQX A;  2HT2 A;  1KPK A;  2HTL A;  2H2S A;  2FEE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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