5HD8A

Crystal structure of disulfide cross-linked d417c clc-ec1
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
442
structure length
433
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTCNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational change in CLC transporters: beyond the rotation of Gluex
rcsb
molecule tags Transport protein
source organism Escherichia coli
molecule keywords H(+)/Cl(-) exchange transporter ClcA
total genus 173
structure length 433
sequence length 442
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 5hd8A00
2H2SA 3DETA 2HTKA 3ND0A 4KKCA 2FEDA 2EXWA 3NMOA 2EXYA 2FEEA 4KJPA 3Q17A 2H2PA 4FG6A 2HT4A 4KK6A 4KK5A 4KKAA 4LOUA 1OTTA 1KPLA 3EJYA 3EJZA 5HD8A 2FECA 2R9HA 4KJQA 4FTPA 1KPKA 2HLFA 3ORGA 2HTLA 2HT3A 1OTSA 1OTUA 2HT2A 4KJWA 4MQXA 4KKLA 4KK9A 4ENEA 2EZ0A 4KKBA 4KK8A
chains in the Genus database with same CATH superfamily
2H2SA 3DETA 2HTKA 3ND0A 4KKCA 2FEDA 2EXWA 3NMOA 2EXYA 2FEEA 4KJPA 3Q17A 2H2PA 4FG6A 2HT4A 4KK6A 4KK5A 4KKAA 4LOUA 1OTTA 1KPLA 3EJYA 3EJZA 5HD8A 2FECA 2R9HA 4KJQA 4FTPA 1KPKA 2HLFA 3ORGA 2HTLA 2HT3A 1OTSA 1OTUA 2HT2A 4KJWA 4MQXA 4KKLA 4KK9A 4ENEA 2EZ0A 4KKBA 4KK8A
chains in the Genus database with same CATH topology
2H2SA 3DETA 2HTKA 3ND0A 4KKCA 2FEDA 2EXWA 3NMOA 2EXYA 2FEEA 4KJPA 3Q17A 2H2PA 4FG6A 2HT4A 4KK6A 4KK5A 4KKAA 4LOUA 1OTTA 1KPLA 3EJYA 3EJZA 5HD8A 2FECA 2R9HA 4KJQA 4FTPA 1KPKA 2HLFA 3ORGA 2HTLA 2HT3A 1OTSA 1OTUA 2HT2A 4KJWA 4MQXA 4KKLA 4KK9A 4ENEA 2EZ0A 4KKBA 4KK8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H2S A;  3DET A;  2HTK A;  3ND0 A;  4KKC A;  2FED A;  2EXW A;  3NMO A;  2EXY A;  2FEE A;  4KJP A;  3Q17 A;  2H2P A;  4FG6 A;  2HT4 A;  4KK6 A;  4KK5 A;  4KKA A;  4LOU A;  1OTT A;  1KPL A;  3EJY A;  3EJZ A;  5HD8 A;  2FEC A;  2R9H A;  4KJQ A;  4FTP A;  1KPK A;  2HLF A;  3ORG A;  2HTL A;  2HT3 A;  1OTS A;  1OTU A;  2HT2 A;  4KJW A;  4MQX A;  4KKL A;  4KK9 A;  4ENE A;  2EZ0 A;  4KKB A;  4KK8 A; 
#chains in the Genus database with same CATH topology
 2H2S A;  3DET A;  2HTK A;  3ND0 A;  4KKC A;  2FED A;  2EXW A;  3NMO A;  2EXY A;  2FEE A;  4KJP A;  3Q17 A;  2H2P A;  4FG6 A;  2HT4 A;  4KK6 A;  4KK5 A;  4KKA A;  4LOU A;  1OTT A;  1KPL A;  3EJY A;  3EJZ A;  5HD8 A;  2FEC A;  2R9H A;  4KJQ A;  4FTP A;  1KPK A;  2HLF A;  3ORG A;  2HTL A;  2HT3 A;  1OTS A;  1OTU A;  2HT2 A;  4KJW A;  4MQX A;  4KKL A;  4KK9 A;  4ENE A;  2EZ0 A;  4KKB A;  4KK8 A; 
#chains in the Genus database with same CATH homology
 2H2S A;  3DET A;  2HTK A;  3ND0 A;  4KKC A;  2FED A;  2EXW A;  3NMO A;  2EXY A;  2FEE A;  4KJP A;  3Q17 A;  2H2P A;  4FG6 A;  2HT4 A;  4KK6 A;  4KK5 A;  4KKA A;  4LOU A;  1OTT A;  1KPL A;  3EJY A;  3EJZ A;  5HD8 A;  2FEC A;  2R9H A;  4KJQ A;  4FTP A;  1KPK A;  2HLF A;  3ORG A;  2HTL A;  2HT3 A;  1OTS A;  1OTU A;  2HT2 A;  4KJW A;  4MQX A;  4KKL A;  4KK9 A;  4ENE A;  2EZ0 A;  4KKB A;  4KK8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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