2DSPI

Structural basis for the inhibition of insulin-like growth factors by igf binding proteins
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
67
structure length
57
Chain Sequence
PETLCGAELVDALQFVCGDRGFYFNKPTQTGIVDECCFRSCDLRRLEMYCAPLKPAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding/hormone/growth factor
molecule keywords Insulin-like growth factor-binding protein 4
publication title Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
pubmed doi rcsb
source organism Homo sapiens
total genus 12
structure length 57
sequence length 67
ec nomenclature
pdb deposition date 2006-07-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2dspI00
2JZQA 1IMXA 1GZYB 5L3LA 2DSPI 2DSRI 2KQPA 5L3NA 1B9GA 1GZZB 5L3MA 3GF1A 3LRIA 1WQJI 2L29B 2GF1A 1IGLA 1ZEIA 2LWZA 6INSE 1H02B 1EFEA 1TGRA 3KR3D 1H59A 1PMXA 2DSQC 4XSSB 2KJIA 1BQTA 1SJUA 1GZRB
chains in the Genus database with same CATH superfamily
2JZQA 1IMXA 1GZYB 5L3LA 3F2DA 2DSPI 2DSRI 3F2BA 2KQPA 5L3NA 1B9GA 1GZZB 5L3MA 3GF1A 3LRIA 1WQJI 2L29B 2GF1A 1IGLA 1ZEIA 2LWZA 6INSE 3F2CA 1H02B 1EFEA 1TGRA 3KR3D 1H59A 1PMXA 2DSQC 2L14B 4XSSB 2KJIA 1BQTA 1SJUA 1GZRB
chains in the Genus database with same CATH topology
2JZQA 1IMXA 1GZYB 5L3LA 2DSPI 2DSRI 2KQPA 5L3NA 1B9GA 1GZZB 5L3MA 3GF1A 3LRIA 1WQJI 2L29B 2GF1A 1IGLA 1ZEIA 2LWZA 6INSE 1H02B 1EFEA 1TGRA 3KR3D 1H59A 1PMXA 2DSQC 4XSSB 2KJIA 1BQTA 1SJUA 1GZRB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JZQ A;  1IMX A;  1GZY B;  5L3L A;  2DSP I;  2DSR I;  2KQP A;  5L3N A;  1B9G A;  1GZZ B;  5L3M A;  3GF1 A;  3LRI A;  1WQJ I;  2L29 B;  2GF1 A;  1IGL A;  1ZEI A;  2LWZ A;  6INS E;  1H02 B;  1EFE A;  1TGR A;  3KR3 D;  1H59 A;  1PMX A;  2DSQ C;  4XSS B;  2KJI A;  1BQT A;  1SJU A;  1GZR B; 
#chains in the Genus database with same CATH topology
 2JZQ A;  1IMX A;  1GZY B;  5L3L A;  3F2D A;  2DSP I;  2DSR I;  3F2B A;  2KQP A;  5L3N A;  1B9G A;  1GZZ B;  5L3M A;  3GF1 A;  3LRI A;  1WQJ I;  2L29 B;  2GF1 A;  1IGL A;  1ZEI A;  2LWZ A;  6INS E;  3F2C A;  1H02 B;  1EFE A;  1TGR A;  3KR3 D;  1H59 A;  1PMX A;  2DSQ C;  2L14 B;  4XSS B;  2KJI A;  1BQT A;  1SJU A;  1GZR B; 
#chains in the Genus database with same CATH homology
 2JZQ A;  1IMX A;  1GZY B;  5L3L A;  2DSP I;  2DSR I;  2KQP A;  5L3N A;  1B9G A;  1GZZ B;  5L3M A;  3GF1 A;  3LRI A;  1WQJ I;  2L29 B;  2GF1 A;  1IGL A;  1ZEI A;  2LWZ A;  6INS E;  1H02 B;  1EFE A;  1TGR A;  3KR3 D;  1H59 A;  1PMX A;  2DSQ C;  4XSS B;  2KJI A;  1BQT A;  1SJU A;  1GZR B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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