2DSQC

Structural basis for the inhibition of insulin-like growth factors by igf binding proteins
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
62
structure length
51
Chain Sequence
PETLCGAELVDALQFVCGDRGFYFNKPTTGIVDECCFRSCDLRRLEMYCAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding/hormone/growth factor
molecule keywords Insulin-like growth factor-binding protein 4
publication title Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
pubmed doi rcsb
source organism Homo sapiens
total genus 15
structure length 51
sequence length 62
chains with identical sequence I
ec nomenclature
pdb deposition date 2006-07-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2dsqC00
1PMXA 5L3MA 2DSRI 2DSPI 2GF1A 1EFEA 1GZZB 2LWZA 1IMXA 3KR3D 1B9GA 6INSE 1TGRA 3GF1A 1WQJI 2L29B 2DSQC 1GZRB 2KQPA 2JZQA 4XSSB 1GZYB 2KJIA 5L3NA 1BQTA 5L3LA 1H02B 1IGLA 1H59A 3LRIA 1ZEIA 1SJUA
chains in the Genus database with same CATH superfamily
1PMXA 5L3MA 2DSRI 2DSPI 3F2CA 2GF1A 1EFEA 1GZZB 2LWZA 1IMXA 3KR3D 1B9GA 6INSE 1TGRA 3GF1A 3F2BA 3F2DA 1WQJI 2L29B 2DSQC 1GZRB 2KQPA 2JZQA 4XSSB 1GZYB 2KJIA 5L3NA 1BQTA 5L3LA 1H02B 1IGLA 2L14B 1H59A 3LRIA 1ZEIA 1SJUA
chains in the Genus database with same CATH topology
1PMXA 5L3MA 2DSRI 2DSPI 2GF1A 1EFEA 1GZZB 2LWZA 1IMXA 3KR3D 1B9GA 6INSE 1TGRA 3GF1A 1WQJI 2L29B 2DSQC 1GZRB 2KQPA 2JZQA 4XSSB 1GZYB 2KJIA 5L3NA 1BQTA 5L3LA 1H02B 1IGLA 1H59A 3LRIA 1ZEIA 1SJUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PMX A;  5L3M A;  2DSR I;  2DSP I;  2GF1 A;  1EFE A;  1GZZ B;  2LWZ A;  1IMX A;  3KR3 D;  1B9G A;  6INS E;  1TGR A;  3GF1 A;  1WQJ I;  2L29 B;  2DSQ C;  1GZR B;  2KQP A;  2JZQ A;  4XSS B;  1GZY B;  2KJI A;  5L3N A;  1BQT A;  5L3L A;  1H02 B;  1IGL A;  1H59 A;  3LRI A;  1ZEI A;  1SJU A; 
#chains in the Genus database with same CATH topology
 1PMX A;  5L3M A;  2DSR I;  2DSP I;  3F2C A;  2GF1 A;  1EFE A;  1GZZ B;  2LWZ A;  1IMX A;  3KR3 D;  1B9G A;  6INS E;  1TGR A;  3GF1 A;  3F2B A;  3F2D A;  1WQJ I;  2L29 B;  2DSQ C;  1GZR B;  2KQP A;  2JZQ A;  4XSS B;  1GZY B;  2KJI A;  5L3N A;  1BQT A;  5L3L A;  1H02 B;  1IGL A;  2L14 B;  1H59 A;  3LRI A;  1ZEI A;  1SJU A; 
#chains in the Genus database with same CATH homology
 1PMX A;  5L3M A;  2DSR I;  2DSP I;  2GF1 A;  1EFE A;  1GZZ B;  2LWZ A;  1IMX A;  3KR3 D;  1B9G A;  6INS E;  1TGR A;  3GF1 A;  1WQJ I;  2L29 B;  2DSQ C;  1GZR B;  2KQP A;  2JZQ A;  4XSS B;  1GZY B;  2KJI A;  5L3N A;  1BQT A;  5L3L A;  1H02 B;  1IGL A;  1H59 A;  3LRI A;  1ZEI A;  1SJU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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