2KQPA

Nmr structure of proinsulin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
86
structure length
86
Chain Sequence
FVNQHLCGSDLVEALYLVCGERGFFYTKPTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone
molecule keywords Insulin
publication title Solution structure of proinsulin: connecting domain flexibility and prohormone processing.
pubmed doi rcsb
source organism Homo sapiens
total genus 11
structure length 86
sequence length 86
ec nomenclature
pdb deposition date 2009-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2kqpA00
5L3LA 1ZEIA 3LRIA 1PMXA 1GZYB 1BQTA 1H59A 2JZQA 1SJUA 1IMXA 1H02B 6INSE 1GZZB 1GZRB 2KQPA 1B9GA 3KR3D 4XSSB 2LWZA 2DSQC 3GF1A 2L29B 1TGRA 2GF1A 2DSPI 1EFEA 1IGLA 2DSRI 2KJIA 5L3MA 5L3NA 1WQJI
chains in the Genus database with same CATH superfamily
5L3LA 1ZEIA 3LRIA 1PMXA 1GZYB 1BQTA 1H59A 2JZQA 1SJUA 1IMXA 1H02B 6INSE 3F2DA 1GZZB 1GZRB 2KQPA 2L14B 1B9GA 3F2CA 3KR3D 4XSSB 2LWZA 2DSQC 3GF1A 2L29B 1TGRA 3F2BA 2GF1A 2DSPI 1EFEA 1IGLA 2DSRI 2KJIA 5L3MA 5L3NA 1WQJI
chains in the Genus database with same CATH topology
5L3LA 1ZEIA 3LRIA 1PMXA 1GZYB 1BQTA 1H59A 2JZQA 1SJUA 1IMXA 1H02B 6INSE 1GZZB 1GZRB 2KQPA 1B9GA 3KR3D 4XSSB 2LWZA 2DSQC 3GF1A 2L29B 1TGRA 2GF1A 2DSPI 1EFEA 1IGLA 2DSRI 2KJIA 5L3MA 5L3NA 1WQJI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L3L A;  1ZEI A;  3LRI A;  1PMX A;  1GZY B;  1BQT A;  1H59 A;  2JZQ A;  1SJU A;  1IMX A;  1H02 B;  6INS E;  1GZZ B;  1GZR B;  2KQP A;  1B9G A;  3KR3 D;  4XSS B;  2LWZ A;  2DSQ C;  3GF1 A;  2L29 B;  1TGR A;  2GF1 A;  2DSP I;  1EFE A;  1IGL A;  2DSR I;  2KJI A;  5L3M A;  5L3N A;  1WQJ I; 
#chains in the Genus database with same CATH topology
 5L3L A;  1ZEI A;  3LRI A;  1PMX A;  1GZY B;  1BQT A;  1H59 A;  2JZQ A;  1SJU A;  1IMX A;  1H02 B;  6INS E;  3F2D A;  1GZZ B;  1GZR B;  2KQP A;  2L14 B;  1B9G A;  3F2C A;  3KR3 D;  4XSS B;  2LWZ A;  2DSQ C;  3GF1 A;  2L29 B;  1TGR A;  3F2B A;  2GF1 A;  2DSP I;  1EFE A;  1IGL A;  2DSR I;  2KJI A;  5L3M A;  5L3N A;  1WQJ I; 
#chains in the Genus database with same CATH homology
 5L3L A;  1ZEI A;  3LRI A;  1PMX A;  1GZY B;  1BQT A;  1H59 A;  2JZQ A;  1SJU A;  1IMX A;  1H02 B;  6INS E;  1GZZ B;  1GZR B;  2KQP A;  1B9G A;  3KR3 D;  4XSS B;  2LWZ A;  2DSQ C;  3GF1 A;  2L29 B;  1TGR A;  2GF1 A;  2DSP I;  1EFE A;  1IGL A;  2DSR I;  2KJI A;  5L3M A;  5L3N A;  1WQJ I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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