2DSRI

Structural basis for the inhibition of insulin-like growth factors by igf binding proteins
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
63
structure length
60
Chain Sequence
PETLCGAELVDALQFVCGDRGFYFNKPTGYGSSAPQTGIVDECCFRSCDLRRLEMYCAPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding/hormone/growth factor
molecule keywords Insulin-like growth factor-binding protein 4
publication title Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
pubmed doi rcsb
source organism Homo sapiens
total genus 16
structure length 60
sequence length 63
ec nomenclature
pdb deposition date 2006-07-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 2dsrI00
2KQPA 1H59A 1WQJI 1ZEIA 3LRIA 1BQTA 4XSSB 5L3LA 5L3NA 2DSRI 2LWZA 3KR3D 2DSPI 1PMXA 6INSE 3GF1A 1EFEA 1SJUA 2L29B 5L3MA 1IMXA 2GF1A 1TGRA 2JZQA 1IGLA 1GZYB 1H02B 1B9GA 2KJIA 1GZRB 2DSQC 1GZZB
chains in the Genus database with same CATH superfamily
2L14B 2KQPA 1H59A 1WQJI 1ZEIA 3LRIA 1BQTA 4XSSB 5L3LA 5L3NA 2DSRI 2LWZA 3KR3D 2DSPI 1PMXA 3F2BA 6INSE 3F2CA 3GF1A 1EFEA 1SJUA 2L29B 5L3MA 1IMXA 2GF1A 1TGRA 3F2DA 2JZQA 1IGLA 1GZYB 1H02B 1B9GA 2KJIA 1GZRB 2DSQC 1GZZB
chains in the Genus database with same CATH topology
2KQPA 1H59A 1WQJI 1ZEIA 3LRIA 1BQTA 4XSSB 5L3LA 5L3NA 2DSRI 2LWZA 3KR3D 2DSPI 1PMXA 6INSE 3GF1A 1EFEA 1SJUA 2L29B 5L3MA 1IMXA 2GF1A 1TGRA 2JZQA 1IGLA 1GZYB 1H02B 1B9GA 2KJIA 1GZRB 2DSQC 1GZZB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KQP A;  1H59 A;  1WQJ I;  1ZEI A;  3LRI A;  1BQT A;  4XSS B;  5L3L A;  5L3N A;  2DSR I;  2LWZ A;  3KR3 D;  2DSP I;  1PMX A;  6INS E;  3GF1 A;  1EFE A;  1SJU A;  2L29 B;  5L3M A;  1IMX A;  2GF1 A;  1TGR A;  2JZQ A;  1IGL A;  1GZY B;  1H02 B;  1B9G A;  2KJI A;  1GZR B;  2DSQ C;  1GZZ B; 
#chains in the Genus database with same CATH topology
 2L14 B;  2KQP A;  1H59 A;  1WQJ I;  1ZEI A;  3LRI A;  1BQT A;  4XSS B;  5L3L A;  5L3N A;  2DSR I;  2LWZ A;  3KR3 D;  2DSP I;  1PMX A;  3F2B A;  6INS E;  3F2C A;  3GF1 A;  1EFE A;  1SJU A;  2L29 B;  5L3M A;  1IMX A;  2GF1 A;  1TGR A;  3F2D A;  2JZQ A;  1IGL A;  1GZY B;  1H02 B;  1B9G A;  2KJI A;  1GZR B;  2DSQ C;  1GZZ B; 
#chains in the Genus database with same CATH homology
 2KQP A;  1H59 A;  1WQJ I;  1ZEI A;  3LRI A;  1BQT A;  4XSS B;  5L3L A;  5L3N A;  2DSR I;  2LWZ A;  3KR3 D;  2DSP I;  1PMX A;  6INS E;  3GF1 A;  1EFE A;  1SJU A;  2L29 B;  5L3M A;  1IMX A;  2GF1 A;  1TGR A;  2JZQ A;  1IGL A;  1GZY B;  1H02 B;  1B9G A;  2KJI A;  1GZR B;  2DSQ C;  1GZZ B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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