1JMOL

Crystal structure of the heparin cofactor ii-s195a thrombin complex
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
47
structure length
47
Chain Sequence
ATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
pubmed doi rcsb
molecule tags Blood clotting
source organism Homo sapiens
molecule keywords Thrombin, light chain
total genus 3
structure length 47
sequence length 47
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2001-07-19
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 1jmoL00
3EDXA 4DY7A 2PGQA 1Z8JA 3BEFA 3E6PL 2PV9A 2A1DA 3LU9A 2ODYA 1JMOL 3HK6A 2B5TA 1JOUA 1TB6L 1TBQJ 3B9FL 1AVGL 3GISA 1TBRJ 3HKIA 1TQ7A 4RKOA 2PUXA 1A0HA 3BEIA
chains in the Genus database with same CATH superfamily
3EDXA 4DY7A 2PGQA 1Z8JA 3BEFA 3E6PL 2PV9A 2A1DA 3LU9A 2ODYA 1JMOL 3HK6A 2B5TA 1JOUA 1TB6L 1TBQJ 3B9FL 1AVGL 3GISA 1TBRJ 3HKIA 1TQ7A 4RKOA 2PUXA 1A0HA 3BEIA
chains in the Genus database with same CATH topology
3EDXA 4DY7A 2PGQA 1Z8JA 3BEFA 3E6PL 2PV9A 2A1DA 3LU9A 2ODYA 1JMOL 3HK6A 2B5TA 1JOUA 1TB6L 1TBQJ 3B9FL 1AVGL 3GISA 1TBRJ 3HKIA 1TQ7A 4RKOA 2PUXA 1A0HA 3BEIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EDX A;  4DY7 A;  2PGQ A;  1Z8J A;  3BEF A;  3E6P L;  2PV9 A;  2A1D A;  3LU9 A;  2ODY A;  1JMO L;  3HK6 A;  2B5T A;  1JOU A;  1TB6 L;  1TBQ J;  3B9F L;  1AVG L;  3GIS A;  1TBR J;  3HKI A;  1TQ7 A;  4RKO A;  2PUX A;  1A0H A;  3BEI A; 
#chains in the Genus database with same CATH topology
 3EDX A;  4DY7 A;  2PGQ A;  1Z8J A;  3BEF A;  3E6P L;  2PV9 A;  2A1D A;  3LU9 A;  2ODY A;  1JMO L;  3HK6 A;  2B5T A;  1JOU A;  1TB6 L;  1TBQ J;  3B9F L;  1AVG L;  3GIS A;  1TBR J;  3HKI A;  1TQ7 A;  4RKO A;  2PUX A;  1A0H A;  3BEI A; 
#chains in the Genus database with same CATH homology
 3EDX A;  4DY7 A;  2PGQ A;  1Z8J A;  3BEF A;  3E6P L;  2PV9 A;  2A1D A;  3LU9 A;  2ODY A;  1JMO L;  3HK6 A;  2B5T A;  1JOU A;  1TB6 L;  1TBQ J;  3B9F L;  1AVG L;  3GIS A;  1TBR J;  3HKI A;  1TQ7 A;  4RKO A;  2PUX A;  1A0H A;  3BEI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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