1JMOL

Crystal structure of the heparin cofactor ii-s195a thrombin complex
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
47
structure length
47
Chain Sequence
ATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
pubmed doi rcsb
molecule tags Blood clotting
source organism Homo sapiens
molecule keywords Thrombin, light chain
total genus 3
structure length 47
sequence length 47
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2001-07-19
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 1jmoL00
1TBQJ 1TQ7A 2PGQA 2B5TA 1JMOL 1TBRJ 4DY7A 2PV9A 3HKIA 2PUXA 3B9FL 3E6PL 2ODYA 1AVGL 3EDXA 3BEFA 2A1DA 1Z8JA 3HK6A 4RKOA 3LU9A 1A0HA 3GISA 1JOUA 3BEIA 1TB6L
chains in the Genus database with same CATH superfamily
1TBQJ 1TQ7A 2PGQA 2B5TA 1JMOL 1TBRJ 4DY7A 2PV9A 3HKIA 2PUXA 3B9FL 3E6PL 2ODYA 1AVGL 3EDXA 3BEFA 2A1DA 1Z8JA 3HK6A 4RKOA 3LU9A 1A0HA 3GISA 1JOUA 3BEIA 1TB6L
chains in the Genus database with same CATH topology
1TBQJ 1TQ7A 2PGQA 2B5TA 1JMOL 1TBRJ 4DY7A 2PV9A 3HKIA 2PUXA 3B9FL 3E6PL 2ODYA 1AVGL 3EDXA 3BEFA 2A1DA 1Z8JA 3HK6A 4RKOA 3LU9A 1A0HA 3GISA 1JOUA 3BEIA 1TB6L
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TBQ J;  1TQ7 A;  2PGQ A;  2B5T A;  1JMO L;  1TBR J;  4DY7 A;  2PV9 A;  3HKI A;  2PUX A;  3B9F L;  3E6P L;  2ODY A;  1AVG L;  3EDX A;  3BEF A;  2A1D A;  1Z8J A;  3HK6 A;  4RKO A;  3LU9 A;  1A0H A;  3GIS A;  1JOU A;  3BEI A;  1TB6 L; 
#chains in the Genus database with same CATH topology
 1TBQ J;  1TQ7 A;  2PGQ A;  2B5T A;  1JMO L;  1TBR J;  4DY7 A;  2PV9 A;  3HKI A;  2PUX A;  3B9F L;  3E6P L;  2ODY A;  1AVG L;  3EDX A;  3BEF A;  2A1D A;  1Z8J A;  3HK6 A;  4RKO A;  3LU9 A;  1A0H A;  3GIS A;  1JOU A;  3BEI A;  1TB6 L; 
#chains in the Genus database with same CATH homology
 1TBQ J;  1TQ7 A;  2PGQ A;  2B5T A;  1JMO L;  1TBR J;  4DY7 A;  2PV9 A;  3HKI A;  2PUX A;  3B9F L;  3E6P L;  2ODY A;  1AVG L;  3EDX A;  3BEF A;  2A1D A;  1Z8J A;  3HK6 A;  4RKO A;  3LU9 A;  1A0H A;  3GIS A;  1JOU A;  3BEI A;  1TB6 L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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