2PGQA

Human thrombin mutant c191a-c220a in complex with the inhibitor ppack
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
43
structure length
43
Chain Sequence
EYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Prothrombin
publication title Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 43
sequence length 43
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2007-04-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 2pgqA00
2ODYA 2PV9A 1JOUA 3GISA 4RKOA 3BEIA 2PUXA 2PGQA 3BEFA 1JMOL 2A1DA 3E6PL 3HK6A 3EDXA 1TBRJ 4DY7A 1Z8JA 2B5TA 1AVGL 1A0HA 3B9FL 3HKIA 3LU9A 1TB6L 1TQ7A 1TBQJ
chains in the Genus database with same CATH superfamily
2ODYA 2PV9A 1JOUA 3GISA 4RKOA 3BEIA 2PUXA 2PGQA 3BEFA 1JMOL 2A1DA 3E6PL 3HK6A 3EDXA 1TBRJ 4DY7A 1Z8JA 2B5TA 1AVGL 1A0HA 3B9FL 3HKIA 3LU9A 1TB6L 1TQ7A 1TBQJ
chains in the Genus database with same CATH topology
2ODYA 2PV9A 1JOUA 3GISA 4RKOA 3BEIA 2PUXA 2PGQA 3BEFA 1JMOL 2A1DA 3E6PL 3HK6A 3EDXA 1TBRJ 4DY7A 1Z8JA 2B5TA 1AVGL 1A0HA 3B9FL 3HKIA 3LU9A 1TB6L 1TQ7A 1TBQJ
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ODY A;  2PV9 A;  1JOU A;  3GIS A;  4RKO A;  3BEI A;  2PUX A;  2PGQ A;  3BEF A;  1JMO L;  2A1D A;  3E6P L;  3HK6 A;  3EDX A;  1TBR J;  4DY7 A;  1Z8J A;  2B5T A;  1AVG L;  1A0H A;  3B9F L;  3HKI A;  3LU9 A;  1TB6 L;  1TQ7 A;  1TBQ J; 
#chains in the Genus database with same CATH topology
 2ODY A;  2PV9 A;  1JOU A;  3GIS A;  4RKO A;  3BEI A;  2PUX A;  2PGQ A;  3BEF A;  1JMO L;  2A1D A;  3E6P L;  3HK6 A;  3EDX A;  1TBR J;  4DY7 A;  1Z8J A;  2B5T A;  1AVG L;  1A0H A;  3B9F L;  3HKI A;  3LU9 A;  1TB6 L;  1TQ7 A;  1TBQ J; 
#chains in the Genus database with same CATH homology
 2ODY A;  2PV9 A;  1JOU A;  3GIS A;  4RKO A;  3BEI A;  2PUX A;  2PGQ A;  3BEF A;  1JMO L;  2A1D A;  3E6P L;  3HK6 A;  3EDX A;  1TBR J;  4DY7 A;  1Z8J A;  2B5T A;  1AVG L;  1A0H A;  3B9F L;  3HKI A;  3LU9 A;  1TB6 L;  1TQ7 A;  1TBQ J; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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