2B5TA

2.1 angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic sr123781 and two s195a thrombin molecules
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
47
structure length
47
Chain Sequence
TSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
pubmed doi rcsb
molecule keywords Thrombin
molecule tags Blood clotting
source organism Homo sapiens
total genus 3
structure length 47
sequence length 47
chains with identical sequence C
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2005-09-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09396 Thrombin_light Thrombin light chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 2b5tA00
2PUXA 3LU9A 3HK6A 1TQ7A 1A0HA 2ODYA 3EDXA 1JMOL 1JOUA 3B9FL 1AVGL 2PGQA 3HKIA 2B5TA 2A1DA 4DY7A 1Z8JA 3GISA 3BEFA 1TBRJ 1TBQJ 4RKOA 2PV9A 3E6PL 1TB6L 3BEIA
chains in the Genus database with same CATH superfamily
2PUXA 3LU9A 3HK6A 1TQ7A 1A0HA 2ODYA 3EDXA 1JMOL 1JOUA 3B9FL 1AVGL 2PGQA 3HKIA 2B5TA 2A1DA 4DY7A 1Z8JA 3GISA 3BEFA 1TBRJ 1TBQJ 4RKOA 2PV9A 3E6PL 1TB6L 3BEIA
chains in the Genus database with same CATH topology
2PUXA 3LU9A 3HK6A 1TQ7A 1A0HA 2ODYA 3EDXA 1JMOL 1JOUA 3B9FL 1AVGL 2PGQA 3HKIA 2B5TA 2A1DA 4DY7A 1Z8JA 3GISA 3BEFA 1TBRJ 1TBQJ 4RKOA 2PV9A 3E6PL 1TB6L 3BEIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PUX A;  3LU9 A;  3HK6 A;  1TQ7 A;  1A0H A;  2ODY A;  3EDX A;  1JMO L;  1JOU A;  3B9F L;  1AVG L;  2PGQ A;  3HKI A;  2B5T A;  2A1D A;  4DY7 A;  1Z8J A;  3GIS A;  3BEF A;  1TBR J;  1TBQ J;  4RKO A;  2PV9 A;  3E6P L;  1TB6 L;  3BEI A; 
#chains in the Genus database with same CATH topology
 2PUX A;  3LU9 A;  3HK6 A;  1TQ7 A;  1A0H A;  2ODY A;  3EDX A;  1JMO L;  1JOU A;  3B9F L;  1AVG L;  2PGQ A;  3HKI A;  2B5T A;  2A1D A;  4DY7 A;  1Z8J A;  3GIS A;  3BEF A;  1TBR J;  1TBQ J;  4RKO A;  2PV9 A;  3E6P L;  1TB6 L;  3BEI A; 
#chains in the Genus database with same CATH homology
 2PUX A;  3LU9 A;  3HK6 A;  1TQ7 A;  1A0H A;  2ODY A;  3EDX A;  1JMO L;  1JOU A;  3B9F L;  1AVG L;  2PGQ A;  3HKI A;  2B5T A;  2A1D A;  4DY7 A;  1Z8J A;  3GIS A;  3BEF A;  1TBR J;  1TBQ J;  4RKO A;  2PV9 A;  3E6P L;  1TB6 L;  3BEI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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