3GISA

Crystal structure of na-free thrombin in complex with thrombomodulin
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
46
structure length
46
Chain Sequence
SEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Blood clotting
molecule keywords Prothrombin
publication title Molecular basis of thrombomodulin activation of slow thrombin
pubmed doi rcsb
source organism Homo sapiens
total genus 3
structure length 46
sequence length 46
chains with identical sequence C, E
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2009-03-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09396 Thrombin_light Thrombin light chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 3gisA00
3B9FL 2PGQA 2ODYA 2PV9A 3GISA 4DY7A 1TB6L 1A0HA 2A1DA 1JMOL 2B5TA 1TBRJ 2PUXA 3E6PL 3HKIA 1Z8JA 3BEIA 3HK6A 1JOUA 3BEFA 4RKOA 1AVGL 1TQ7A 3EDXA 3LU9A 1TBQJ
chains in the Genus database with same CATH superfamily
3B9FL 2PGQA 2ODYA 2PV9A 3GISA 4DY7A 1TB6L 1A0HA 2A1DA 1JMOL 2B5TA 1TBRJ 2PUXA 3E6PL 3HKIA 1Z8JA 3BEIA 3HK6A 1JOUA 3BEFA 4RKOA 1AVGL 1TQ7A 3EDXA 3LU9A 1TBQJ
chains in the Genus database with same CATH topology
3B9FL 2PGQA 2ODYA 2PV9A 3GISA 4DY7A 1TB6L 1A0HA 2A1DA 1JMOL 2B5TA 1TBRJ 2PUXA 3E6PL 3HKIA 1Z8JA 3BEIA 3HK6A 1JOUA 3BEFA 4RKOA 1AVGL 1TQ7A 3EDXA 3LU9A 1TBQJ
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3B9F L;  2PGQ A;  2ODY A;  2PV9 A;  3GIS A;  4DY7 A;  1TB6 L;  1A0H A;  2A1D A;  1JMO L;  2B5T A;  1TBR J;  2PUX A;  3E6P L;  3HKI A;  1Z8J A;  3BEI A;  3HK6 A;  1JOU A;  3BEF A;  4RKO A;  1AVG L;  1TQ7 A;  3EDX A;  3LU9 A;  1TBQ J; 
#chains in the Genus database with same CATH topology
 3B9F L;  2PGQ A;  2ODY A;  2PV9 A;  3GIS A;  4DY7 A;  1TB6 L;  1A0H A;  2A1D A;  1JMO L;  2B5T A;  1TBR J;  2PUX A;  3E6P L;  3HKI A;  1Z8J A;  3BEI A;  3HK6 A;  1JOU A;  3BEF A;  4RKO A;  1AVG L;  1TQ7 A;  3EDX A;  3LU9 A;  1TBQ J; 
#chains in the Genus database with same CATH homology
 3B9F L;  2PGQ A;  2ODY A;  2PV9 A;  3GIS A;  4DY7 A;  1TB6 L;  1A0H A;  2A1D A;  1JMO L;  2B5T A;  1TBR J;  2PUX A;  3E6P L;  3HKI A;  1Z8J A;  3BEI A;  3HK6 A;  1JOU A;  3BEF A;  4RKO A;  1AVG L;  1TQ7 A;  3EDX A;  3LU9 A;  1TBQ J; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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