1TB6L

2.5a crystal structure of the antithrombin-thrombin-heparin ternary complex
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
SEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/blood clotting
molecule keywords thrombin
publication title Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.
pubmed doi rcsb
source organism Homo sapiens
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2004-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF09396 Thrombin_light Thrombin light chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 1tb6L00
3EDXA 3E6PL 3HK6A 3BEIA 2B5TA 4RKOA 1A0HA 1TQ7A 3GISA 1TBRJ 2PGQA 4DY7A 1Z8JA 1AVGL 1TB6L 3B9FL 2A1DA 3LU9A 2PV9A 1JOUA 1TBQJ 2PUXA 3HKIA 1JMOL 2ODYA 3BEFA
chains in the Genus database with same CATH superfamily
3EDXA 3E6PL 3HK6A 3BEIA 2B5TA 4RKOA 1A0HA 1TQ7A 3GISA 1TBRJ 2PGQA 4DY7A 1Z8JA 1AVGL 1TB6L 3B9FL 2A1DA 3LU9A 2PV9A 1JOUA 1TBQJ 2PUXA 3HKIA 1JMOL 2ODYA 3BEFA
chains in the Genus database with same CATH topology
3EDXA 3E6PL 3HK6A 3BEIA 2B5TA 4RKOA 1A0HA 1TQ7A 3GISA 1TBRJ 2PGQA 4DY7A 1Z8JA 1AVGL 1TB6L 3B9FL 2A1DA 3LU9A 2PV9A 1JOUA 1TBQJ 2PUXA 3HKIA 1JMOL 2ODYA 3BEFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EDX A;  3E6P L;  3HK6 A;  3BEI A;  2B5T A;  4RKO A;  1A0H A;  1TQ7 A;  3GIS A;  1TBR J;  2PGQ A;  4DY7 A;  1Z8J A;  1AVG L;  1TB6 L;  3B9F L;  2A1D A;  3LU9 A;  2PV9 A;  1JOU A;  1TBQ J;  2PUX A;  3HKI A;  1JMO L;  2ODY A;  3BEF A; 
#chains in the Genus database with same CATH topology
 3EDX A;  3E6P L;  3HK6 A;  3BEI A;  2B5T A;  4RKO A;  1A0H A;  1TQ7 A;  3GIS A;  1TBR J;  2PGQ A;  4DY7 A;  1Z8J A;  1AVG L;  1TB6 L;  3B9F L;  2A1D A;  3LU9 A;  2PV9 A;  1JOU A;  1TBQ J;  2PUX A;  3HKI A;  1JMO L;  2ODY A;  3BEF A; 
#chains in the Genus database with same CATH homology
 3EDX A;  3E6P L;  3HK6 A;  3BEI A;  2B5T A;  4RKO A;  1A0H A;  1TQ7 A;  3GIS A;  1TBR J;  2PGQ A;  4DY7 A;  1Z8J A;  1AVG L;  1TB6 L;  3B9F L;  2A1D A;  3LU9 A;  2PV9 A;  1JOU A;  1TBQ J;  2PUX A;  3HKI A;  1JMO L;  2ODY A;  3BEF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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