1TQ7A

Crystal structure of the anticoagulant thrombin mutant w215a/e217a bound to ppack
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
44
structure length
44
Chain Sequence
YQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Prothrombin
publication title The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket
pubmed doi rcsb
source organism Homo sapiens
total genus 3
structure length 44
sequence length 44
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2004-06-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 1tq7A00
3E6PL 1TQ7A 2PUXA 4DY7A 1A0HA 2PGQA 2B5TA 3BEIA 1JOUA 3LU9A 3BEFA 1TBQJ 3B9FL 2PV9A 1Z8JA 4RKOA 3HKIA 1TB6L 1JMOL 1AVGL 3EDXA 2ODYA 3GISA 3HK6A 1TBRJ 2A1DA
chains in the Genus database with same CATH superfamily
3E6PL 1TQ7A 2PUXA 4DY7A 1A0HA 2PGQA 2B5TA 3BEIA 1JOUA 3LU9A 3BEFA 1TBQJ 3B9FL 2PV9A 1Z8JA 4RKOA 3HKIA 1TB6L 1JMOL 1AVGL 3EDXA 2ODYA 3GISA 3HK6A 1TBRJ 2A1DA
chains in the Genus database with same CATH topology
3E6PL 1TQ7A 2PUXA 4DY7A 1A0HA 2PGQA 2B5TA 3BEIA 1JOUA 3LU9A 3BEFA 1TBQJ 3B9FL 2PV9A 1Z8JA 4RKOA 3HKIA 1TB6L 1JMOL 1AVGL 3EDXA 2ODYA 3GISA 3HK6A 1TBRJ 2A1DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E6P L;  1TQ7 A;  2PUX A;  4DY7 A;  1A0H A;  2PGQ A;  2B5T A;  3BEI A;  1JOU A;  3LU9 A;  3BEF A;  1TBQ J;  3B9F L;  2PV9 A;  1Z8J A;  4RKO A;  3HKI A;  1TB6 L;  1JMO L;  1AVG L;  3EDX A;  2ODY A;  3GIS A;  3HK6 A;  1TBR J;  2A1D A; 
#chains in the Genus database with same CATH topology
 3E6P L;  1TQ7 A;  2PUX A;  4DY7 A;  1A0H A;  2PGQ A;  2B5T A;  3BEI A;  1JOU A;  3LU9 A;  3BEF A;  1TBQ J;  3B9F L;  2PV9 A;  1Z8J A;  4RKO A;  3HKI A;  1TB6 L;  1JMO L;  1AVG L;  3EDX A;  2ODY A;  3GIS A;  3HK6 A;  1TBR J;  2A1D A; 
#chains in the Genus database with same CATH homology
 3E6P L;  1TQ7 A;  2PUX A;  4DY7 A;  1A0H A;  2PGQ A;  2B5T A;  3BEI A;  1JOU A;  3LU9 A;  3BEF A;  1TBQ J;  3B9F L;  2PV9 A;  1Z8J A;  4RKO A;  3HKI A;  1TB6 L;  1JMO L;  1AVG L;  3EDX A;  2ODY A;  3GIS A;  3HK6 A;  1TBR J;  2A1D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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