1Z8JA

Crystal structure of the thrombin mutant g193p bound to ppack
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
40
structure length
40
Chain Sequence
TFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Thrombin light chain
total genus 1
structure length 40
sequence length 40
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2005-03-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 1z8jA00
3HK6A 1TBRJ 2PGQA 3B9FL 3E6PL 2PV9A 3BEIA 3EDXA 3BEFA 3GISA 1TB6L 1JMOL 1TQ7A 2PUXA 2B5TA 1JOUA 4RKOA 1A0HA 3LU9A 2ODYA 4DY7A 1TBQJ 1AVGL 1Z8JA 2A1DA 3HKIA
chains in the Genus database with same CATH superfamily
3HK6A 1TBRJ 2PGQA 3B9FL 3E6PL 2PV9A 3BEIA 3EDXA 3BEFA 3GISA 1TB6L 1JMOL 1TQ7A 2PUXA 2B5TA 1JOUA 4RKOA 1A0HA 3LU9A 2ODYA 4DY7A 1TBQJ 1AVGL 1Z8JA 2A1DA 3HKIA
chains in the Genus database with same CATH topology
3HK6A 1TBRJ 2PGQA 3B9FL 3E6PL 2PV9A 3BEIA 3EDXA 3BEFA 3GISA 1TB6L 1JMOL 1TQ7A 2PUXA 2B5TA 1JOUA 4RKOA 1A0HA 3LU9A 2ODYA 4DY7A 1TBQJ 1AVGL 1Z8JA 2A1DA 3HKIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HK6 A;  1TBR J;  2PGQ A;  3B9F L;  3E6P L;  2PV9 A;  3BEI A;  3EDX A;  3BEF A;  3GIS A;  1TB6 L;  1JMO L;  1TQ7 A;  2PUX A;  2B5T A;  1JOU A;  4RKO A;  1A0H A;  3LU9 A;  2ODY A;  4DY7 A;  1TBQ J;  1AVG L;  1Z8J A;  2A1D A;  3HKI A; 
#chains in the Genus database with same CATH topology
 3HK6 A;  1TBR J;  2PGQ A;  3B9F L;  3E6P L;  2PV9 A;  3BEI A;  3EDX A;  3BEF A;  3GIS A;  1TB6 L;  1JMO L;  1TQ7 A;  2PUX A;  2B5T A;  1JOU A;  4RKO A;  1A0H A;  3LU9 A;  2ODY A;  4DY7 A;  1TBQ J;  1AVG L;  1Z8J A;  2A1D A;  3HKI A; 
#chains in the Genus database with same CATH homology
 3HK6 A;  1TBR J;  2PGQ A;  3B9F L;  3E6P L;  2PV9 A;  3BEI A;  3EDX A;  3BEF A;  3GIS A;  1TB6 L;  1JMO L;  1TQ7 A;  2PUX A;  2B5T A;  1JOU A;  4RKO A;  1A0H A;  3LU9 A;  2ODY A;  4DY7 A;  1TBQ J;  1AVG L;  1Z8J A;  2A1D A;  3HKI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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