1JOUA

Crystal structure of native s195a thrombin with an unoccupied active site
Total Genus 4
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
4
sequence length
45
structure length
45
Chain Sequence
SEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The molecular basis of thrombin allostery revealed by a 1.8A structure of the slow form
pubmed doi rcsb
molecule tags Blood clotting
source organism Homo sapiens
molecule keywords Thrombin, light chain
total genus 4
structure length 45
sequence length 45
chains with identical sequence C, E
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2001-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09396 Thrombin_light Thrombin light chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 1jouA00
2PGQA 3HK6A 3BEFA 3GISA 3EDXA 3HKIA 3E6PL 2PUXA 1AVGL 1TQ7A 3B9FL 1TBRJ 1A0HA 4RKOA 3BEIA 2ODYA 1TB6L 2B5TA 4DY7A 1TBQJ 1Z8JA 1JMOL 1JOUA 3LU9A 2PV9A 2A1DA
chains in the Genus database with same CATH superfamily
2PGQA 3HK6A 3BEFA 3GISA 3EDXA 3HKIA 3E6PL 2PUXA 1AVGL 1TQ7A 3B9FL 1TBRJ 1A0HA 4RKOA 3BEIA 2ODYA 1TB6L 2B5TA 4DY7A 1TBQJ 1Z8JA 1JMOL 1JOUA 3LU9A 2PV9A 2A1DA
chains in the Genus database with same CATH topology
2PGQA 3HK6A 3BEFA 3GISA 3EDXA 3HKIA 3E6PL 2PUXA 1AVGL 1TQ7A 3B9FL 1TBRJ 1A0HA 4RKOA 3BEIA 2ODYA 1TB6L 2B5TA 4DY7A 1TBQJ 1Z8JA 1JMOL 1JOUA 3LU9A 2PV9A 2A1DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PGQ A;  3HK6 A;  3BEF A;  3GIS A;  3EDX A;  3HKI A;  3E6P L;  2PUX A;  1AVG L;  1TQ7 A;  3B9F L;  1TBR J;  1A0H A;  4RKO A;  3BEI A;  2ODY A;  1TB6 L;  2B5T A;  4DY7 A;  1TBQ J;  1Z8J A;  1JMO L;  1JOU A;  3LU9 A;  2PV9 A;  2A1D A; 
#chains in the Genus database with same CATH topology
 2PGQ A;  3HK6 A;  3BEF A;  3GIS A;  3EDX A;  3HKI A;  3E6P L;  2PUX A;  1AVG L;  1TQ7 A;  3B9F L;  1TBR J;  1A0H A;  4RKO A;  3BEI A;  2ODY A;  1TB6 L;  2B5T A;  4DY7 A;  1TBQ J;  1Z8J A;  1JMO L;  1JOU A;  3LU9 A;  2PV9 A;  2A1D A; 
#chains in the Genus database with same CATH homology
 2PGQ A;  3HK6 A;  3BEF A;  3GIS A;  3EDX A;  3HKI A;  3E6P L;  2PUX A;  1AVG L;  1TQ7 A;  3B9F L;  1TBR J;  1A0H A;  4RKO A;  3BEI A;  2ODY A;  1TB6 L;  2B5T A;  4DY7 A;  1TBQ J;  1Z8J A;  1JMO L;  1JOU A;  3LU9 A;  2PV9 A;  2A1D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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