2WJ1A

3d-crystal structure of humanized-rat fatty acid amide hydrolase (faah) conjugated with 7-phenyl-1-(4-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole
Total Genus 226
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
226
sequence length
543
structure length
543
Chain Sequence
RQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords FATTY-ACID AMIDE HYDROLASE 1
total genus 226
structure length 543
sequence length 543
chains with identical sequence B
ec nomenclature ec 3.5.1.99: Fatty acid amide hydrolase.
pdb deposition date 2009-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01425 Amidase Amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1300.10 Alpha Beta Alpha-Beta Complex Amidase signature (AS) enzymes Amidase signature (AS) domain 2wj1A00
2WJ1A 3H0LA 1OBIA 3H0MA 4GYSA 1MT5A 4N0IA 2DC0A 3A1IA 1O9OA 3QK5A 4YJIA 1M22A 3H0RA 3A2QA 5EWQA 3KFUE 1OCLA 1O9NA 1OBJA 1OCMA 2G5HA 4WJ3A 3K7FA 4CP8A 3PPMA 4YJ6A 2VYAA 3AL0A 2G5IA 4HBPA 1M21A 3K84A 3LJ6A 2DQNA 3QKVA 1OBLA 3QJ9A 3A1KA 3K83A 1OCKA 2WJ2A 1O9PA 4N0HA 4GYRA 1OCHA 2DF4A 2WAPA 2GI3A 3LJ7A 3PR0A 1O9QA 2F2AA 3OJ8A 3IP4A 4J5PA 4ISSA 3A2PA 4ISTA 4DO3A 3QJ8A 5AC3A 1OBKA
chains in the Genus database with same CATH superfamily
2WJ1A 3H0LA 1OBIA 3H0MA 4GYSA 1MT5A 4N0IA 2DC0A 3A1IA 1O9OA 3QK5A 4YJIA 1M22A 3H0RA 3A2QA 5EWQA 3KFUE 1OCLA 1O9NA 1OBJA 1OCMA 2G5HA 4WJ3A 3K7FA 4CP8A 3PPMA 4YJ6A 2VYAA 3AL0A 2G5IA 4HBPA 1M21A 3K84A 3LJ6A 2DQNA 3QKVA 1OBLA 3QJ9A 3A1KA 3K83A 1OCKA 2WJ2A 1O9PA 4N0HA 4GYRA 1OCHA 2DF4A 2WAPA 2GI3A 3LJ7A 3PR0A 1O9QA 2F2AA 3OJ8A 3IP4A 4J5PA 4ISSA 3A2PA 4ISTA 4DO3A 3QJ8A 5AC3A 1OBKA
chains in the Genus database with same CATH topology
2WJ1A 3H0LA 1OBIA 3H0MA 4GYSA 1MT5A 4N0IA 2DC0A 3A1IA 1O9OA 3QK5A 4YJIA 1M22A 3H0RA 3A2QA 5EWQA 3KFUE 1OCLA 1O9NA 1OBJA 1OCMA 2G5HA 4WJ3A 3K7FA 4CP8A 3PPMA 4YJ6A 2VYAA 3AL0A 2G5IA 4HBPA 1M21A 3K84A 3LJ6A 2DQNA 3QKVA 1OBLA 3QJ9A 3A1KA 3K83A 1OCKA 2WJ2A 1O9PA 4N0HA 4GYRA 1OCHA 2DF4A 2WAPA 2GI3A 3LJ7A 3PR0A 1O9QA 2F2AA 3OJ8A 3IP4A 4J5PA 4ISSA 3A2PA 4ISTA 4DO3A 3QJ8A 5AC3A 1OBKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WJ1 A;  3H0L A;  1OBI A;  3H0M A;  4GYS A;  1MT5 A;  4N0I A;  2DC0 A;  3A1I A;  1O9O A;  3QK5 A;  4YJI A;  1M22 A;  3H0R A;  3A2Q A;  5EWQ A;  3KFU E;  1OCL A;  1O9N A;  1OBJ A;  1OCM A;  2G5H A;  4WJ3 A;  3K7F A;  4CP8 A;  3PPM A;  4YJ6 A;  2VYA A;  3AL0 A;  2G5I A;  4HBP A;  1M21 A;  3K84 A;  3LJ6 A;  2DQN A;  3QKV A;  1OBL A;  3QJ9 A;  3A1K A;  3K83 A;  1OCK A;  2WJ2 A;  1O9P A;  4N0H A;  4GYR A;  1OCH A;  2DF4 A;  2WAP A;  2GI3 A;  3LJ7 A;  3PR0 A;  1O9Q A;  2F2A A;  3OJ8 A;  3IP4 A;  4J5P A;  4ISS A;  3A2P A;  4IST A;  4DO3 A;  3QJ8 A;  5AC3 A;  1OBK A; 
#chains in the Genus database with same CATH topology
 2WJ1 A;  3H0L A;  1OBI A;  3H0M A;  4GYS A;  1MT5 A;  4N0I A;  2DC0 A;  3A1I A;  1O9O A;  3QK5 A;  4YJI A;  1M22 A;  3H0R A;  3A2Q A;  5EWQ A;  3KFU E;  1OCL A;  1O9N A;  1OBJ A;  1OCM A;  2G5H A;  4WJ3 A;  3K7F A;  4CP8 A;  3PPM A;  4YJ6 A;  2VYA A;  3AL0 A;  2G5I A;  4HBP A;  1M21 A;  3K84 A;  3LJ6 A;  2DQN A;  3QKV A;  1OBL A;  3QJ9 A;  3A1K A;  3K83 A;  1OCK A;  2WJ2 A;  1O9P A;  4N0H A;  4GYR A;  1OCH A;  2DF4 A;  2WAP A;  2GI3 A;  3LJ7 A;  3PR0 A;  1O9Q A;  2F2A A;  3OJ8 A;  3IP4 A;  4J5P A;  4ISS A;  3A2P A;  4IST A;  4DO3 A;  3QJ8 A;  5AC3 A;  1OBK A; 
#chains in the Genus database with same CATH homology
 2WJ1 A;  3H0L A;  1OBI A;  3H0M A;  4GYS A;  1MT5 A;  4N0I A;  2DC0 A;  3A1I A;  1O9O A;  3QK5 A;  4YJI A;  1M22 A;  3H0R A;  3A2Q A;  5EWQ A;  3KFU E;  1OCL A;  1O9N A;  1OBJ A;  1OCM A;  2G5H A;  4WJ3 A;  3K7F A;  4CP8 A;  3PPM A;  4YJ6 A;  2VYA A;  3AL0 A;  2G5I A;  4HBP A;  1M21 A;  3K84 A;  3LJ6 A;  2DQN A;  3QKV A;  1OBL A;  3QJ9 A;  3A1K A;  3K83 A;  1OCK A;  2WJ2 A;  1O9P A;  4N0H A;  4GYR A;  1OCH A;  2DF4 A;  2WAP A;  2GI3 A;  3LJ7 A;  3PR0 A;  1O9Q A;  2F2A A;  3OJ8 A;  3IP4 A;  4J5P A;  4ISS A;  3A2P A;  4IST A;  4DO3 A;  3QJ8 A;  5AC3 A;  1OBK A; 
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similar chains in the Genus database (?% sequence similarity)
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