3PR0A

Crystal structure of a covalently bound alpha-ketoheterocycle inhibitor (phenhexyl/oxadiazole/pyridine) to a humanized variant of fatty acid amide hydrolase
Total Genus 225
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
225
sequence length
545
structure length
545
Chain Sequence
GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Fatty Acid Amide Hydrolase 1
publication title Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase.
pubmed doi rcsb
source organism Rattus norvegicus
total genus 225
structure length 545
sequence length 545
chains with identical sequence B
ec nomenclature ec 3.5.1.99: Fatty acid amide hydrolase.
pdb deposition date 2010-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01425 Amidase Amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1300.10 Alpha Beta Alpha-Beta Complex Amidase signature (AS) enzymes Amidase signature (AS) domain 3pr0A00
3K84A 4ISSA 1M22A 1OBJA 4CP8A 2WAPA 4ISTA 3PPMA 3A2QA 5EWQA 1O9OA 3KFUE 1O9PA 1OCKA 4GYSA 1OCLA 2WJ1A 3LJ7A 3A2PA 2WJ2A 3A1KA 2VYAA 3H0RA 3PR0A 3K83A 3IP4A 1MT5A 2G5HA 5AC3A 3A1IA 3QK5A 1O9QA 3AL0A 1O9NA 3OJ8A 4N0HA 4HBPA 2G5IA 2F2AA 4J5PA 4YJ6A 4DO3A 1OBKA 2DC0A 1M21A 3QKVA 1OBIA 3LJ6A 4WJ3A 3QJ9A 1OBLA 2GI3A 4YJIA 2DF4A 3H0LA 3H0MA 1OCHA 2DQNA 4GYRA 4N0IA 3K7FA 1OCMA 3QJ8A
chains in the Genus database with same CATH superfamily
3K84A 4ISSA 1M22A 1OBJA 4CP8A 2WAPA 4ISTA 3PPMA 3A2QA 5EWQA 1O9OA 3KFUE 1O9PA 1OCKA 4GYSA 1OCLA 2WJ1A 3LJ7A 3A2PA 2WJ2A 3A1KA 2VYAA 3H0RA 3PR0A 3K83A 3IP4A 1MT5A 2G5HA 5AC3A 3A1IA 3QK5A 1O9QA 3AL0A 1O9NA 3OJ8A 4N0HA 4HBPA 2G5IA 2F2AA 4J5PA 4YJ6A 4DO3A 1OBKA 2DC0A 1M21A 3QKVA 1OBIA 3LJ6A 4WJ3A 3QJ9A 1OBLA 2GI3A 4YJIA 2DF4A 3H0LA 3H0MA 1OCHA 2DQNA 4GYRA 4N0IA 3K7FA 1OCMA 3QJ8A
chains in the Genus database with same CATH topology
3K84A 4ISSA 1M22A 1OBJA 4CP8A 2WAPA 4ISTA 3PPMA 3A2QA 5EWQA 1O9OA 3KFUE 1O9PA 1OCKA 4GYSA 1OCLA 2WJ1A 3LJ7A 3A2PA 2WJ2A 3A1KA 2VYAA 3H0RA 3PR0A 3K83A 3IP4A 1MT5A 2G5HA 5AC3A 3A1IA 3QK5A 1O9QA 3AL0A 1O9NA 3OJ8A 4N0HA 4HBPA 2G5IA 2F2AA 4J5PA 4YJ6A 4DO3A 1OBKA 2DC0A 1M21A 3QKVA 1OBIA 3LJ6A 4WJ3A 3QJ9A 1OBLA 2GI3A 4YJIA 2DF4A 3H0LA 3H0MA 1OCHA 2DQNA 4GYRA 4N0IA 3K7FA 1OCMA 3QJ8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3K84 A;  4ISS A;  1M22 A;  1OBJ A;  4CP8 A;  2WAP A;  4IST A;  3PPM A;  3A2Q A;  5EWQ A;  1O9O A;  3KFU E;  1O9P A;  1OCK A;  4GYS A;  1OCL A;  2WJ1 A;  3LJ7 A;  3A2P A;  2WJ2 A;  3A1K A;  2VYA A;  3H0R A;  3PR0 A;  3K83 A;  3IP4 A;  1MT5 A;  2G5H A;  5AC3 A;  3A1I A;  3QK5 A;  1O9Q A;  3AL0 A;  1O9N A;  3OJ8 A;  4N0H A;  4HBP A;  2G5I A;  2F2A A;  4J5P A;  4YJ6 A;  4DO3 A;  1OBK A;  2DC0 A;  1M21 A;  3QKV A;  1OBI A;  3LJ6 A;  4WJ3 A;  3QJ9 A;  1OBL A;  2GI3 A;  4YJI A;  2DF4 A;  3H0L A;  3H0M A;  1OCH A;  2DQN A;  4GYR A;  4N0I A;  3K7F A;  1OCM A;  3QJ8 A; 
#chains in the Genus database with same CATH topology
 3K84 A;  4ISS A;  1M22 A;  1OBJ A;  4CP8 A;  2WAP A;  4IST A;  3PPM A;  3A2Q A;  5EWQ A;  1O9O A;  3KFU E;  1O9P A;  1OCK A;  4GYS A;  1OCL A;  2WJ1 A;  3LJ7 A;  3A2P A;  2WJ2 A;  3A1K A;  2VYA A;  3H0R A;  3PR0 A;  3K83 A;  3IP4 A;  1MT5 A;  2G5H A;  5AC3 A;  3A1I A;  3QK5 A;  1O9Q A;  3AL0 A;  1O9N A;  3OJ8 A;  4N0H A;  4HBP A;  2G5I A;  2F2A A;  4J5P A;  4YJ6 A;  4DO3 A;  1OBK A;  2DC0 A;  1M21 A;  3QKV A;  1OBI A;  3LJ6 A;  4WJ3 A;  3QJ9 A;  1OBL A;  2GI3 A;  4YJI A;  2DF4 A;  3H0L A;  3H0M A;  1OCH A;  2DQN A;  4GYR A;  4N0I A;  3K7F A;  1OCM A;  3QJ8 A; 
#chains in the Genus database with same CATH homology
 3K84 A;  4ISS A;  1M22 A;  1OBJ A;  4CP8 A;  2WAP A;  4IST A;  3PPM A;  3A2Q A;  5EWQ A;  1O9O A;  3KFU E;  1O9P A;  1OCK A;  4GYS A;  1OCL A;  2WJ1 A;  3LJ7 A;  3A2P A;  2WJ2 A;  3A1K A;  2VYA A;  3H0R A;  3PR0 A;  3K83 A;  3IP4 A;  1MT5 A;  2G5H A;  5AC3 A;  3A1I A;  3QK5 A;  1O9Q A;  3AL0 A;  1O9N A;  3OJ8 A;  4N0H A;  4HBP A;  2G5I A;  2F2A A;  4J5P A;  4YJ6 A;  4DO3 A;  1OBK A;  2DC0 A;  1M21 A;  3QKV A;  1OBI A;  3LJ6 A;  4WJ3 A;  3QJ9 A;  1OBL A;  2GI3 A;  4YJI A;  2DF4 A;  3H0L A;  3H0M A;  1OCH A;  2DQN A;  4GYR A;  4N0I A;  3K7F A;  1OCM A;  3QJ8 A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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