2B5TA

2.1 angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic sr123781 and two s195a thrombin molecules
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
47
structure length
47
Chain Sequence
TSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
pubmed doi rcsb
molecule tags Blood clotting
source organism Homo sapiens
molecule keywords Thrombin
total genus 3
structure length 47
sequence length 47
chains with identical sequence C
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2005-09-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09396 Thrombin_light Thrombin light chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 2b5tA00
2A1DA 2B5TA 1A0HA 1AVGL 2PGQA 2PUXA 3E6PL 2PV9A 3B9FL 3LU9A 1TBRJ 3GISA 3HK6A 1JOUA 1JMOL 1TQ7A 3BEIA 1TB6L 3EDXA 4DY7A 1TBQJ 3HKIA 4RKOA 3BEFA 2ODYA 1Z8JA
chains in the Genus database with same CATH superfamily
2A1DA 2B5TA 1A0HA 1AVGL 2PGQA 2PUXA 3E6PL 2PV9A 3B9FL 3LU9A 1TBRJ 3GISA 3HK6A 1JOUA 1JMOL 1TQ7A 3BEIA 1TB6L 3EDXA 4DY7A 1TBQJ 3HKIA 4RKOA 3BEFA 2ODYA 1Z8JA
chains in the Genus database with same CATH topology
2A1DA 2B5TA 1A0HA 1AVGL 2PGQA 2PUXA 3E6PL 2PV9A 3B9FL 3LU9A 1TBRJ 3GISA 3HK6A 1JOUA 1JMOL 1TQ7A 3BEIA 1TB6L 3EDXA 4DY7A 1TBQJ 3HKIA 4RKOA 3BEFA 2ODYA 1Z8JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2A1D A;  2B5T A;  1A0H A;  1AVG L;  2PGQ A;  2PUX A;  3E6P L;  2PV9 A;  3B9F L;  3LU9 A;  1TBR J;  3GIS A;  3HK6 A;  1JOU A;  1JMO L;  1TQ7 A;  3BEI A;  1TB6 L;  3EDX A;  4DY7 A;  1TBQ J;  3HKI A;  4RKO A;  3BEF A;  2ODY A;  1Z8J A; 
#chains in the Genus database with same CATH topology
 2A1D A;  2B5T A;  1A0H A;  1AVG L;  2PGQ A;  2PUX A;  3E6P L;  2PV9 A;  3B9F L;  3LU9 A;  1TBR J;  3GIS A;  3HK6 A;  1JOU A;  1JMO L;  1TQ7 A;  3BEI A;  1TB6 L;  3EDX A;  4DY7 A;  1TBQ J;  3HKI A;  4RKO A;  3BEF A;  2ODY A;  1Z8J A; 
#chains in the Genus database with same CATH homology
 2A1D A;  2B5T A;  1A0H A;  1AVG L;  2PGQ A;  2PUX A;  3E6P L;  2PV9 A;  3B9F L;  3LU9 A;  1TBR J;  3GIS A;  3HK6 A;  1JOU A;  1JMO L;  1TQ7 A;  3BEI A;  1TB6 L;  3EDX A;  4DY7 A;  1TBQ J;  3HKI A;  4RKO A;  3BEF A;  2ODY A;  1Z8J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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