2HAPC

Structure of a hap1-18/dna complex reveals that protein/dna interactions can have direct allosteric effects on transcriptional activation
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
76
structure length
76
Chain Sequence
RKRNRIPLRCTICRKRKVKCDKLRPHCQQCTKTGVAHLCHYMEQTWAEEAEKELLKDNELKKLRERVKSLEKTLSK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation.
pubmed doi rcsb
molecule tags Gene regulation/dna
source organism Saccharomyces cerevisiae
molecule keywords DNA (5'-D(*AP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*T
total genus 19
structure length 76
sequence length 76
chains with identical sequence D
ec nomenclature
pdb deposition date 1998-09-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00172 Zn_clus Fungal Zn(2)-Cys(6) binuclear cluster domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.240.10 Few Secondary Structures Irregular CD2-Gal4 Zn(2)-C6 fungal-type DNA-binding domain 2hapC01
1PYIA 2EREA 1AJYA 1PYCA 1AW6A 3COQA 1F5EP 1F4SP 2ERGA 2ALCA 1QP9A 2ER8A 3ALCA 1ZMEC 2HAPC 1D66A 1HWTC
chains in the Genus database with same CATH superfamily
1PYIA 2EREA 1AJYA 1PYCA 1AW6A 3COQA 1F5EP 1F4SP 2ERGA 2ALCA 1QP9A 2ER8A 3ALCA 1ZMEC 2HAPC 1D66A 1HWTC
chains in the Genus database with same CATH topology
1PYIA 2EREA 1AJYA 1PYCA 1AW6A 3COQA 1F5EP 1F4SP 2ERGA 2ALCA 1QP9A 2ER8A 3ALCA 1ZMEC 2HAPC 1D66A 1HWTC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PYI A;  2ERE A;  1AJY A;  1PYC A;  1AW6 A;  3COQ A;  1F5E P;  1F4S P;  2ERG A;  2ALC A;  1QP9 A;  2ER8 A;  3ALC A;  1ZME C;  2HAP C;  1D66 A;  1HWT C; 
#chains in the Genus database with same CATH topology
 1PYI A;  2ERE A;  1AJY A;  1PYC A;  1AW6 A;  3COQ A;  1F5E P;  1F4S P;  2ERG A;  2ALC A;  1QP9 A;  2ER8 A;  3ALC A;  1ZME C;  2HAP C;  1D66 A;  1HWT C; 
#chains in the Genus database with same CATH homology
 1PYI A;  2ERE A;  1AJY A;  1PYC A;  1AW6 A;  3COQ A;  1F5E P;  1F4S P;  2ERG A;  2ALC A;  1QP9 A;  2ER8 A;  3ALC A;  1ZME C;  2HAP C;  1D66 A;  1HWT C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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