2PGQA

Human thrombin mutant c191a-c220a in complex with the inhibitor ppack
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
43
structure length
43
Chain Sequence
EYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Prothrombin
total genus 1
structure length 43
sequence length 43
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2007-04-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 2pgqA00
2PUXA 3BEFA 4DY7A 1JOUA 3GISA 2B5TA 3B9FL 3BEIA 3HK6A 2PV9A 3HKIA 3E6PL 4RKOA 3LU9A 1AVGL 2ODYA 3EDXA 1Z8JA 1TBQJ 1A0HA 1TQ7A 1JMOL 1TBRJ 2A1DA 1TB6L 2PGQA
chains in the Genus database with same CATH superfamily
2PUXA 3BEFA 4DY7A 1JOUA 3GISA 2B5TA 3B9FL 3BEIA 3HK6A 2PV9A 3HKIA 3E6PL 4RKOA 3LU9A 1AVGL 2ODYA 3EDXA 1Z8JA 1TBQJ 1A0HA 1TQ7A 1JMOL 1TBRJ 2A1DA 1TB6L 2PGQA
chains in the Genus database with same CATH topology
2PUXA 3BEFA 4DY7A 1JOUA 3GISA 2B5TA 3B9FL 3BEIA 3HK6A 2PV9A 3HKIA 3E6PL 4RKOA 3LU9A 1AVGL 2ODYA 3EDXA 1Z8JA 1TBQJ 1A0HA 1TQ7A 1JMOL 1TBRJ 2A1DA 1TB6L 2PGQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PUX A;  3BEF A;  4DY7 A;  1JOU A;  3GIS A;  2B5T A;  3B9F L;  3BEI A;  3HK6 A;  2PV9 A;  3HKI A;  3E6P L;  4RKO A;  3LU9 A;  1AVG L;  2ODY A;  3EDX A;  1Z8J A;  1TBQ J;  1A0H A;  1TQ7 A;  1JMO L;  1TBR J;  2A1D A;  1TB6 L;  2PGQ A; 
#chains in the Genus database with same CATH topology
 2PUX A;  3BEF A;  4DY7 A;  1JOU A;  3GIS A;  2B5T A;  3B9F L;  3BEI A;  3HK6 A;  2PV9 A;  3HKI A;  3E6P L;  4RKO A;  3LU9 A;  1AVG L;  2ODY A;  3EDX A;  1Z8J A;  1TBQ J;  1A0H A;  1TQ7 A;  1JMO L;  1TBR J;  2A1D A;  1TB6 L;  2PGQ A; 
#chains in the Genus database with same CATH homology
 2PUX A;  3BEF A;  4DY7 A;  1JOU A;  3GIS A;  2B5T A;  3B9F L;  3BEI A;  3HK6 A;  2PV9 A;  3HKI A;  3E6P L;  4RKO A;  3LU9 A;  1AVG L;  2ODY A;  3EDX A;  1Z8J A;  1TBQ J;  1A0H A;  1TQ7 A;  1JMO L;  1TBR J;  2A1D A;  1TB6 L;  2PGQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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