3BEIA

Crystal structure of the slow form of thrombin in a self_inhibited conformation
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
41
structure length
41
Chain Sequence
YQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural identification of the pathway of long-range communication in an allosteric enzyme.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Prothrombin
total genus 3
structure length 41
sequence length 41
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2007-11-19
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 3beiA00
1AVGL 1TB6L 3E6PL 1TBQJ 3LU9A 2A1DA 1JMOL 2ODYA 2B5TA 1TBRJ 3BEIA 4RKOA 3GISA 1A0HA 3HK6A 3BEFA 3B9FL 4DY7A 1TQ7A 3EDXA 2PUXA 3HKIA 1JOUA 2PV9A 2PGQA 1Z8JA
chains in the Genus database with same CATH superfamily
1AVGL 1TB6L 3E6PL 1TBQJ 3LU9A 2A1DA 1JMOL 2ODYA 2B5TA 1TBRJ 3BEIA 4RKOA 3GISA 1A0HA 3HK6A 3BEFA 3B9FL 4DY7A 1TQ7A 3EDXA 2PUXA 3HKIA 1JOUA 2PV9A 2PGQA 1Z8JA
chains in the Genus database with same CATH topology
1AVGL 1TB6L 3E6PL 1TBQJ 3LU9A 2A1DA 1JMOL 2ODYA 2B5TA 1TBRJ 3BEIA 4RKOA 3GISA 1A0HA 3HK6A 3BEFA 3B9FL 4DY7A 1TQ7A 3EDXA 2PUXA 3HKIA 1JOUA 2PV9A 2PGQA 1Z8JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AVG L;  1TB6 L;  3E6P L;  1TBQ J;  3LU9 A;  2A1D A;  1JMO L;  2ODY A;  2B5T A;  1TBR J;  3BEI A;  4RKO A;  3GIS A;  1A0H A;  3HK6 A;  3BEF A;  3B9F L;  4DY7 A;  1TQ7 A;  3EDX A;  2PUX A;  3HKI A;  1JOU A;  2PV9 A;  2PGQ A;  1Z8J A; 
#chains in the Genus database with same CATH topology
 1AVG L;  1TB6 L;  3E6P L;  1TBQ J;  3LU9 A;  2A1D A;  1JMO L;  2ODY A;  2B5T A;  1TBR J;  3BEI A;  4RKO A;  3GIS A;  1A0H A;  3HK6 A;  3BEF A;  3B9F L;  4DY7 A;  1TQ7 A;  3EDX A;  2PUX A;  3HKI A;  1JOU A;  2PV9 A;  2PGQ A;  1Z8J A; 
#chains in the Genus database with same CATH homology
 1AVG L;  1TB6 L;  3E6P L;  1TBQ J;  3LU9 A;  2A1D A;  1JMO L;  2ODY A;  2B5T A;  1TBR J;  3BEI A;  4RKO A;  3GIS A;  1A0H A;  3HK6 A;  3BEF A;  3B9F L;  4DY7 A;  1TQ7 A;  3EDX A;  2PUX A;  3HKI A;  1JOU A;  2PV9 A;  2PGQ A;  1Z8J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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