3GISA

Crystal structure of na-free thrombin in complex with thrombomodulin
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
46
structure length
46
Chain Sequence
SEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular basis of thrombomodulin activation of slow thrombin
pubmed doi rcsb
molecule tags Blood clotting
source organism Homo sapiens
molecule keywords Prothrombin
total genus 3
structure length 46
sequence length 46
chains with identical sequence C, E
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2009-03-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09396 Thrombin_light Thrombin light chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 3gisA00
3HKIA 3HK6A 1AVGL 3EDXA 3BEFA 4RKOA 1A0HA 3E6PL 2B5TA 1TBRJ 2PGQA 1TBQJ 1JOUA 2A1DA 3BEIA 4DY7A 3GISA 1TQ7A 3LU9A 2PUXA 1Z8JA 3B9FL 1JMOL 2ODYA 1TB6L 2PV9A
chains in the Genus database with same CATH superfamily
3HKIA 3HK6A 1AVGL 3EDXA 3BEFA 4RKOA 1A0HA 3E6PL 2B5TA 1TBRJ 2PGQA 1TBQJ 1JOUA 2A1DA 3BEIA 4DY7A 3GISA 1TQ7A 3LU9A 2PUXA 1Z8JA 3B9FL 1JMOL 2ODYA 1TB6L 2PV9A
chains in the Genus database with same CATH topology
3HKIA 3HK6A 1AVGL 3EDXA 3BEFA 4RKOA 1A0HA 3E6PL 2B5TA 1TBRJ 2PGQA 1TBQJ 1JOUA 2A1DA 3BEIA 4DY7A 3GISA 1TQ7A 3LU9A 2PUXA 1Z8JA 3B9FL 1JMOL 2ODYA 1TB6L 2PV9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HKI A;  3HK6 A;  1AVG L;  3EDX A;  3BEF A;  4RKO A;  1A0H A;  3E6P L;  2B5T A;  1TBR J;  2PGQ A;  1TBQ J;  1JOU A;  2A1D A;  3BEI A;  4DY7 A;  3GIS A;  1TQ7 A;  3LU9 A;  2PUX A;  1Z8J A;  3B9F L;  1JMO L;  2ODY A;  1TB6 L;  2PV9 A; 
#chains in the Genus database with same CATH topology
 3HKI A;  3HK6 A;  1AVG L;  3EDX A;  3BEF A;  4RKO A;  1A0H A;  3E6P L;  2B5T A;  1TBR J;  2PGQ A;  1TBQ J;  1JOU A;  2A1D A;  3BEI A;  4DY7 A;  3GIS A;  1TQ7 A;  3LU9 A;  2PUX A;  1Z8J A;  3B9F L;  1JMO L;  2ODY A;  1TB6 L;  2PV9 A; 
#chains in the Genus database with same CATH homology
 3HKI A;  3HK6 A;  1AVG L;  3EDX A;  3BEF A;  4RKO A;  1A0H A;  3E6P L;  2B5T A;  1TBR J;  2PGQ A;  1TBQ J;  1JOU A;  2A1D A;  3BEI A;  4DY7 A;  3GIS A;  1TQ7 A;  3LU9 A;  2PUX A;  1Z8J A;  3B9F L;  1JMO L;  2ODY A;  1TB6 L;  2PV9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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