3HK6A

Crystal structure of murine thrombin mutant w215a/e217a (two molecules in the asymmetric unit)
Total Genus 3
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
FHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSYIDG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A.
pubmed doi rcsb
molecule tags Hydrolase
source organism Mus musculus
molecule keywords Thrombin light chain
total genus 3
structure length 43
sequence length 43
chains with identical sequence C
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2009-05-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 3hk6A00
2PV9A 1TQ7A 2A1DA 1JOUA 3BEIA 3HK6A 2PUXA 1Z8JA 3LU9A 2B5TA 2ODYA 3E6PL 1JMOL 3EDXA 1AVGL 1TBQJ 2PGQA 4RKOA 3HKIA 3B9FL 1TBRJ 1TB6L 3GISA 4DY7A 1A0HA 3BEFA
chains in the Genus database with same CATH superfamily
2PV9A 1TQ7A 2A1DA 1JOUA 3BEIA 3HK6A 2PUXA 1Z8JA 3LU9A 2B5TA 2ODYA 3E6PL 1JMOL 3EDXA 1AVGL 1TBQJ 2PGQA 4RKOA 3HKIA 3B9FL 1TBRJ 1TB6L 3GISA 4DY7A 1A0HA 3BEFA
chains in the Genus database with same CATH topology
2PV9A 1TQ7A 2A1DA 1JOUA 3BEIA 3HK6A 2PUXA 1Z8JA 3LU9A 2B5TA 2ODYA 3E6PL 1JMOL 3EDXA 1AVGL 1TBQJ 2PGQA 4RKOA 3HKIA 3B9FL 1TBRJ 1TB6L 3GISA 4DY7A 1A0HA 3BEFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PV9 A;  1TQ7 A;  2A1D A;  1JOU A;  3BEI A;  3HK6 A;  2PUX A;  1Z8J A;  3LU9 A;  2B5T A;  2ODY A;  3E6P L;  1JMO L;  3EDX A;  1AVG L;  1TBQ J;  2PGQ A;  4RKO A;  3HKI A;  3B9F L;  1TBR J;  1TB6 L;  3GIS A;  4DY7 A;  1A0H A;  3BEF A; 
#chains in the Genus database with same CATH topology
 2PV9 A;  1TQ7 A;  2A1D A;  1JOU A;  3BEI A;  3HK6 A;  2PUX A;  1Z8J A;  3LU9 A;  2B5T A;  2ODY A;  3E6P L;  1JMO L;  3EDX A;  1AVG L;  1TBQ J;  2PGQ A;  4RKO A;  3HKI A;  3B9F L;  1TBR J;  1TB6 L;  3GIS A;  4DY7 A;  1A0H A;  3BEF A; 
#chains in the Genus database with same CATH homology
 2PV9 A;  1TQ7 A;  2A1D A;  1JOU A;  3BEI A;  3HK6 A;  2PUX A;  1Z8J A;  3LU9 A;  2B5T A;  2ODY A;  3E6P L;  1JMO L;  3EDX A;  1AVG L;  1TBQ J;  2PGQ A;  4RKO A;  3HKI A;  3B9F L;  1TBR J;  1TB6 L;  3GIS A;  4DY7 A;  1A0H A;  3BEF A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...