3K7FA

Crystal structure analysis of a phenhexyl/oxazole/carboxypyridine alpha-ketoheterocycle inhibitor bound to a humanized variant of fatty acid amide hydrolase'
Total Genus 223
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
223
sequence length
543
structure length
543
Chain Sequence
TGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords Fatty-acid amide hydrolase 1
total genus 223
structure length 543
sequence length 543
chains with identical sequence B
ec nomenclature ec 3.5.1.99: Fatty acid amide hydrolase.
pdb deposition date 2009-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01425 Amidase Amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1300.10 Alpha Beta Alpha-Beta Complex Amidase signature (AS) enzymes Amidase signature (AS) domain 3k7fA00
1O9NA 3A1KA 3IP4A 2DF4A 4N0HA 1M22A 2DC0A 2GI3A 4ISTA 5AC3A 2F2AA 1OCLA 3QJ8A 4WJ3A 3LJ6A 1OBIA 3QJ9A 3PPMA 3H0MA 3K84A 2DQNA 1O9OA 1OBKA 2WJ1A 3A2QA 4GYRA 1OBJA 2WJ2A 3A1IA 4DO3A 3QK5A 3K7FA 4GYSA 3LJ7A 3H0RA 1OCKA 3KFUE 3AL0A 3K83A 3PR0A 4N0IA 1OBLA 1O9QA 2G5HA 1M21A 4YJ6A 1O9PA 2WAPA 3A2PA 5EWQA 2G5IA 4ISSA 1OCMA 2VYAA 4CP8A 3H0LA 4J5PA 4HBPA 3QKVA 3OJ8A 4YJIA 1OCHA 1MT5A
chains in the Genus database with same CATH superfamily
1O9NA 3A1KA 3IP4A 2DF4A 4N0HA 1M22A 2DC0A 2GI3A 4ISTA 5AC3A 2F2AA 1OCLA 3QJ8A 4WJ3A 3LJ6A 1OBIA 3QJ9A 3PPMA 3H0MA 3K84A 2DQNA 1O9OA 1OBKA 2WJ1A 3A2QA 4GYRA 1OBJA 2WJ2A 3A1IA 4DO3A 3QK5A 3K7FA 4GYSA 3LJ7A 3H0RA 1OCKA 3KFUE 3AL0A 3K83A 3PR0A 4N0IA 1OBLA 1O9QA 2G5HA 1M21A 4YJ6A 1O9PA 2WAPA 3A2PA 5EWQA 2G5IA 4ISSA 1OCMA 2VYAA 4CP8A 3H0LA 4J5PA 4HBPA 3QKVA 3OJ8A 4YJIA 1OCHA 1MT5A
chains in the Genus database with same CATH topology
1O9NA 3A1KA 3IP4A 2DF4A 4N0HA 1M22A 2DC0A 2GI3A 4ISTA 5AC3A 2F2AA 1OCLA 3QJ8A 4WJ3A 3LJ6A 1OBIA 3QJ9A 3PPMA 3H0MA 3K84A 2DQNA 1O9OA 1OBKA 2WJ1A 3A2QA 4GYRA 1OBJA 2WJ2A 3A1IA 4DO3A 3QK5A 3K7FA 4GYSA 3LJ7A 3H0RA 1OCKA 3KFUE 3AL0A 3K83A 3PR0A 4N0IA 1OBLA 1O9QA 2G5HA 1M21A 4YJ6A 1O9PA 2WAPA 3A2PA 5EWQA 2G5IA 4ISSA 1OCMA 2VYAA 4CP8A 3H0LA 4J5PA 4HBPA 3QKVA 3OJ8A 4YJIA 1OCHA 1MT5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O9N A;  3A1K A;  3IP4 A;  2DF4 A;  4N0H A;  1M22 A;  2DC0 A;  2GI3 A;  4IST A;  5AC3 A;  2F2A A;  1OCL A;  3QJ8 A;  4WJ3 A;  3LJ6 A;  1OBI A;  3QJ9 A;  3PPM A;  3H0M A;  3K84 A;  2DQN A;  1O9O A;  1OBK A;  2WJ1 A;  3A2Q A;  4GYR A;  1OBJ A;  2WJ2 A;  3A1I A;  4DO3 A;  3QK5 A;  3K7F A;  4GYS A;  3LJ7 A;  3H0R A;  1OCK A;  3KFU E;  3AL0 A;  3K83 A;  3PR0 A;  4N0I A;  1OBL A;  1O9Q A;  2G5H A;  1M21 A;  4YJ6 A;  1O9P A;  2WAP A;  3A2P A;  5EWQ A;  2G5I A;  4ISS A;  1OCM A;  2VYA A;  4CP8 A;  3H0L A;  4J5P A;  4HBP A;  3QKV A;  3OJ8 A;  4YJI A;  1OCH A;  1MT5 A; 
#chains in the Genus database with same CATH topology
 1O9N A;  3A1K A;  3IP4 A;  2DF4 A;  4N0H A;  1M22 A;  2DC0 A;  2GI3 A;  4IST A;  5AC3 A;  2F2A A;  1OCL A;  3QJ8 A;  4WJ3 A;  3LJ6 A;  1OBI A;  3QJ9 A;  3PPM A;  3H0M A;  3K84 A;  2DQN A;  1O9O A;  1OBK A;  2WJ1 A;  3A2Q A;  4GYR A;  1OBJ A;  2WJ2 A;  3A1I A;  4DO3 A;  3QK5 A;  3K7F A;  4GYS A;  3LJ7 A;  3H0R A;  1OCK A;  3KFU E;  3AL0 A;  3K83 A;  3PR0 A;  4N0I A;  1OBL A;  1O9Q A;  2G5H A;  1M21 A;  4YJ6 A;  1O9P A;  2WAP A;  3A2P A;  5EWQ A;  2G5I A;  4ISS A;  1OCM A;  2VYA A;  4CP8 A;  3H0L A;  4J5P A;  4HBP A;  3QKV A;  3OJ8 A;  4YJI A;  1OCH A;  1MT5 A; 
#chains in the Genus database with same CATH homology
 1O9N A;  3A1K A;  3IP4 A;  2DF4 A;  4N0H A;  1M22 A;  2DC0 A;  2GI3 A;  4IST A;  5AC3 A;  2F2A A;  1OCL A;  3QJ8 A;  4WJ3 A;  3LJ6 A;  1OBI A;  3QJ9 A;  3PPM A;  3H0M A;  3K84 A;  2DQN A;  1O9O A;  1OBK A;  2WJ1 A;  3A2Q A;  4GYR A;  1OBJ A;  2WJ2 A;  3A1I A;  4DO3 A;  3QK5 A;  3K7F A;  4GYS A;  3LJ7 A;  3H0R A;  1OCK A;  3KFU E;  3AL0 A;  3K83 A;  3PR0 A;  4N0I A;  1OBL A;  1O9Q A;  2G5H A;  1M21 A;  4YJ6 A;  1O9P A;  2WAP A;  3A2P A;  5EWQ A;  2G5I A;  4ISS A;  1OCM A;  2VYA A;  4CP8 A;  3H0L A;  4J5P A;  4HBP A;  3QKV A;  3OJ8 A;  4YJI A;  1OCH A;  1MT5 A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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