3K7FA

Crystal structure analysis of a phenhexyl/oxazole/carboxypyridine alpha-ketoheterocycle inhibitor bound to a humanized variant of fatty acid amide hydrolase'
Total Genus 223
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
223
sequence length
543
structure length
543
Chain Sequence
TGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
source organism Rattus norvegicus
publication title X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.
pubmed doi rcsb
molecule keywords Fatty-acid amide hydrolase 1
total genus 223
structure length 543
sequence length 543
chains with identical sequence B
ec nomenclature ec 3.5.1.99: Fatty acid amide hydrolase.
pdb deposition date 2009-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01425 Amidase Amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1300.10 Alpha Beta Alpha-Beta Complex Amidase signature (AS) enzymes Amidase signature (AS) domain 3k7fA00
4HBPA 4N0IA 3A2PA 2WAPA 3K84A 1O9OA 2DC0A 3LJ6A 1OCMA 1M21A 3PR0A 1OCKA 2DQNA 1OBKA 3QJ9A 3QKVA 4YJ6A 4J5PA 2DF4A 4ISSA 2G5HA 1O9PA 3LJ7A 5AC3A 3OJ8A 2WJ2A 3H0LA 3QK5A 1OCHA 4GYRA 4N0HA 3KFUE 1OCLA 1O9QA 3IP4A 3H0MA 3H0RA 5EWQA 4CP8A 2VYAA 3QJ8A 2WJ1A 3A1IA 4GYSA 2GI3A 1OBIA 3K83A 1OBLA 3AL0A 1O9NA 2F2AA 4ISTA 1M22A 3A1KA 4WJ3A 3K7FA 3A2QA 3PPMA 4YJIA 2G5IA 4DO3A 1MT5A 1OBJA
chains in the Genus database with same CATH superfamily
4HBPA 4N0IA 3A2PA 2WAPA 3K84A 1O9OA 2DC0A 3LJ6A 1OCMA 1M21A 3PR0A 1OCKA 2DQNA 1OBKA 3QJ9A 3QKVA 4YJ6A 4J5PA 2DF4A 4ISSA 2G5HA 1O9PA 3LJ7A 5AC3A 3OJ8A 2WJ2A 3H0LA 3QK5A 1OCHA 4GYRA 4N0HA 3KFUE 1OCLA 1O9QA 3IP4A 3H0MA 3H0RA 5EWQA 4CP8A 2VYAA 3QJ8A 2WJ1A 3A1IA 4GYSA 2GI3A 1OBIA 3K83A 1OBLA 3AL0A 1O9NA 2F2AA 4ISTA 1M22A 3A1KA 4WJ3A 3K7FA 3A2QA 3PPMA 4YJIA 2G5IA 4DO3A 1MT5A 1OBJA
chains in the Genus database with same CATH topology
4HBPA 4N0IA 3A2PA 2WAPA 3K84A 1O9OA 2DC0A 3LJ6A 1OCMA 1M21A 3PR0A 1OCKA 2DQNA 1OBKA 3QJ9A 3QKVA 4YJ6A 4J5PA 2DF4A 4ISSA 2G5HA 1O9PA 3LJ7A 5AC3A 3OJ8A 2WJ2A 3H0LA 3QK5A 1OCHA 4GYRA 4N0HA 3KFUE 1OCLA 1O9QA 3IP4A 3H0MA 3H0RA 5EWQA 4CP8A 2VYAA 3QJ8A 2WJ1A 3A1IA 4GYSA 2GI3A 1OBIA 3K83A 1OBLA 3AL0A 1O9NA 2F2AA 4ISTA 1M22A 3A1KA 4WJ3A 3K7FA 3A2QA 3PPMA 4YJIA 2G5IA 4DO3A 1MT5A 1OBJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HBP A;  4N0I A;  3A2P A;  2WAP A;  3K84 A;  1O9O A;  2DC0 A;  3LJ6 A;  1OCM A;  1M21 A;  3PR0 A;  1OCK A;  2DQN A;  1OBK A;  3QJ9 A;  3QKV A;  4YJ6 A;  4J5P A;  2DF4 A;  4ISS A;  2G5H A;  1O9P A;  3LJ7 A;  5AC3 A;  3OJ8 A;  2WJ2 A;  3H0L A;  3QK5 A;  1OCH A;  4GYR A;  4N0H A;  3KFU E;  1OCL A;  1O9Q A;  3IP4 A;  3H0M A;  3H0R A;  5EWQ A;  4CP8 A;  2VYA A;  3QJ8 A;  2WJ1 A;  3A1I A;  4GYS A;  2GI3 A;  1OBI A;  3K83 A;  1OBL A;  3AL0 A;  1O9N A;  2F2A A;  4IST A;  1M22 A;  3A1K A;  4WJ3 A;  3K7F A;  3A2Q A;  3PPM A;  4YJI A;  2G5I A;  4DO3 A;  1MT5 A;  1OBJ A; 
#chains in the Genus database with same CATH topology
 4HBP A;  4N0I A;  3A2P A;  2WAP A;  3K84 A;  1O9O A;  2DC0 A;  3LJ6 A;  1OCM A;  1M21 A;  3PR0 A;  1OCK A;  2DQN A;  1OBK A;  3QJ9 A;  3QKV A;  4YJ6 A;  4J5P A;  2DF4 A;  4ISS A;  2G5H A;  1O9P A;  3LJ7 A;  5AC3 A;  3OJ8 A;  2WJ2 A;  3H0L A;  3QK5 A;  1OCH A;  4GYR A;  4N0H A;  3KFU E;  1OCL A;  1O9Q A;  3IP4 A;  3H0M A;  3H0R A;  5EWQ A;  4CP8 A;  2VYA A;  3QJ8 A;  2WJ1 A;  3A1I A;  4GYS A;  2GI3 A;  1OBI A;  3K83 A;  1OBL A;  3AL0 A;  1O9N A;  2F2A A;  4IST A;  1M22 A;  3A1K A;  4WJ3 A;  3K7F A;  3A2Q A;  3PPM A;  4YJI A;  2G5I A;  4DO3 A;  1MT5 A;  1OBJ A; 
#chains in the Genus database with same CATH homology
 4HBP A;  4N0I A;  3A2P A;  2WAP A;  3K84 A;  1O9O A;  2DC0 A;  3LJ6 A;  1OCM A;  1M21 A;  3PR0 A;  1OCK A;  2DQN A;  1OBK A;  3QJ9 A;  3QKV A;  4YJ6 A;  4J5P A;  2DF4 A;  4ISS A;  2G5H A;  1O9P A;  3LJ7 A;  5AC3 A;  3OJ8 A;  2WJ2 A;  3H0L A;  3QK5 A;  1OCH A;  4GYR A;  4N0H A;  3KFU E;  1OCL A;  1O9Q A;  3IP4 A;  3H0M A;  3H0R A;  5EWQ A;  4CP8 A;  2VYA A;  3QJ8 A;  2WJ1 A;  3A1I A;  4GYS A;  2GI3 A;  1OBI A;  3K83 A;  1OBL A;  3AL0 A;  1O9N A;  2F2A A;  4IST A;  1M22 A;  3A1K A;  4WJ3 A;  3K7F A;  3A2Q A;  3PPM A;  4YJI A;  2G5I A;  4DO3 A;  1MT5 A;  1OBJ A; 
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similar chains in the Genus database (?% sequence similarity)
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